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Ethyl isocyanoacetate

Product Name
Ethyl isocyanoacetate
CAS No.
2999-46-4
Chemical Name
Ethyl isocyanoacetate
Synonyms
Ethyl 2-isocyanoacetate;Isocyanoacetate;2-Oxo-2-ethoxyethyl isocyanide;HANSA ISN-0528;BIO-FARMA BF001872;ethyl isocyanzacetate;ETHYL ISOCYANOACETATE;Ethylisocyanatoactate;EthylIsocyanoacetate>Ethylisocyanoacetate,98%
CBNumber
CB7209404
Molecular Formula
C5H7NO2
Formula Weight
113.11
MOL File
2999-46-4.mol
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Ethyl isocyanoacetate Property

Boiling point:
194-196 °C (lit.)
Density 
1.035 g/mL at 25 °C (lit.)
vapor pressure 
61.7Pa at 25℃
refractive index 
n20/D 1.418(lit.)
Flash point:
184 °F
storage temp. 
2-8°C
solubility 
Chloroform, Methanol (Slightly)
form 
Liquid
color 
Clear amber to dark brown
Water Solubility 
Miscible with organic solvents. Slightly miscible with water.
Sensitive 
Moisture & Light Sensitive
BRN 
3588613
Exposure limits
NIOSH: IDLH 25 mg/m3
LogP
0.91 at 25℃
CAS DataBase Reference
2999-46-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/22-20/21/22
Safety Statements 
36/37/39-26-36/37-24/25
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
8-9-21
HazardClass 
6.1
PackingGroup 
III
HS Code 
29299090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
226319
Product name
Ethyl isocyanoacetate
Purity
95%
Packaging
5g
Price
$125
Updated
2024/03/01
Sigma-Aldrich
Product number
226319
Product name
Ethyl isocyanoacetate
Purity
95%
Packaging
25g
Price
$272
Updated
2024/03/01
TCI Chemical
Product number
I0562
Product name
Ethyl Isocyanoacetate
Purity
>97.0%(GC)
Packaging
5g
Price
$86
Updated
2024/03/01
TCI Chemical
Product number
I0562
Product name
Ethyl Isocyanoacetate
Purity
>97.0%(GC)
Packaging
25g
Price
$296
Updated
2024/03/01
Alfa Aesar
Product number
L15379
Product name
Ethyl isocyanoacetate, 98%
Packaging
1g
Price
$36.1
Updated
2024/03/01
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Ethyl isocyanoacetate Chemical Properties,Usage,Production

Chemical Properties

Light yellow to brom liquid. Slightly soluble in water and lye, miscible in ethanol and ether.

Uses

Ethyl Isocyanoacetate, is a cyclization synthon used to prepare pyrroles, oxazolines, benzodiazepines, oxazoles and imidazoles. Ethyl isocyanoacetate can be used to prepare pyrroles,1,2 oxazolines, benzodiazepines, oxazoles and imidazoles.

Uses

Ethyl isocyanoacetate is used in the syntheses of 7-aza-tetrahydroindoles, oxazolines, benzodiazepines, imidazoles and oxazoles. For example, it is involved in the synthesis of 1H-indole-2-carboxylate by condensing with 2-bromo benzenealdehyde using CuI as a catalyst. It is a precursor used in the preparation of ethyl thiazole-4-carboxylate upon reaction with O-ethyl thioformate.

Preparation

synthesis of ethyl isocyanoacetate
A solution containing N-formyl glycine ethyl ester (1, 1.31 g, 10 mmol), DIPEA (2.62 g, 20 mmol) and DMAP (0.45 g, 3 mmol) in dry DCM (10 mL) was loaded in a sample loop and combined with a second stream containing triphosgene (2, 0.98 g, 3.3 mmol) also dissolved in dry DCM (10 mL) at individual channel flow rates of 0.5 mL/min. The combined stream was directed into two linked 10 mL FEP reactor vessels to achieve a 20 minutes residence time at ambient temperature. The output was collect and the solvent was carefully evaporated to 80% of its total volume. The crude material was filtered through silica (5 g) and washed with DCM (2 × 10 mL) to obtain the salt-free product. The desired product 3 was obtained as dark yellow oil after evaporation of the organic phase (1.03 g, 91 % isolated yield, >97% purity by 1H NMR).

General Description

Material may darken upon storage

Ethyl isocyanoacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl isocyanoacetate Suppliers

TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28398
Advantage
80
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View Lastest Price from Ethyl isocyanoacetate manufacturers

Hebei Duling International Trade Co. LTD
Product
Ethyl isocyanoacetate 2999-46-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 Ton
Release date
2023-02-20
Hebei Fengqiang Trading Co., LTD
Product
Ethyl isocyanoacetate 2999-46-4
Price
US $100.00/drum
Min. Order
1drum
Purity
99
Supply Ability
5000
Release date
2023-08-30
Hebei Mojin Biotechnology Co., Ltd
Product
Ethyl isocyanoacetate 2999-46-4
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
20ton
Release date
2021-10-09

2999-46-4, Ethyl isocyanoacetateRelated Search:


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