Dimethyl malonate
- Product Name
- Dimethyl malonate
- CAS No.
- 108-59-8
- Chemical Name
- Dimethyl malonate
- Synonyms
- DMM;METHYL MALONATE;Dimethyl propanedioate;MALONIC ACID DIMETHYL ESTER;dimthyl malonate;dimethyl1,3-propanedioate;MINA-009;Malonic acid d;DIMETHYL MALONAT;DIMETHYL MALONATE
- CBNumber
- CB3776436
- Molecular Formula
- C5H8O4
- Formula Weight
- 132.11
- MOL File
- 108-59-8.mol
Dimethyl malonate Property
- Melting point:
- -62 °C (lit.)
- Boiling point:
- 180-181 °C (lit.)
- Density
- 1.156 g/mL at 25 °C (lit.)
- vapor density
- >1 (vs air)
- vapor pressure
- 0.15 hPa (20 °C)
- refractive index
- n20/D 1.413(lit.)
- Flash point:
- 194 °F
- storage temp.
- Store below +30°C.
- solubility
- alcohol: miscible
- pka
- 11.80±0.46(Predicted)
- form
- Liquid
- color
- Clear colorless
- Odor
- fruity
- explosive limit
- 1.3-17.4%(V)
- Water Solubility
- negligible
- Merck
- 14,6096
- BRN
- 774261
- Dielectric constant
- 10.4（20℃）
- Stability:
- Stable. Incompatible with strong oxidizing agents. Flammable.
- InChIKey
- BEPAFCGSDWSTEL-UHFFFAOYSA-N
- LogP
- -0.05 at 20-25℃ and pH6.4
- CAS DataBase Reference
- 108-59-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Propanedioic acid, dimethyl ester(108-59-8)
- EPA Substance Registry System
- Dimethyl malonate (108-59-8)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 8.00899
- Product name
- Dimethyl malonate
- Purity
- for synthesis
- Packaging
- 100mL
- Price
- $35.3
- Updated
- 2024/03/01
- Product number
- 8.00899
- Product name
- Dimethyl malonate
- Purity
- for synthesis
- Packaging
- 500mL
- Price
- $64.9
- Updated
- 2024/03/01
- Product number
- 8.00899
- Product name
- Dimethyl malonate
- Purity
- for synthesis
- Packaging
- 1L
- Price
- $127
- Updated
- 2024/03/01
- Product number
- 136441
- Product name
- Dimethyl malonate
- Purity
- 98%
- Packaging
- 1kg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- M0030
- Product name
- Dimethyl Malonate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $19
- Updated
- 2024/03/01
Dimethyl malonate Chemical Properties,Usage,Production
Description
Dimethyl malonate is a diester derivative of malonic acid. It is a common reagent for organic synthesis used, for example, as a precursor for barbituric acid. It is also used in the malonic ester synthesis. It can be synthesized from dimethoxymethane and carbon monoxide.
Chemical Properties
liquid
Chemical Properties
Dimethyl malonate is soluble in alcohol and ether and very slightly soluble in water. It may slowly decompose.
Uses
It is used in fragrances and some artificial flavorings .
Uses
Dimethyl malonate is a reagent used in organic synthesis. It acts as a precursor for the synthesis of mono-substituted and di-substituted acetic acid, barbiturates, vitamin B1 and vitamin B6. It is used in the pharmaceutical industry to prepare pharmaceuticals like chloroquine and butazolidin. It is involved in the synthesis of diastereomeric pure thienylpyridines by reacting with 1,3-diphenylprop-2-enyl acetate.
Application
Dimethyl malonate undergoes enantioselective palladium-catalyzed allylic substitution reaction with 1,3-diphenylprop-2-enyl acetate to yield diastereomeric pure thienylpyridines.
Dimethyl malonate was used in gold catalyzed oxidative esterification of glycerol, 1,2-propanediol and 1,3-propanediol.
Production Methods
Dimethyl malonate is produced via direct esterification of methanol with malonic acid under azeotropic conditions.
General Description
Dimethyl malonate undergoes enantioselective palladium-catalyzed allylic substitution reaction with 1,3-diphenylprop-2-enyl acetate to yield diastereomeric pure thienylpyridines.
Dimethyl malonate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Dimethyl malonate manufacturers
- Product
- Dimethyl malonate 108-59-8
- Price
- US $6.00-0.60/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-18
- Product
- Dimethyl malonate 108-59-8
- Price
- US $30.00/KG
- Min. Order
- 1KG
- Purity
- >99%
- Supply Ability
- 20tons
- Release date
- 2023-03-13
- Product
- Dimethyl malonate 108-59-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2023-06-26