2,4-Difluoronitrobenzene
Synthesis- Product Name
- 2,4-Difluoronitrobenzene
- CAS No.
- 446-35-5
- Chemical Name
- 2,4-Difluoronitrobenzene
- Synonyms
- 2,4-DIFLUORO-1-NITROBENZENE;2.4 DFNB;2,4-Difluoronitroben;3,5-diflurobenzonitrile;2,4-Difluronitrobenzene;2,4-Difluoronitribenzene;2,4-DIFLUORO NITROBENZEN;2,4-DIFLUORONITROBENZENE;Flurbiprofen Impurity 24;1,3-Difluor-4-nitrobenzol
- CBNumber
- CB0722917
- Molecular Formula
- C6H3F2NO2
- Formula Weight
- 159.09
- MOL File
- 446-35-5.mol
2,4-Difluoronitrobenzene Property
- Melting point:
- 9-10 °C (lit.)
- Boiling point:
- 203-204 °C (lit.)
- Density
- 1.451 g/mL at 25 °C (lit.)
- vapor density
- >1 (vs air)
- refractive index
- n20/D 1.511(lit.)
- Flash point:
- 195 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Light yellow to Brown
- Specific Gravity
- 1.45
- Water Solubility
- Insoluble in water.
- BRN
- 2048034
- Stability:
- Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.
- InChIKey
- RJXOVESYJFXCGI-UHFFFAOYSA-N
- CAS DataBase Reference
- 446-35-5(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,4-Difluoronitrobenzene(446-35-5)
- EPA Substance Registry System
- 2,4-Difluoronitrobenzene (446-35-5)
Safety
- Hazard Codes
- T,Xi,Xn
- Risk Statements
- 25-36/37/38-23/24/25-20/21/22
- Safety Statements
- 26-45-36/37/39-23
- RIDADR
- UN 2810 6.1/PG 1
- WGK Germany
- 3
- RTECS
- CZ5730000
- Hazard Note
- Irritant
- TSCA
- T
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29049090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 233226
- Product name
- 2,4-Difluoronitrobenzene
- Purity
- 99%
- Packaging
- 25g
- Price
- $32.87
- Updated
- 2025/07/31
- Product number
- 233226
- Product name
- 2,4-Difluoronitrobenzene
- Purity
- 99%
- Packaging
- 100g
- Price
- $120.65
- Updated
- 2025/07/31
- Product number
- D1636
- Product name
- 2,4-Difluoronitrobenzene
- Purity
- >99.0%(GC)
- Packaging
- 25g
- Price
- $22
- Updated
- 2025/07/31
- Product number
- D1636
- Product name
- 2,4-Difluoronitrobenzene
- Purity
- >99.0%(GC)
- Packaging
- 500g
- Price
- $147
- Updated
- 2025/07/31
- Product number
- D447530
- Product name
- 2,4-Difluoronitrobenzene
- Packaging
- 1000g
- Price
- $745
- Updated
- 2021/12/16
2,4-Difluoronitrobenzene Chemical Properties,Usage,Production
Synthesis
KF with n-Hexadecyltrimethylammonium bromide as the PTC has been shown
recently to work in dimethylformamide (DMF), important owing to the low cost16 of
DMF.
Chemical Properties
yellow liquid
Uses
2,4-Difluoronitrobenzene has been used in the synthesis of:
2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction;
(±)-horsfiline;
resin-bound 2-arylaminobenzimidazoles.
2,?4-?Difluoronitrobenzene is a reactant in the preparation of 4-?thiazolidinone derivatives as antimicrobial agents.
Uses
2,4-Difluoronitrobenzene has been used in the synthesis of 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction, (±)-horsfiline and resin-bound-2-arylaminobenzimidazoles.
Uses
2,4-Difluoronitrobenzene has been used in the synthesis of:
- 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction
- (±)-horsfiline
- resin-bound 2-arylaminobenzimidazoles
General Description
Nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine has been investigated using flow reactor with simulated moving bed (SMB) chromatography module.
References
[1] Catalysis Today, 2012, vol. 198, # 1, p. 300 - 304
[2] Patent: US2009/99387, 2009, A1. Location in patent: Page/Page column 8
[3] Patent: US2009/99387, 2009, A1. Location in patent: Page/Page column 7-9
[4] Tetrahedron, 1995, vol. 51, # 22, p. 6363 - 6376
[5] Journal of the American Chemical Society, 1956, vol. 78, p. 6034,6037
2,4-Difluoronitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Difluoronitrobenzene manufacturers
- Product
- 2,4-Difluoronitrobenzene 446-35-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-07-11
- Product
- 2,4-Difluoronitrobenzene 446-35-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-12
- Product
- 2,4-Difluoronitrobenzene 446-35-5
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.%
- Supply Ability
- 10 ton
- Release date
- 2024-08-21