description Stability and Reactivity: HUMAN USE AND EXPERIENCE Metabolism/Pharmacokinetics
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Sodium chloroacetate

description Stability and Reactivity: HUMAN USE AND EXPERIENCE Metabolism/Pharmacokinetics
Product Name
Sodium chloroacetate
CAS No.
3926-62-3
Chemical Name
Sodium chloroacetate
Synonyms
sma;SODIUM MONOCHLOROACETATE;sodiuM 2-chloroacetate;smca;SODIUM MONOCHLORACETATE;CHLOROACETIC ACID SODIUM SALT;SMN;SMA3;SMA2;SMA1
CBNumber
CB9853591
Molecular Formula
C2H2ClNaO2
Formula Weight
116.48
MOL File
3926-62-3.mol
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Sodium chloroacetate Property

Melting point:
199 °C (dec.)(lit.)
Density 
1.87[at 20℃]
vapor pressure 
0.001Pa at 20℃
Flash point:
270°C
storage temp. 
-20°C
solubility 
820g/l
form 
Crystalline Powder
color 
White
PH
4.5-9.0 (50g/l, H2O, 20℃)
Water Solubility 
440 g/L (20 ºC)
Sensitive 
Hygroscopic
Merck 
14,2112
BRN 
3597157
Stability:
Stable. Incompatible with strong oxidizing agents.
LogP
-3.8 at 20℃
CAS DataBase Reference
3926-62-3(CAS DataBase Reference)
EPA Substance Registry System
Sodium chloroacetate (3926-62-3)
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Safety

Hazard Codes 
T,N
Risk Statements 
25-38-50-36
Safety Statements 
22-37-45-61-26
RIDADR 
UN 2659 6.1/PG 3
WGK Germany 
2
RTECS 
AG1400000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29154000
Toxicity
LD50 orally in Rabbit: 95 mg/kg LD50 dermal Rat > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H400Very toxic to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.20293
Product name
Sodium chloroacetate
Purity
for synthesis
Packaging
100g
Price
$40
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20293
Product name
Sodium chloroacetate
Purity
for synthesis
Packaging
500g
Price
$53.6
Updated
2024/03/01
Sigma-Aldrich
Product number
291773
Product name
Sodium chloroacetate
Purity
98%
Packaging
1kg
Price
$55
Updated
2024/03/01
Sigma-Aldrich
Product number
291773
Product name
Sodium chloroacetate
Purity
98%
Packaging
3kg
Price
$134
Updated
2024/03/01
Alfa Aesar
Product number
A12379
Product name
Sodium chloroacetate, 98%
Packaging
250g
Price
$22.9
Updated
2024/03/01
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Sodium chloroacetate Chemical Properties,Usage,Production

description

Sodium chloroacetate is a white colored powdered solid. It is soluble in water. It may be toxic ingestion or inhalation. It is used as a contact herbicide and a component in other herbicides, an intermediate in the production of carboxymethyl-cellulose, and other synthetic organic chemicals.

In one study systemic effects to Sprague-Dawley rats (M/F, numbers per group not indicated) given single doses of sodium chloroacetate at 94, 282, or 470 mg/kg bw demonstrated increased sodium concentration in urine, increased potassium concentration in plasma, and reduced glutathione level in the liver at the highest dose; 2/3 of males died within 24 hours of treatment in the middle and high dose groups.

Stability and Reactivity:

Sodium chloroacetate is stable at normal temperatures and  pressures. Incompatible with oxidizing agents, reducing  agents.

HUMAN USE AND EXPERIENCE

There are a number of case studies of the parent compound,  monochloroacetic acid (MCA), involving corrosion of skin and  eyes and fatalities related to skin absorption of toxicologically  significant amounts of MCA and a health-based target  concentration of 0.1 mg/L was calculated for MCA in drinking  water although Health Canada and Environment Canada have  categorized MCA as not entering the environment at levels that  may be hazardous to human health. There are, however, no  similar data or epidemiological reports for sodium  chloroacetate.

