Ethyl isocyanoacetate
- Product Name
- Ethyl isocyanoacetate
- CAS No.
- 2999-46-4
- Chemical Name
- Ethyl isocyanoacetate
- Synonyms
- Ethyl 2-isocyanoacetate;Isocyanoacetate;2-Oxo-2-ethoxyethyl isocyanide;HANSA ISN-0528;BIO-FARMA BF001872;ethyl isocyanzacetate;ETHYL ISOCYANOACETATE;Ethylisocyanatoactate;EthylIsocyanoacetate>Ethylisocyanoacetate,98%
- CBNumber
- CB7209404
- Molecular Formula
- C5H7NO2
- Formula Weight
- 113.11
- MOL File
- 2999-46-4.mol
Ethyl isocyanoacetate Property
- Boiling point:
- 194-196 °C (lit.)
- Density
- 1.035 g/mL at 25 °C (lit.)
- vapor pressure
- 61.7Pa at 25℃
- refractive index
- n20/D 1.418(lit.)
- Flash point:
- 184 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform, Methanol (Slightly)
- form
- Liquid
- color
- Clear amber to dark brown
- Water Solubility
- Miscible with organic solvents. Slightly miscible with water.
- Sensitive
- Moisture & Light Sensitive
- BRN
- 3588613
- Exposure limits
- NIOSH: IDLH 25 mg/m3
- LogP
- 0.91 at 25℃
- CAS DataBase Reference
- 2999-46-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/22-20/21/22
- Safety Statements
- 36/37/39-26-36/37-24/25
- RIDADR
- UN 2810 6.1/PG 3
- WGK Germany
- 3
- F
- 8-9-21
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29299090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- 226319
- Product name
- Ethyl isocyanoacetate
- Purity
- 95%
- Packaging
- 5g
- Price
- $125
- Updated
- 2024/03/01
- Product number
- 226319
- Product name
- Ethyl isocyanoacetate
- Purity
- 95%
- Packaging
- 25g
- Price
- $272
- Updated
- 2024/03/01
- Product number
- I0562
- Product name
- Ethyl Isocyanoacetate
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $86
- Updated
- 2024/03/01
- Product number
- I0562
- Product name
- Ethyl Isocyanoacetate
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $296
- Updated
- 2024/03/01
- Product number
- L15379
- Product name
- Ethyl isocyanoacetate, 98%
- Packaging
- 1g
- Price
- $36.1
- Updated
- 2024/03/01
Ethyl isocyanoacetate Chemical Properties,Usage,Production
Chemical Properties
Light yellow to brom liquid. Slightly soluble in water and lye, miscible in ethanol and ether.
Uses
Ethyl Isocyanoacetate, is a cyclization synthon used to prepare pyrroles, oxazolines, benzodiazepines, oxazoles and imidazoles. Ethyl isocyanoacetate can be used to prepare pyrroles,1,2 oxazolines, benzodiazepines, oxazoles and imidazoles.
Uses
Ethyl isocyanoacetate is used in the syntheses of 7-aza-tetrahydroindoles, oxazolines, benzodiazepines, imidazoles and oxazoles. For example, it is involved in the synthesis of 1H-indole-2-carboxylate by condensing with 2-bromo benzenealdehyde using CuI as a catalyst. It is a precursor used in the preparation of ethyl thiazole-4-carboxylate upon reaction with O-ethyl thioformate.
Preparation
synthesis of ethyl isocyanoacetate
A solution containing N-formyl glycine ethyl ester (1, 1.31 g, 10 mmol), DIPEA (2.62 g, 20 mmol) and DMAP (0.45 g, 3 mmol) in dry DCM (10 mL) was loaded in a sample loop and combined with a second stream containing triphosgene (2, 0.98 g, 3.3 mmol) also dissolved in dry DCM (10 mL) at individual channel flow rates of 0.5 mL/min. The combined stream was directed into two linked 10 mL FEP reactor vessels to achieve a 20 minutes residence time at ambient temperature. The output was collect and the solvent was carefully evaporated to 80% of its total volume. The crude material was filtered through silica (5 g) and washed with DCM (2 × 10 mL) to obtain the salt-free product. The desired product 3 was obtained as dark yellow oil after evaporation of the organic phase (1.03 g, 91 % isolated yield, >97% purity by 1H NMR).
General Description
Material may darken upon storage
Ethyl isocyanoacetate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl isocyanoacetate Suppliers
- Tel
- 0311-15028179902 15028179902
- Fax
- 18503279000
- bella@hbmojin.com
- Country
- China
- ProdList
- 111
- Advantage
- 58
- Tel
- 18606289633 15862625988
- Fax
- 0512-58813106
- sales@clentchem.com
- Country
- China
- ProdList
- 172
- Advantage
- 60
- Tel
- 15021941186
- 3572772243@qq.com
- Country
- China
- ProdList
- 191
- Advantage
- 58
- Tel
- 021-61259108 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 010-88425576
- Fax
- (+86)-10-88425546
- sales@dhltchem.com
- Country
- China
- ProdList
- 793
- Advantage
- 59
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44688
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 15601563028
- Fax
- 4006648400-2
- Country
- China
- ProdList
- 29
- Advantage
- 60
View Lastest Price from Ethyl isocyanoacetate manufacturers
- Product
- Ethyl isocyanoacetate 2999-46-4
- Price
- US $100.00/drum
- Min. Order
- 1drum
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2023-08-30
- Product
- Ethyl isocyanoacetate 2999-46-4
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2021-10-09
- Product
- Ethyl isocyanoacetate 2999-46-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10