5-Fluoro-2-oxindole
- Product Name
- 5-Fluoro-2-oxindole
- CAS No.
- 56341-41-4
- Chemical Name
- 5-Fluoro-2-oxindole
- Synonyms
- 5-Fluoro-1,3-dihydro-indol-2-one;5-FLUORO-2-OXYINDOLE;5-FLUOROOXINDOLE;uorooxindoL;Fluorooxindole;5-FLUROOXINDOLE;5-Fluorooxindole98%;5-FLUORO-2-OXINDOLE;5-Fluorooxindole>5-Fluor0-2-oxindole
- CBNumber
- CB3437333
- Molecular Formula
- C8H6FNO
- Formula Weight
- 151.14
- MOL File
- 56341-41-4.mol
5-Fluoro-2-oxindole Property
- Melting point:
- 143-147 °C (lit.)
- Boiling point:
- 307.2±42.0 °C(Predicted)
- Density
- 1.311±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 12.99±0.20(Predicted)
- form
- Powder or Crystalline Powder
- color
- White to pale brown
- InChI
- InChI=1S/C8H6FNO/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4H2,(H,10,11)
- InChIKey
- DDIIYGHHUMKDGI-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(F)C=C2)CC1=O
- CAS DataBase Reference
- 56341-41-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,C
- Risk Statements
- 36/37/38-34
- Safety Statements
- 22-24/25-45-36/37/39-27-26
- WGK Germany
- 3
- Hazard Note
- Irritant/Keep Cold
- HazardClass
- IRRITANT, KEEP COLD
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 586579
- Product name
- 5-Fluoro-2-oxindole
- Purity
- 97%
- Packaging
- 500mg
- Price
- $133
- Updated
- 2023/06/20
- Product number
- F0699
- Product name
- 5-Fluorooxindole
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $65
- Updated
- 2024/03/01
- Product number
- F0699
- Product name
- 5-Fluorooxindole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $208
- Updated
- 2024/03/01
- Product number
- H32176
- Product name
- 5-Fluorooxindole, 97%
- Packaging
- 1g
- Price
- $82.65
- Updated
- 2024/03/01
- Product number
- F595140
- Product name
- 5-Fluoro-2-oxindole
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
5-Fluoro-2-oxindole Chemical Properties,Usage,Production
Chemical Properties
Light Yellow Crystalline
Uses
5-Fluoro-2-oxindole (cas# 56341-41-4) is a compound useful in organic synthesis.
Application
5-Fluoro-2-oxindole is a ketone organic compound that can be used as an intermediate in the preparation of sunitinib. Sunitinib is a novel multi-targeted oral drug for the treatment of tumors.
Preparation
synthesis of 5-fluoro-2-oxindole: 4-fluoroaniline was used as the starting material, reacted with chloral hydrate and hydroxylamine hydrochloride to generate 4-fluoroisonitrosoacetanilide, and then cyclized under the action of concentrated sulfuric acid to form the compound 5-fluoroisatin was finally obtained by wolff-kishner-huang minlon reduction to obtain 5-fluoro-2-oxindole with a total yield of 66%.
Biological Activity
5-Fluoro-2-oxindole has anti-inflammatory, antioxidant, anxiolytic, antidepressant and antinociceptive effects and inhibits neuropathic pain. Treatment with 5-Fluoro-2-oxindole increased the expression of NQO1, HO-1, and MOR in the spinal cord and/or paw and inhibited CFA-induced up-regulation of phosphorylated MAPK, 4-HNE, NOS2, CD11b/c, and IBA-1. 5-Fluoro-2-oxindole ameliorated the local effects of morphine. Studies have revealed that 5-fluoro-2-oxindole inhibits plasticity, oxidative and inflammatory responses induced by peripheral inflammation and enhances the antinociceptive effects of morphine. Thus, the use of 5-fluoro-2-indole alone and/or in combination with morphine are two remarkable new approaches for the treatment of chronic inflammatory pain.
5-Fluoro-2-oxindole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Fluoro-2-oxindole manufacturers
- Product
- 5-Fluoro-2-oxindole 56341-41-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-20
- Product
- 5-Fluoro-2-oxindole 56341-41-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 98
- Supply Ability
- 1KG
- Release date
- 2024-11-21
- Product
- 5-Fluoro-2-oxindole 56341-41-4
- Price
- US $0.00/G
- Min. Order
- 100G
- Purity
- 98%min
- Supply Ability
- 30kg/month
- Release date
- 2023-02-07