ChemicalBook > CAS DataBase List > Ethyl isocyanoacetate

Ethyl isocyanoacetate

Product Name
Ethyl isocyanoacetate
CAS No.
2999-46-4
Chemical Name
Ethyl isocyanoacetate
Synonyms
Ethyl 2-isocyanoacetate;Isocyanoacetate;2-Oxo-2-ethoxyethyl isocyanide;HANSA ISN-0528;BIO-FARMA BF001872;ethyl isocyanzacetate;ETHYL ISOCYANOACETATE;Ethylisocyanatoactate;EthylIsocyanoacetate>Ethylisocyanoacetate,98%
CBNumber
CB7209404
Molecular Formula
C5H7NO2
Formula Weight
113.11
MOL File
2999-46-4.mol
More
Less

Ethyl isocyanoacetate Property

Boiling point:
194-196 °C (lit.)
Density 
1.035 g/mL at 25 °C (lit.)
vapor pressure 
61.7Pa at 25℃
refractive index 
n20/D 1.418(lit.)
Flash point:
184 °F
storage temp. 
2-8°C
solubility 
Chloroform, Methanol (Slightly)
form 
Liquid
color 
Clear amber to dark brown
Water Solubility 
Miscible with organic solvents. Slightly miscible with water.
Sensitive 
Moisture & Light Sensitive
BRN 
3588613
Exposure limits
NIOSH: IDLH 25 mg/m3
LogP
0.91 at 25℃
CAS DataBase Reference
2999-46-4(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
20/22-20/21/22
Safety Statements 
36/37/39-26-36/37-24/25
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
8-9-21
HazardClass 
6.1
PackingGroup 
III
HS Code 
29299090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
226319
Product name
Ethyl isocyanoacetate
Purity
95%
Packaging
5g
Price
$125
Updated
2024/03/01
Sigma-Aldrich
Product number
226319
Product name
Ethyl isocyanoacetate
Purity
95%
Packaging
25g
Price
$272
Updated
2024/03/01
TCI Chemical
Product number
I0562
Product name
Ethyl Isocyanoacetate
Purity
>97.0%(GC)
Packaging
5g
Price
$86
Updated
2024/03/01
TCI Chemical
Product number
I0562
Product name
Ethyl Isocyanoacetate
Purity
>97.0%(GC)
Packaging
25g
Price
$296
Updated
2024/03/01
Alfa Aesar
Product number
L15379
Product name
Ethyl isocyanoacetate, 98%
Packaging
1g
Price
$36.1
Updated
2024/03/01
More
Less

Ethyl isocyanoacetate Chemical Properties,Usage,Production

Chemical Properties

Light yellow to brom liquid. Slightly soluble in water and lye, miscible in ethanol and ether.

Uses

Ethyl Isocyanoacetate, is a cyclization synthon used to prepare pyrroles, oxazolines, benzodiazepines, oxazoles and imidazoles. Ethyl isocyanoacetate can be used to prepare pyrroles,1,2 oxazolines, benzodiazepines, oxazoles and imidazoles.

Uses

Ethyl isocyanoacetate is used in the syntheses of 7-aza-tetrahydroindoles, oxazolines, benzodiazepines, imidazoles and oxazoles. For example, it is involved in the synthesis of 1H-indole-2-carboxylate by condensing with 2-bromo benzenealdehyde using CuI as a catalyst. It is a precursor used in the preparation of ethyl thiazole-4-carboxylate upon reaction with O-ethyl thioformate.

Preparation

synthesis of ethyl isocyanoacetate
A solution containing N-formyl glycine ethyl ester (1, 1.31 g, 10 mmol), DIPEA (2.62 g, 20 mmol) and DMAP (0.45 g, 3 mmol) in dry DCM (10 mL) was loaded in a sample loop and combined with a second stream containing triphosgene (2, 0.98 g, 3.3 mmol) also dissolved in dry DCM (10 mL) at individual channel flow rates of 0.5 mL/min. The combined stream was directed into two linked 10 mL FEP reactor vessels to achieve a 20 minutes residence time at ambient temperature. The output was collect and the solvent was carefully evaporated to 80% of its total volume. The crude material was filtered through silica (5 g) and washed with DCM (2 × 10 mL) to obtain the salt-free product. The desired product 3 was obtained as dark yellow oil after evaporation of the organic phase (1.03 g, 91 % isolated yield, >97% purity by 1H NMR).

