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Ethyl isocyanoacetate

Product Name
Ethyl isocyanoacetate
CAS No.
2999-46-4
Chemical Name
Ethyl isocyanoacetate
Synonyms
Ethyl 2-isocyanoacetate;Isocyanoacetate;2-Oxo-2-ethoxyethyl isocyanide;HANSA ISN-0528;BIO-FARMA BF001872;ethyl isocyanzacetate;ETHYL ISOCYANOACETATE;EthylIsocyanoacetate>Ethylisocyanoacetate,98%;ethyl forMylaMinoacetate
CBNumber
CB7209404
Molecular Formula
C5H7NO2
Formula Weight
113.11
MOL File
2999-46-4.mol
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Ethyl isocyanoacetate Property

Boiling point:
194-196 °C (lit.)
Density 
1.035 g/mL at 25 °C (lit.)
vapor pressure 
61.7Pa at 25℃
refractive index 
n20/D 1.418(lit.)
Flash point:
184 °F
storage temp. 
2-8°C
form 
Liquid
color 
Clear amber to dark brown
Water Solubility 
Miscible with organic solvents. Slightly miscible with water.
Sensitive 
Moisture & Light Sensitive
BRN 
3588613
Exposure limits
NIOSH: IDLH 25 mg/m3
LogP
0.91 at 25℃
CAS DataBase Reference
2999-46-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/22-20/21/22
Safety Statements 
36/37/39-26-36/37-24/25
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
8-9-21
HazardClass 
6.1
PackingGroup 
III
HS Code 
29299090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
226319
Product name
Ethyl isocyanoacetate
Purity
95%
Packaging
5g
Price
$120
Updated
2023/01/07
Sigma-Aldrich
Product number
226319
Product name
Ethyl isocyanoacetate
Purity
95%
Packaging
25g
Price
$261
Updated
2023/01/07
TCI Chemical
Product number
I0562
Product name
Ethyl Isocyanoacetate
Purity
>97.0%(GC)
Packaging
5g
Price
$82
Updated
2023/01/07
TCI Chemical
Product number
I0562
Product name
Ethyl Isocyanoacetate
Purity
>97.0%(GC)
Packaging
25g
Price
$284
Updated
2023/01/07
Alfa Aesar
Product number
L15379
Product name
Ethyl isocyanoacetate, 98%
Packaging
5g
Price
$94.2
Updated
2021/12/16
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Ethyl isocyanoacetate Chemical Properties,Usage,Production

Chemical Properties

Light yellow to brom liquid. Slightly soluble in water and lye, miscible in ethanol and ether.

Uses

Ethyl Isocyanoacetate, is a cyclization synthon used to prepare pyrroles, oxazolines, benzodiazepines, oxazoles and imidazoles. Ethyl isocyanoacetate can be used to prepare pyrroles,1,2 oxazolines, benzodiazepines, oxazoles and imidazoles.

Uses

Ethyl isocyanoacetate is used in the syntheses of 7-aza-tetrahydroindoles, oxazolines, benzodiazepines, imidazoles and oxazoles. For example, it is involved in the synthesis of 1H-indole-2-carboxylate by condensing with 2-bromo benzenealdehyde using CuI as a catalyst. It is a precursor used in the preparation of ethyl thiazole-4-carboxylate upon reaction with O-ethyl thioformate.

Preparation

synthesis of ethyl isocyanoacetate
A solution containing N-formyl glycine ethyl ester (1, 1.31 g, 10 mmol), DIPEA (2.62 g, 20 mmol) and DMAP (0.45 g, 3 mmol) in dry DCM (10 mL) was loaded in a sample loop and combined with a second stream containing triphosgene (2, 0.98 g, 3.3 mmol) also dissolved in dry DCM (10 mL) at individual channel flow rates of 0.5 mL/min. The combined stream was directed into two linked 10 mL FEP reactor vessels to achieve a 20 minutes residence time at ambient temperature. The output was collect and the solvent was carefully evaporated to 80% of its total volume. The crude material was filtered through silica (5 g) and washed with DCM (2 × 10 mL) to obtain the salt-free product. The desired product 3 was obtained as dark yellow oil after evaporation of the organic phase (1.03 g, 91 % isolated yield, >97% purity by 1H NMR).

General Description

Material may darken upon storage

Ethyl isocyanoacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl isocyanoacetate Suppliers

Hebei Momojin Biological Technology Co., Ltd
Tel
13288715578
Email
angelia@hbmojin.com
Country
China
ProdList
1664
Advantage
58
Zhangjiagang huamao Fine chemical Co.,Ltd.
Tel
13962221965
Fax
0512-58327206
Email
sales@huamao-chem.com
Country
China
ProdList
40
Advantage
58
Shanghai yongzeng technology co., LTD
Tel
021-65925639 15921781258
Fax
021-6528 2963
Email
sales@yongzchem.com
Country
China
ProdList
69
Advantage
58
Zhangjiagang Free Trade Zone Kailite Chemical Co., Ltd.
Tel
+86-512-58813106 15862625988
Fax
0512-58813106
Email
sales@clentchem.com
Country
China
ProdList
192
Advantage
60
Hebei Mojin Biotechnology Co.,ltd.
Tel
15028179902 15028179902
Fax
18503279000
Email
bella@hbmojin.com
Country
China
ProdList
111
Advantage
58
Shanghai qiyan medicine technology co., ltd
Tel
15021941186
Email
3572772243@qq.com
Country
China
ProdList
174
Advantage
58
Shanghai Jiuju Chemical Technology Co. LTD
Tel
021-54290889 18117093889
Email
1261932215@qq.com
Country
China
ProdList
382
Advantage
58
Creasyn Finechem(Tianjin) Co., Ltd.
Tel
022-83946278 13820372920
Fax
022-83945176
Email
sales@creasyn.com
Country
China
ProdList
850
Advantage
68
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
PharmaBlock Sciences (Nanjing),Inc.
Tel
400-0255188 13770978108
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
6453
Advantage
55
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View Lastest Price from Ethyl isocyanoacetate manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
Ethyl isocyanoacetate 2999-46-4
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
20ton
Release date
2021-10-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
Ethyl isocyanoacetate 2999-46-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Ethyl isocyanoacetate 2999-46-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

2999-46-4, Ethyl isocyanoacetateRelated Search:


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