2,4-Difluoronitrobenzene

Synthesis

Product Name: 2,4-Difluoronitrobenzene
CAS No.: 446-35-5
Chemical Name: 2,4-Difluoronitrobenzene
Synonyms: 2,4-DIFLUORO-1-NITROBENZENE;2.4 DFNB;2,4-Difluoronitroben;3,5-diflurobenzonitrile;2,4-Difluronitrobenzene;2,4-Difluoronitribenzene;2,4-DIFLUORO NITROBENZEN;2,4-DIFLUORONITROBENZENE;Flurbiprofen Impurity 24;1,3-Difluor-4-nitrobenzol
CBNumber: CB0722917
Molecular Formula: C6H3F2NO2
Formula Weight: 159.09
MOL File: 446-35-5.mol

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2,4-Difluoronitrobenzene Property

Melting point:: 9-10 °C (lit.)
Boiling point:: 203-204 °C (lit.)
Density: 1.451 g/mL at 25 °C (lit.)
vapor density: >1 (vs air)
refractive index: n20/D 1.511(lit.)
Flash point:: 195 °F
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
color: Light yellow to Brown
Specific Gravity: 1.45
Water Solubility: Insoluble in water.
BRN: 2048034
Stability:: Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.
InChI: 1S/C6H3F2NO2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H
InChIKey: RJXOVESYJFXCGI-UHFFFAOYSA-N
SMILES: [O-][N+](=O)c1ccc(F)cc1F
CAS DataBase Reference: 446-35-5(CAS DataBase Reference)
NIST Chemistry Reference: 2,4-Difluoronitrobenzene(446-35-5)
EPA Substance Registry System: 2,4-Difluoronitrobenzene (446-35-5)

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Safety

Hazard Codes: T,Xi,Xn
Risk Statements: 25-36/37/38-23/24/25-20/21/22
Safety Statements: 26-45-36/37/39-23
RIDADR: UN 2810 6.1/PG 1
WGK Germany: 3
RTECS: CZ5730000
Hazard Note: Irritant
TSCA: TSCA listed
HazardClass: 6.1
PackingGroup: III
HS Code: 29049090
Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications: Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 233226
Product name: 2,4-Difluoronitrobenzene
Purity: 99%
Packaging: 25g
Price: $32.87
Updated: 2025/07/31

Sigma-Aldrich

Product number: 233226
Product name: 2,4-Difluoronitrobenzene
Purity: 99%
Packaging: 100g
Price: $120.65
Updated: 2025/07/31

TCI Chemical

Product number: D1636
Product name: 2,4-Difluoronitrobenzene
Purity: >99.0%(GC)
Packaging: 25g
Price: $22
Updated: 2025/07/31

TCI Chemical

Product number: D1636
Product name: 2,4-Difluoronitrobenzene
Purity: >99.0%(GC)
Packaging: 500g
Price: $147
Updated: 2025/07/31

TRC

Product number: D447530
Product name: 2,4-Difluoronitrobenzene
Packaging: 1000g
Price: $745
Updated: 2021/12/16

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2,4-Difluoronitrobenzene Chemical Properties,Usage,Production

Synthesis

KF with n-Hexadecyltrimethylammonium bromide as the PTC has been shown recently to work in dimethylformamide (DMF), important owing to the low cost16 of DMF.

Chemical Properties

yellow liquid

Uses

2,4-Difluoronitrobenzene has been used in the synthesis of: 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction; (±)-horsfiline; resin-bound 2-arylaminobenzimidazoles.
2,?4-?Difluoronitrobenzene is a reactant in the preparation of 4-?thiazolidinone derivatives as antimicrobial agents.

Uses

2,4-Difluoronitrobenzene has been used in the synthesis of 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction, (±)-horsfiline and resin-bound-2-arylaminobenzimidazoles.

Uses

2,4-Difluoronitrobenzene has been used in the synthesis of:

2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction
(±)-horsfiline
resin-bound 2-arylaminobenzimidazoles

General Description

Nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine has been investigated using flow reactor with simulated moving bed (SMB) chromatography module.

References

[1] Catalysis Today, 2012, vol. 198, # 1, p. 300 - 304
[2] Patent: US2009/99387, 2009, A1. Location in patent: Page/Page column 8
[3] Patent: US2009/99387, 2009, A1. Location in patent: Page/Page column 7-9
[4] Tetrahedron, 1995, vol. 51, # 22, p. 6363 - 6376
[5] Journal of the American Chemical Society, 1956, vol. 78, p. 6034,6037

2,4-Difluoronitrobenzene Preparation Products And Raw materials

Raw materials

1,3-Difluorobenzene

Preparation Products

5-Fluoro-2-oxindole 2,4-Difluoroaniline

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2,4-Difluoronitrobenzene Suppliers

Americas 1 Belgium 2 Canada 2 China 382 Europe 5 France 2 Germany 4 India 33 Indonesia 1 Italy 1 Japan 4 Slovakia 1 South Africa 1 South Korea 2 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 19 United States 38 Global 502

Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.

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Shandong Xibang Biological Technology Development Co. LTD

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Alfa Aesar

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View Lastest Price from 2,4-Difluoronitrobenzene manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2,4-Difluoronitrobenzene 446-35-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-07-11

Henan Aochuang Chemical Co.,Ltd.

Product: 2,4-Difluoronitrobenzene 446-35-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-12

Hebei Chuanghai Biotechnology Co,.LTD

Product: 2,4-Difluoronitrobenzene 446-35-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.%
Supply Ability: 10 ton
Release date: 2024-08-21

446-35-5, 2,4-DifluoronitrobenzeneRelated Search:

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1,3-difluoro-4-nitrobenzene

1-Nitro-2,4-difluorobenzene

2,4-difluoro-1-nitro-benzen

2,4-Difluronitrobenzene

Benzene, 2,4-difluoro-1-nitro-

2,4-DIFLUORO-1-NITROBENZENE

2,4-DIFLUORONITROBENZENE

2,4-DIFLUORO NITROBENZEN

2,4-Difluoronitribenzene

Benzene, 2,4-difluoro-1-nitro- (6CI,7CI,8CI,9CI)

3,5-diflurobenzonitrile

2,4-DIFLUORONITROBENZENE =99%(HPLC)

2,4-Difluoronitroben

2.4 DFNB

2,4-Difluoronitrobenzene14

2, 4-2 fluoro nitrobenzene

2,4-Difluoronitrobenzene99%

1,3-Difluor-4-nitrobenzol

2,4-Difluoronitrobenzene&gt

2,4-Difluoronitrobenzene,>98%

Flurbiprofen Impurity 24

2,4-Difluoronitrobenzene ISO 9001：2015 REACH

4-flouro-3-nitrobenzene sulfonic acid potassium salt

high quality 2,4-Difluoronitrobenzene

2,4-Difluoronitrobenzene extrapure, 99%

2,4- Di Fluoro Nitro Benzene (2,4 DFNB)

2,4-Difluoro-1-nitrobenzene, 98%

446-35-5

F2C6H3NO2

Building Blocks

Nitro Compounds

Organic Building Blocks

Nitrogen Compounds

Fluorine series

alkyl Fluorine| nitro-compound

HALIDE

Aromatic Hydrocarbons (substituted) & Derivatives