General Description

Material may darken upon storage

Ethyl isocyanoacetate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Ethyl isocyanoacetate Suppliers

Hebei Mojin Biotechnology Co.,ltd.
Tel
0311-15028179902 15028179902
Fax
18503279000
Email
bella@hbmojin.com
Country
China
ProdList
110
Advantage
58
Zhangjiagang Free Trade Zone Kailite Chemical Co., Ltd.
Tel
18606289633 15862625988
Fax
0512-58813106
Email
sales@clentchem.com
Country
China
ProdList
181
Advantage
60
Shanghai qiyan medicine technology co., ltd
Tel
15021941186
Email
3572772243@qq.com
Country
China
ProdList
190
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Beijing Donghualituo Techonlogy Development Co.,Ltd.
Tel
010-88425576
Fax
(+86)-10-88425546
Email
sales@dhltchem.com
Country
China
ProdList
793
Advantage
59
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Zhangjiagang BoMan Chemical Co., Ltd.
Tel
15601563028
Fax
4006648400-2
Country
China
ProdList
29
Advantage
60
More
Less

View Lastest Price from Ethyl isocyanoacetate manufacturers

Hebei Fengqiang Trading Co., LTD
Product
Ethyl isocyanoacetate 2999-46-4
Price
US $100.00/drum
Min. Order
1drum
Purity
99
Supply Ability
5000
Release date
2023-08-30
Hebei Mojin Biotechnology Co., Ltd
Product
Ethyl isocyanoacetate 2999-46-4
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
20ton
Release date
2021-10-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
Ethyl isocyanoacetate 2999-46-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

2999-46-4, Ethyl isocyanoacetateRelated Search:


  • Acetic acid, isocyano-, ethyl ester
  • Ethylisocyanoacetate,98%
  • Isocyanoacetate
  • ethyl isocyanoacetate 2999-46-4
  • (2-Oxo-2-ethoxyethyl) isocyanide
  • 2-Oxo-2-ethoxyethyl isocyanide
  • Ethoxycarbonylmethyl isocyanide
  • Ethyl 2-isocyanoacetate
  • ethyl isocyanzacetate
  • Ethyl isocyanoacetate,97%
  • Ethyl isocyanoacetate,99+%
  • ethyl forMylaMinoacetate
  • Ethyl isocyanoacetate, 97% 5GR
  • Acetic acid, 2-isocyano-, ethyl ester
  • Ethyl isocyanoacetate(EICA)
  • Isocyanoacetic acid ethyl ester, Ethyl 2-isocyanoethanoate
  • BIO-FARMA BF001872
  • HANSA ISN-0528
  • ISOCYANOACETIC ACID ETHYL ESTER
  • ETHYL ISOCYANOACETATE
  • Ethyl isocyanoacetate 95%
  • Ethyl isocyanoacetate FP170213
  • Ethyl Isocyanoacetate, 95+%
  • EthylIsocyanoacetate&gt
  • TIANFU-CHEM - Ethyl isocyanoacetate
  • Isocyanoacetic acid ethyl este
  • Ethylisocyanatoactate
  • 2999-46-4
  • CNCH2COOCH2CH3
  • CNCH2CO2CH2CH3
  • ISOCYANATE
  • Building Blocks
  • Nitrogen Compounds
  • Isocyanides
  • Organic Building Blocks
  • Building Blocks
  • Chemical Synthesis
  • Nitrogen Compounds
  • Organic Building Blocks
  • fine chemicals, specialty chemicals, intermediates, electronic chemical, organic synthesis
  • straight chain compounds
  • pharmacetical
  • Naphthyridine,Quinoline
  • Isocyanides
  • Nitrogen Compounds
  • Organic Building Blocks