2-Methylpropanedioic acid

Product Name: 2-Methylpropanedioic acid
CAS No.: 516-05-2
Chemical Name: 2-Methylpropanedioic acid
Synonyms: METHYLMALONIC ACID;2-Methylmalonic acid;AI315327;onic acid;NSC 25201;AI3 15327;AI3-15327;Methylmalonic;isosuccinicacid;Isosuccinic acid
CBNumber: CB5713714
Molecular Formula: C4H6O4
Formula Weight: 118.09
MOL File: 516-05-2.mol

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2-Methylpropanedioic acid Property

Melting point:: 128-130 °C (lit.)
Boiling point:: 272.71°C (rough estimate)
Density: 1.45
refractive index: 1.4304 (estimate)
Flash point:: 2℃
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Crystalline Powder
pka: 3.07, 5.76(at 25℃)
color: White
Specific Gravity: 1.455
PH: 3.23(1 mM solution);2.6(10 mM solution);2.05(100 mM solution)
Water Solubility: soluble
BRN: 1756084
CAS DataBase Reference: 516-05-2(CAS DataBase Reference)
NIST Chemistry Reference: Methylmalonic acid(516-05-2)

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Safety

Hazard Codes: Xi,Xn,F
Risk Statements: 36/37/38-36-20/21/22-11
Safety Statements: 26-36/37-16
RIDADR: UN 1648 3 / PGII
WGK Germany: 3
RTECS: OO1400000
HS Code: 29171900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M54058
Product name: Methylmalonic acid
Purity: 99%
Packaging: 5g
Price: $65.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: M-080
Product name: Methylmalonic acid solution
Purity: 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $113
Updated: 2024/03/01

TCI Chemical

Product number: M0568
Product name: Methylmalonic Acid
Purity: >98.0%(T)
Packaging: 25g
Price: $74
Updated: 2024/03/01

Cayman Chemical

Product number: 14885
Product name: Methylmalonate
Purity: ≥95%
Packaging: 1g
Price: $20
Updated: 2024/03/01

Cayman Chemical

Product number: 14885
Product name: Methylmalonate
Purity: ≥95%
Packaging: 5g
Price: $48
Updated: 2024/03/01

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2-Methylpropanedioic acid Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

Methylmalonic acid can be used as a substrate in:

Esterification reactions by various catalysts.
Synthesis of pyrimidinium betaines with formamidine.
Synthesis of malonic acid half thioester (MAHT).

Uses

2-Methylpropanedioic acid binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.

Definition

ChEBI: Methylmalonic acid is a dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group. It has a role as a human metabolite. It is functionally related to a malonic acid. It is a conjugate acid of a methylmalonate(1-).

Biological Functions

Methylmalonic acid is capable of diffusing out of cells in which it is being produced, so it may be detected in excess in the blood, CSF, and urine of patients with these various forms of the disease.

General Description

Methylmalonic acid is an indicator of vitamin B₁₂ deficiency and methylmalonic acidemia. This Certified Spiking Solution^? is suitable for use in preparation of calibrators or controls in clinical and diagnostic testing using GC/MS or LC/MS.

storage

Store at RT

Purification Methods

The acid crystallises as the hydrate from water. [Beilstein 2 IV 1932.]

2-Methylpropanedioic acid Preparation Products And Raw materials

Raw materials

Preparation Products

cyclamen aldehyde

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2-Methylpropanedioic acid Suppliers

Americas 1 Belgium 1 Canada 1 China 235 Europe 3 Germany 1 India 7 Japan 5 Norway 1 Slovakia 1 South Korea 1 Switzerland 1 United Kingdom 8 United States 36 USA 1 Global 303

Hubei Hongxin Ruiyu Fine Chemical Co., Ltd.

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Jiaxing Jilat Chemical Co. LTD

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Beijing Donghualituo Techonlogy Development Co.,Ltd.

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TCI (Shanghai) Development Co., Ltd.

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Beijing dtftchem Technology Co., Ltd.

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View Lastest Price from 2-Methylpropanedioic acid manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: 2-Methylpropanedioic acid 516-05-2
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-15

Xiamen Yunfan Biotech Co.,Ltd.

Product: 2-Methylpropanedioic acid 516-05-2
Price: US $0.00-0.00/KG
Min. Order: 5KG
Purity: 99%
Supply Ability: 1000 kg/Month
Release date: 2024-05-15

Hebei Mojin Biotechnology Co., Ltd

Product: 2-Methylpropanedioic acid 516-05-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-24

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516-05-2 2-Methylpropanedioic acid C4H6O4

AI3 15327

AI315327

AI3-15327

NSC 25201|||MMA|||Isosuccinic acid|||Methylpropanedioic acid|||Methylmalonate

Methylmalonic acid in methanol

Methylmalonic Acid in Acetonitrile

Methyl Malonic Acid / 2-Methylpropanedioc acid

516-05-2

HOOCCHCH3COOH

CH3CHCO2H2

Carboxylic Acids

Carbonyl Compounds

C1 to C5

Building Blocks

Organic Building Blocks

Building Blocks

C1 to C5

Carbonyl Compounds

Carboxylic Acids

Chemical Synthesis

Organic Building Blocks

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

API intermediates

Aliphatics

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals