ChemicalBook > CAS DataBase List > 5-Fluoro-2-oxindole

5-Fluoro-2-oxindole

Product Name
5-Fluoro-2-oxindole
CAS No.
56341-41-4
Chemical Name
5-Fluoro-2-oxindole
Synonyms
5-Fluoro-1,3-dihydro-indol-2-one;5-FLUORO-2-OXYINDOLE;5-FLUOROOXINDOLE;uorooxindoL;Fluorooxindole;5-FLUROOXINDOLE;5-Fluorooxindole98%;5-FLUORO-2-OXINDOLE;5-Fluorooxindole>5-Fluor0-2-oxindole
CBNumber
CB3437333
Molecular Formula
C8H6FNO
Formula Weight
151.14
MOL File
56341-41-4.mol
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5-Fluoro-2-oxindole Property

Melting point:
143-147 °C (lit.)
Boiling point:
307.2±42.0 °C(Predicted)
Density 
1.311±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
12.99±0.20(Predicted)
form 
Powder or Crystalline Powder
color 
White to pale brown
InChI
InChI=1S/C8H6FNO/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4H2,(H,10,11)
InChIKey
DDIIYGHHUMKDGI-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(F)C=C2)CC1=O
CAS DataBase Reference
56341-41-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,C
Risk Statements 
36/37/38-34
Safety Statements 
22-24/25-45-36/37/39-27-26
WGK Germany 
3
Hazard Note 
Irritant/Keep Cold
HazardClass 
IRRITANT, KEEP COLD
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
586579
Product name
5-Fluoro-2-oxindole
Purity
97%
Packaging
500mg
Price
$133
Updated
2023/06/20
TCI Chemical
Product number
F0699
Product name
5-Fluorooxindole
Purity
>98.0%(GC)
Packaging
1g
Price
$65
Updated
2024/03/01
TCI Chemical
Product number
F0699
Product name
5-Fluorooxindole
Purity
>98.0%(GC)
Packaging
5g
Price
$208
Updated
2024/03/01
Alfa Aesar
Product number
H32176
Product name
5-Fluorooxindole, 97%
Packaging
1g
Price
$82.65
Updated
2024/03/01
TRC
Product number
F595140
Product name
5-Fluoro-2-oxindole
Packaging
500mg
Price
$50
Updated
2021/12/16
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5-Fluoro-2-oxindole Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Crystalline

Uses

5-Fluoro-2-oxindole (cas# 56341-41-4) is a compound useful in organic synthesis.

Application

5-Fluoro-2-oxindole is a ketone organic compound that can be used as an intermediate in the preparation of sunitinib. Sunitinib is a novel multi-targeted oral drug for the treatment of tumors.

Preparation

synthesis of 5-fluoro-2-oxindole: 4-fluoroaniline was used as the starting material, reacted with chloral hydrate and hydroxylamine hydrochloride to generate 4-fluoroisonitrosoacetanilide, and then cyclized under the action of concentrated sulfuric acid to form the compound 5-fluoroisatin was finally obtained by wolff-kishner-huang minlon reduction to obtain 5-fluoro-2-oxindole with a total yield of 66%.

Biological Activity

5-Fluoro-2-oxindole has anti-inflammatory, antioxidant, anxiolytic, antidepressant and antinociceptive effects and inhibits neuropathic pain. Treatment with 5-Fluoro-2-oxindole increased the expression of NQO1, HO-1, and MOR in the spinal cord and/or paw and inhibited CFA-induced up-regulation of phosphorylated MAPK, 4-HNE, NOS2, CD11b/c, and IBA-1. 5-Fluoro-2-oxindole ameliorated the local effects of morphine. Studies have revealed that 5-fluoro-2-oxindole inhibits plasticity, oxidative and inflammatory responses induced by peripheral inflammation and enhances the antinociceptive effects of morphine. Thus, the use of 5-fluoro-2-indole alone and/or in combination with morphine are two remarkable new approaches for the treatment of chronic inflammatory pain.

5-Fluoro-2-oxindole Preparation Products And Raw materials

Raw materials

2,4-Difluoronitrobenzene Sodium hydride Dimethyl malonate Dimethyl sulfoxide Iron Lithium chloride

Preparation Products

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5-Fluoro-2-oxindole Suppliers

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View Lastest Price from 5-Fluoro-2-oxindole manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
5-Fluoro-2-oxindole 56341-41-4
Price
US $0.00/G
Min. Order
100G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-07
Nanjing Fred Technology Co., Ltd
Product
5-Fluoro-2-oxindole 56341-41-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-20
Hebei Weibang Biotechnology Co., Ltd
Product
5-Fluoro-2-oxindole 56341-41-4
Price
US $10.00/KG
Min. Order
1KG
Purity
98
Supply Ability
1KG
Release date
2024-11-21

56341-41-4, 5-Fluoro-2-oxindoleRelated Search:

Naringin dihydrochalcone Oxindole 4-Fluoroacetophenone 5-Fluoroindole Indole-3-butyric acid Fluorochloridone 4'-(Trifluoromethyl)acetophenone Indole-3-acetic acid cis-Octahydroisoindole Fluridone 1-(2,6-Dichlorophenyl)indolin-2-one Isophorone Dehydroepiandrosterone Indometacin 7-FLUORO-2-OXINDOLE 3-Amino-5-fluoropyridine Sunitinib N-Oxide Sunitinib Impurity B

  • 5-Fluoroindole-2-One
  • 5-Fluoro-1,3-dihydro-indol-2-one
  • 5-FLUORO-2-OXINDOLE
  • 5-FLUORO-2-OXYINDOLE
  • 5-FLUORO-1,3-DIHYDRO-2H-INDOL-2-ONE
  • 5-Fluorooxindole 98%
  • 5-Fluorooxindole98%
  • 5-FLUROOXINDOLE
  • 5-Flouro-1,3-dihydro-indole-2-one
  • Sunitinib Impurity 49
  • 2H-Indol-2-one,5-fluoro-1,3-dihydro-(9CI)
  • 5-FLUORO-2-OXINDOLE, 98+%
  • 5-FLUORO-2-NITROPHENYLACETATE
  • 5-Fluoro-2-indolinone
  • 2H-Indol-2-one, 5-fluoro-1,3-dihydro-
  • 5-FLUOROOXINDOLE
  • Fluorooxindole
  • 5-Fluoro-2-oxindole 98%
  • 1H-indol-5-yl hypofluorite
  • 1,3-Dihydro-5-fluoro-2H-indol-2-one, 5-Fluoroindolin-2-one
  • 5-Fluoro-2-oxindole 5-Fluorooxindole
  • 5-Fluoro-2,3-dihydro-2-oxoindole
  • 5‐fluoro‐2,3‐dihydro‐1H‐indol‐2‐one
  • 5-FLUORO-2-OXINDOLE (RETURNED FOR RE-EXP
  • Sunitinib Impurity 26
  • 5-Fluoro-2-oxindole in stock Factory
  • 5-Fluorooxindole (5-Fluoro-1,3-dihy
  • 5-Fluorooxindole&gt
  • uorooxindoL
  • 5-Fluor0-2-oxindole
  • 5-Fluoro-2-oxindole ISO 9001：2015 REACH
  • 5-Fluorooxindole (5-Fluoro-1,3-dihydro-2H-indol-2-one)
  • 5-Fluoro-2-oxoindoline
  • 5-flouro-1,3-dihydroindol-2-one,5-flouro-2,3-dihydro-2-oxoindole
  • 56341-41-4
  • 5634-41-4
  • 56341-41-1
  • 5641-41-1
  • 56341-41-1
  • Heterocyclic Building Blocks
  • Indoles
  • Building Blocks
  • Fluorinated heterocyclic series
  • Indoles and derivatives
  • Indole/indoline/oxindole
  • Indole and Indoline
  • Heterocycles
  • Aromatics Compounds
  • Halides
  • Pyrroles & Indoles
  • ketone
  • Sunitinib
  • Aromatics
  • Intermediate of sunitinib malate
  • Pyrroles & Indoles
  • Boronic Acid
  • Heterocyclic Compounds
  • Building Blocks