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Ethyl isocyanoacetate

Product Name
Ethyl isocyanoacetate
CAS No.
2999-46-4
Chemical Name
Ethyl isocyanoacetate
Synonyms
HANSA ISN-0528;Isocyanoacetate;BIO-FARMA BF001872;ethyl isocyanzacetate;ETHYL ISOCYANOACETATE;Ethyl 2-isocyanoacetate;EthylIsocyanoacetate>Ethylisocyanoacetate,98%;ethyl forMylaMinoacetate;Ethyl isocyanoacetate,97%
CBNumber
CB7209404
Molecular Formula
C5H7NO2
Formula Weight
113.11
MOL File
2999-46-4.mol
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Ethyl isocyanoacetate Property

Boiling point:
194-196 °C (lit.)
Density 
1.035 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.418(lit.)
Flash point:
184 °F
storage temp. 
2-8°C
form 
Liquid
color 
Clear amber to dark brown
Water Solubility 
Miscible with organic solvents. Slightly miscible with water.
Sensitive 
Moisture & Light Sensitive
BRN 
3588613
CAS DataBase Reference
2999-46-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/22-20/21/22
Safety Statements 
36/37/39-26-36/37-24/25
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
8-9-21
HazardClass 
6.1
PackingGroup 
III
HS Code 
29299090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P405Store locked up.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
226319
Product name
Ethyl isocyanoacetate
Purity
95%
Packaging
5g
Price
$107
Updated
2021/12/16
Sigma-Aldrich
Product number
226319
Product name
Ethyl isocyanoacetate
Purity
95%
Packaging
25g
Price
$279
Updated
2021/12/16
TCI Chemical
Product number
I0562
Product name
Ethyl Isocyanoacetate
Purity
>97.0%(GC)
Packaging
5g
Price
$84
Updated
2021/12/16
TCI Chemical
Product number
I0562
Product name
Ethyl Isocyanoacetate
Purity
>97.0%(GC)
Packaging
25g
Price
$292
Updated
2021/12/16
Alfa Aesar
Product number
L15379
Product name
Ethyl isocyanoacetate, 98%
Packaging
5g
Price
$94.2
Updated
2021/12/16
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Ethyl isocyanoacetate Chemical Properties,Usage,Production

Chemical Properties

Light yellow to brom liquid

Uses

Ethyl Isocyanoacetate, is a cyclization synthon used to prepare pyrroles, oxazolines, benzodiazepines, oxazoles and imidazoles. Ethyl isocyanoacetate can be used to prepare pyrroles,1,2 oxazolines, benzodiazepines, oxazoles and imidazoles.

Uses

Ethyl isocyanoacetate is used in the syntheses of 7-aza-tetrahydroindoles, oxazolines, benzodiazepines, imidazoles and oxazoles. For example, it is involved in the synthesis of 1H-indole-2-carboxylate by condensing with 2-bromo benzenealdehyde using CuI as a catalyst. It is a precursor used in the preparation of ethyl thiazole-4-carboxylate upon reaction with O-ethyl thioformate.

Preparation

synthesis of ethyl isocyanoacetate
A solution containing N-formyl glycine ethyl ester (1, 1.31 g, 10 mmol), DIPEA (2.62 g, 20 mmol) and DMAP (0.45 g, 3 mmol) in dry DCM (10 mL) was loaded in a sample loop and combined with a second stream containing triphosgene (2, 0.98 g, 3.3 mmol) also dissolved in dry DCM (10 mL) at individual channel flow rates of 0.5 mL/min. The combined stream was directed into two linked 10 mL FEP reactor vessels to achieve a 20 minutes residence time at ambient temperature. The output was collect and the solvent was carefully evaporated to 80% of its total volume. The crude material was filtered through silica (5 g) and washed with DCM (2 × 10 mL) to obtain the salt-free product. The desired product 3 was obtained as dark yellow oil after evaporation of the organic phase (1.03 g, 91 % isolated yield, >97% purity by 1H NMR).

Ethyl isocyanoacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl isocyanoacetate Suppliers

Zhangjiagang huamao Fine chemical Co.,Ltd.
Tel
;
Fax
0512-58327206
Email
sales@huamao-chem.com;ydzhou0515@126.com
Country
China
ProdList
37
Advantage
58
Shanghai yongzeng technology co., LTD
Tel
021-65925639-
Fax
021-6528 2963
Email
sales@yongzchem.com
Country
China
ProdList
68
Advantage
58
Zhangjiagang Free Trade Zone Kailite Chemical Co., Ltd.
Tel
0512-58813106-
Fax
0512-58813106
Email
sales@clentchem.com
Country
China
ProdList
167
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60
Xinyi Quren Biomedical Technology Co., Ltd
Tel
Email
2924048582@qq.com
Country
China
ProdList
98
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58
Jinan Wald Chemical Co., Ltd.
Tel
0531-88773586-
Fax
053188773586
Email
304264064@qq.com
Country
China
ProdList
147
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58
Creasyn Finechem(Tianjin) Co., Ltd.
Tel
022-83945878-
Fax
022-83945176
Email
export@creasyn.com
Country
China
ProdList
784
Advantage
68
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
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76
PharmaBlock Sciences (Nanjing),Inc.
Tel
400-025-5188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
6456
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55
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Beijing Donghualituo Techonlogy Development Co.,Ltd.
Tel
010-88425576
Fax
(+86)-10-88425546
Email
sales@dhltchem.com
Country
China
ProdList
794
Advantage
59
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View Lastest Price from Ethyl isocyanoacetate manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
Ethyl isocyanoacetate 2999-46-4
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
20ton
Release date
2021-10-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
Ethyl isocyanoacetate 2999-46-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Ethyl isocyanoacetate 2999-46-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

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