ChemicalBook > CAS DataBase List > Cyanoacetic acid

Cyanoacetic acid

Product Name
Cyanoacetic acid
CAS No.
372-09-8
Chemical Name
Cyanoacetic acid
Synonyms
CYAD;NCCH2COOH;usafkf-17;USAF kf-17;Cyanoacetic;Cyanessigsure;2-cyanoacetate;CYANOCETIC ACID;Cyanessigsaeure;cyano-aceticaci
CBNumber
CB8217349
Molecular Formula
C3H3NO2
Formula Weight
85.06
MOL File
372-09-8.mol
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Cyanoacetic acid Property

Melting point:
65 °C
Boiling point:
108 °C0.15 mm Hg(lit.)
Density 
1.3676 (rough estimate)
vapor pressure 
0.1 mm Hg ( 100 °C)
refractive index 
1.3764 (estimate)
Flash point:
226 °F
storage temp. 
Store below +30°C.
solubility 
H2O: soluble50mg/mL, clear, colorless to very faintly yellow
pka
2.45(at 25℃)
form 
Adhering Crystalline Solid
color 
White to light beige
PH
1.6 (50g/l, H2O, 20℃)
Water Solubility 
1000 g/L (20 ºC)
Sensitive 
Hygroscopic
Merck 
14,2689
BRN 
506325
InChIKey
MLIREBYILWEBDM-UHFFFAOYSA-N
CAS DataBase Reference
372-09-8(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, cyano-(372-09-8)
EPA Substance Registry System
Cyanoacetic acid (372-09-8)
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Safety

Hazard Codes 
C
Risk Statements 
22-31-34-52/53-20/22
Safety Statements 
26-36/37/39-45-61-20
RIDADR 
UN 3261 8/PG 2
WGK Germany 
2
RTECS 
AG3675000
3-10-21
TSCA 
Yes
HS Code 
2926 90 70
HazardClass 
8
PackingGroup 
II
Hazardous Substances Data
372-09-8(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 1500 mg/kg LD50 dermal Rabbit > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H332Harmful if inhaled

H402Harmful to aquatic life

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P310Immediately call a POISON CENTER or doctor/physician.

P390Absorb spillage to prevent material damage.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.00252
Product name
Cyanoacetic acid
Purity
for synthesis
Packaging
250 g
Price
$45.6
Updated
2021/12/16
Sigma-Aldrich
Product number
C88505
Product name
Cyanoacetic acid
Purity
99%
Packaging
25g
Price
$58.2
Updated
2021/12/16
Sigma-Aldrich
Product number
8.00252
Product name
Cyanoacetic acid
Purity
for synthesis
Packaging
1 kg
Price
$93.42
Updated
2021/12/16
Sigma-Aldrich
Product number
C88505
Product name
Cyanoacetic acid
Purity
99%
Packaging
1kg
Price
$164
Updated
2021/12/16
Sigma-Aldrich
Product number
C88505
Product name
Cyanoacetic acid
Purity
99%
Packaging
500g
Price
$104
Updated
2021/03/22
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Cyanoacetic acid Chemical Properties,Usage,Production

Description

Cyanoacetic acid is an organic compound. It is a white, hygroscopic solid. The compound contains two functional groups, a nitrile (C≡N) and a carboxylic acid. It is a precursor to cyanoacrylates, components of adhesives.
Cyanoacetic acid is used in pharmaceutical industry for producing vitamin B6 and caffeine. It is also used in making dyes, agricultural chemicals, and in the synthesis of phenylacetic acid esters. It acts as a precursor cyanoacrylates viz. ethyl cyanoacrylate.

Chemical Properties

white to light beige adhering crystalline solid

Uses

Cyanoacetic acid was used in the synthesis of N-piperidine-cyanacetamide and N-morpholyl-cyanacetamide. It was also used in the preparation of a panchromatic dye for dye-sensitized solar cells.

Uses

Synthesis of intermediates; manufacture of barbital.

Uses

Cyanoacetic acid is used in pharmaceutical industry for producing vitamin B6 and caffeine. It is also used in making dyes, agricultural chemicals, and in the synthesis of phenylacetic acid esters. It acts as a precursor cyanoacrylates viz. ethyl cyanoacrylate.

Application

Cyanoacetic acid can be used as a reagent:
Along with acetic anhydride for cyanoacetylation of various pyrroles, indoles, and aniline derivatives. It can also be used in other reactions such as cyclizations, syntheses of coumarins and other heterocycles.
To prepare of key intermediate via Knoevenagel condensation in the total synthesis of 5-acetamido-substituted melatonin derivatives as MT3 receptor ligands.
In the synthesis of aminopyrrolinone derivatives by reacting Ugi adducts of cyanoacetic acid and aromatic aldehydes.

Preparation

Cyanoacetic acid is prepared by treatment of chloroacetate salts with sodium cyanide followed by acidification. Electrosynthesis by cathodic reduction of carbon dioxide and anodic oxidation of acetonitrile also affords cyanoacetic acid.

Definition

ChEBI: A monocarboxylic acid that consists of acetic acid bearing a cyano substituent.

General Description

Yellow-brown liquid with an unpleasant odor. Sinks and mixes with water.

Air & Water Reactions

Water soluble.

Reactivity Profile

White, moderately toxic solid, combustible. When heated to decomposition Cyanoacetic acid emits toxic fumes of nitrile and oxides of nitrogen. A stirred mixture with furfuryl alcohol exploded violently upon heating [MCA Case History No 858].

Health Hazard

Contact irritates eyes and may irritate skin.

Fire Hazard

Special Hazards of Combustion Products: Toxic oxides of nitrogen and toxic and flammable acetonitrile vapors may form in fire.

Purification Methods

Recrystallise the acid to constant melting point from *benzene/acetone (2:3), and dry it over silica gel. [Beilstein 2 H 583, 2 I 253, 2 II 530, 2 III 1626, 2 IV 1888.]

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Cyanoacetic acid Suppliers

-Hebei Integrity Group Co., Ltd.
Tel
0311-84626641
Fax
0311-8462664
Email
chengxin@hebeichengxin.com
Country
China
ProdList
1
Advantage
58
Shanghai Kaisai Chemical Co., Ltd
Tel
021-33516711;021-33516722
Fax
021-33516776
Email
kaisaichem1@163.com;kaisaichem1@163.com
Country
China
ProdList
4719
Advantage
58
Hubei Smer Pharmaceutical Technology Co., Ltd.
Tel
;
Email
826455094@qq.com;2418579533@qq.com
Country
China
ProdList
474
Advantage
58
Weifang Qianyuan Biotechnology Co., Ltd.
Tel
Email
1297429207@qq.com
Country
China
ProdList
294
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2213
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
+86-021-61259100
Fax
86-21-61259102
Email
int02@meryer.com
Country
China
ProdList
40264
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 qq:2355568890
Fax
0086-21-50182339
Email
sales@demochem.com; export1@demochem.com
Country
China
ProdList
2582
Advantage
57
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View Lastest Price from Cyanoacetic acid manufacturers

Hebei Guanlang Biotechnology Co., Ltd.
Product
Cyanoacetic acid 372-09-8
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2021-07-21
Zhuozhou Wenxi import and Export Co., Ltd
Product
Cyanoacetic acid 372-09-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Shaanxi Dideu Medichem Co. Ltd
Product
Cyanoacetic acid 372-09-8
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-01-02

372-09-8, Cyanoacetic acidRelated Search:


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