Metabolism/Pharmacokinetics

After absorption, monochloroacetic acid (parent compound  CAS 79-11-8) is converted to thiodiacetic acid and glycolic acid  and is accumulated in the liver and kidneys of rats.Metabolism of sodium monochloroacetate is expected to have a  similar pharmacokinetic profile.

Chemical Properties

Sodium chloroacetate is a white crystalline powder. It is soluble in water. It may be toxic ingestion or inhalation.
Sodium chloroacetate is a reactive and toxic material, so it is hydrolyzed to glycolic acid nearly quantitatively at the end of the production cycle. Chloroacetic acid always contains traces of dichloroacetic acid, a toxic and unreactive material that appears on the California Prop.65 list.

Uses

Sodium chloroacetate is the sodium salt of chloroacetic acid. It is used to prepare weed killers, dyes, vitamins and active pharmaceutical ingredients. It is also used as an odor agent, surface active agent and viscosity adjustor. Sodium dihydroxyethyltallow glycinate is the condensation product of dihydroxyethyl tallow amine and sodiumchloroacetate.It is used as a thickeningagent and asurfactant.

Uses

Sodium chloroacetate is used to prepare dyes and active pharmaceutical ingredients. It is also used as an odor agent, surface active agent and viscosity adjustor.

General Description

Chloroacetic acid sodium salt is a white colored powdered solid. Chloroacetic acid sodium salt is soluble in water.Chloroacetic acid sodium salt may be toxic ingestion or inhalation. Sodium chloroacetate is used as a contact herbicide and a component in other herbicides, an intermediate in the production of carboxymethyl-cellulose, and other synthetic organic chemicals.

Air & Water Reactions

Chloroacetic acid sodium salt is soluble in water.

Reactivity Profile

Salts, basic, such as Chloroacetic acid sodium salt, are generally soluble in water. The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids. These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

Health Hazard

Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

Actin plays an important role in cell motility, structure and integrity. Smooth muscle actin-α (SMA)/ α2-smooth muscle actin (ACTA2) interacts with β-myosin heavy chain and helps in vascular smooth muscle cell contraction. The encoded protein modulates the expression of c-MET (tyrosine-protein kinase Met) and focal adhesion kinase (FAK) in human lung adenocarcinoma cells, which positively and selectively mediates tumor progression. Mutation in the gene expression leads to thoracic aortic aneurysms and dissections (TAAD).

Safety Profile

Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of Cland NazO. Used as an herbicide

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Sodium chloroacetate Suppliers

SHANDONGQIANGSENHUAGONG
Tel
0533-18369966222-222 18369966222
Email
3034942636@qq.com
Country
China
ProdList
922
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58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
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65
Shandong Xuchen Chemical Technology Co. Ltd
Tel
0533-13853380-763 13853380763
Email
3523649491@qq.com
Country
China
ProdList
390
Advantage
58
ZI BO YUJIN TRADING CO.,LTD
Tel
18805331268
Email
691775164@qq.com
Country
China
ProdList
508
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58
ZIBO LISHUO CHEMICAL
Tel
13853320569
Email
z1184400177@163.com
Country
China
ProdList
835
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58
Shandong Baiyang Biotechnology Co., Ltd
Tel
0533-13505335043 13505335043
Email
jinqiu9966@163.com
Country
China
ProdList
86
Advantage
58
Shandong Johnson Chemical Co., LTD
Tel
0533-1516922-6111 15169226111
Email
676807278@qq.com
Country
China
ProdList
748
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58
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2963
Advantage
65
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View Lastest Price from Sodium chloroacetate manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Sodium chloroacetate 3926-62-3
Price
US $10.00-2.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-28
Hebei Weibang Biotechnology Co., Ltd
Product
Sodium chloroacetate 3926-62-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2023-02-16
Hebei Mojin Biotechnology Co., Ltd
Product
Sodium chloroacetate 3926-62-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-11-10

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