Synthesis
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2,4-Difluoronitrobenzene

Synthesis
Product Name
2,4-Difluoronitrobenzene
CAS No.
446-35-5
Chemical Name
2,4-Difluoronitrobenzene
Synonyms
2,4-DIFLUORO-1-NITROBENZENE;2.4 DFNB;2,4-Difluoronitroben;3,5-diflurobenzonitrile;2,4-Difluronitrobenzene;2,4-Difluoronitribenzene;2,4-DIFLUORO NITROBENZEN;2,4-DIFLUORONITROBENZENE;Flurbiprofen Impurity 24;1,3-Difluor-4-nitrobenzol
CBNumber
CB0722917
Molecular Formula
C6H3F2NO2
Formula Weight
159.09
MOL File
446-35-5.mol
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2,4-Difluoronitrobenzene Property

Melting point:
9-10 °C (lit.)
Boiling point:
203-204 °C (lit.)
Density 
1.451 g/mL at 25 °C (lit.)
vapor density 
>1 (vs air)
refractive index 
n20/D 1.511(lit.)
Flash point:
195 °F
storage temp. 
Sealed in dry,Room Temperature
form 
clear liquid
color 
Light yellow to Brown
Specific Gravity
1.45
Water Solubility 
Insoluble in water.
BRN 
2048034
Stability:
Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.
InChIKey
RJXOVESYJFXCGI-UHFFFAOYSA-N
CAS DataBase Reference
446-35-5(CAS DataBase Reference)
NIST Chemistry Reference
2,4-Difluoronitrobenzene(446-35-5)
EPA Substance Registry System
2,4-Difluoronitrobenzene (446-35-5)
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Safety

Hazard Codes 
T,Xi,Xn
Risk Statements 
25-36/37/38-23/24/25-20/21/22
Safety Statements 
26-45-36/37/39-23
RIDADR 
UN 2810 6.1/PG 1
WGK Germany 
3
RTECS 
CZ5730000
Hazard Note 
Irritant
TSCA 
T
HazardClass 
6.1
PackingGroup 
III
HS Code 
29049090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
233226
Product name
2,4-Difluoronitrobenzene
Purity
99%
Packaging
25g
Price
$20.16
Updated
2024/03/01
Sigma-Aldrich
Product number
233226
Product name
2,4-Difluoronitrobenzene
Purity
99%
Packaging
100g
Price
$73.8
Updated
2024/03/01
TCI Chemical
Product number
D1636
Product name
2,4-Difluoronitrobenzene
Purity
>99.0%(GC)
Packaging
25g
Price
$19
Updated
2024/03/01
TCI Chemical
Product number
D1636
Product name
2,4-Difluoronitrobenzene
Purity
>99.0%(GC)
Packaging
500g
Price
$126
Updated
2024/03/01
Alfa Aesar
Product number
A13249
Product name
2,4-Difluoro-1-nitrobenzene, 98%
Packaging
25g
Price
$30.65
Updated
2024/03/01
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2,4-Difluoronitrobenzene Chemical Properties,Usage,Production

Synthesis

KF with n-Hexadecyltrimethylammonium bromide as the PTC has been shown recently to work in dimethylformamide (DMF), important owing to the low cost16 of DMF.

Chemical Properties

yellow liquid

Uses

2,4-Difluoronitrobenzene has been used in the synthesis of: 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction; (±)-horsfiline; resin-bound 2-arylaminobenzimidazoles.
2,?4-?Difluoronitrobenzene is a reactant in the preparation of 4-?thiazolidinone derivatives as antimicrobial agents.

Uses

2,4-Difluoronitrobenzene has been used in the synthesis of 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction, (±)-horsfiline and resin-bound-2-arylaminobenzimidazoles.

Uses

2,4-Difluoronitrobenzene has been used in the synthesis of:

  • 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction
  • (±)-horsfiline
  • resin-bound 2-arylaminobenzimidazoles

General Description

Nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine has been investigated using flow reactor with simulated moving bed (SMB) chromatography module.

2,4-Difluoronitrobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Difluoronitrobenzene Suppliers

Shaanxi PharmaGHS Science Co., LTD
Tel
13279368192 13279368192
Email
pharmaghs@126.com
Country
China
ProdList
2889
Advantage
58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
133-96369453 18678026865
Fax
0536-2101172
Email
sdfantai@163.com
Country
China
ProdList
854
Advantage
58
Shandong Xibang Biological Technology Development Co. LTD
Tel
0536-3611186 15063661551
Fax
0536-3611186
Email
196056703@qq.com
Country
China
ProdList
50
Advantage
58
Weifang Weimeng Chemical Co., Ltd.
Tel
0536-8790166 15105445095
Email
weimengchem@163.com
Country
China
ProdList
465
Advantage
58
Weifang Siyuan Chemical Co., Ltd.
Tel
0536-8888106 17663601818
Fax
0536-8888106
Email
2354379876@qq.com
Country
China
ProdList
245
Advantage
58
SHANG FLUORO
Tel
021-65170832 15601903708
Email
qinba_1@163.com
Country
China
ProdList
375
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
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View Lastest Price from 2,4-Difluoronitrobenzene manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
2,4-Difluoronitrobenzene 446-35-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99.%
Supply Ability
10 ton
Release date
2024-08-21
Henan Fengda Chemical Co., Ltd
Product
2,4-Difluoronitrobenzene 446-35-5
Price
US $9.00-0.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-23
Henan Aochuang Chemical Co.,Ltd.
Product
2,4-Difluoronitrobenzene 446-35-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-12

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