7-Fluorooxindole
- Product Name
- 7-Fluorooxindole
- CAS No.
- 71294-03-6
- Chemical Name
- 7-Fluorooxindole
- Synonyms
- 7-FLUOROINDOLIN-2-ONE;2H-Indol-2-one;7-FLUOROOXINDOLE;7-Fluorooxindole97%;7-FLUORO-2-OXINDOLE;7-Fluorooxindole 97%;7-Fluoro-2-oxyindole;7-FLUOROINDOLE-2-ONE;Sunitinib Impurity 59;7-Fluoro-2-oxindole 97%
- CBNumber
- CB6397166
- Molecular Formula
- C8H6FNO
- Formula Weight
- 151.14
- MOL File
- 71294-03-6.mol
7-Fluorooxindole Property
- Melting point:
- 188-190°C
- Boiling point:
- 297.9±40.0 °C(Predicted)
- Density
- 1.311±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- Powder
- pka
- 12.93±0.20(Predicted)
- color
- Red-brown
- InChI
- InChI=1S/C8H6FNO/c9-6-3-1-2-5-4-7(11)10-8(5)6/h1-3H,4H2,(H,10,11)
- InChIKey
- VMUIOEOYZHJLEZ-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2F)CC1=O
- LogP
- 0.7 at 25℃ and pH6.8
- CAS DataBase Reference
- 71294-03-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,C,Xn
- Risk Statements
- 36/37/38-34-22
- Safety Statements
- 26-36/37/39-45-27
- Hazard Note
- Irritant/Keep Cold
- HS Code
- 2933790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F595018
- Product name
- 7-Fluorooxindole
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- F595018
- Product name
- 7-Fluorooxindole
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- PC1738
- Product name
- 7-Fluoro-2-oxindole
- Purity
- 98%
- Packaging
- 250mg
- Price
- $18
- Updated
- 2021/12/16
- Product number
- 4H48-3-07
- Product name
- 7-Fluorooxindole
- Purity
- 98%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- PC1738
- Product name
- 7-Fluoro-2-oxindole
- Purity
- 98%
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
7-Fluorooxindole Chemical Properties,Usage,Production
Synthesis
872141-25-8
71294-03-6
The general procedure for the synthesis of 7-fluoro-2-indolone from 2-(3-fluoro-2-nitrophenyl)acetic acid was as follows: 2-(3-fluoro-2-nitrophenyl)acetic acid (9.6 g, 48 mmol) was dissolved in acetic acid (100 mL), 10% palladium-carbon catalyst (1.3 g) was added, and the hydrogenation reaction was carried out for 24 h at 50 psi hydrogen pressure. Upon completion of the reaction, the catalyst was filtered through Celite to remove the catalyst. Subsequently, the solvent in the reaction solution was removed by evaporation. The resulting residue was dissolved in ethanol (100 mL), p-toluenesulfonic acid (50 mg) was added, and the mixture was heated to reflux for 1 hour. The reaction solution was cooled, poured into water and extracted with ethyl acetate, the organic phase was dried with anhydrous magnesium sulfate and the solvent was evaporated. Finally, the solid obtained was ground with hexane/ethyl acetate (95/5, v/v) mixed solvent to give 7-fluoro-1,3-dihydro-indol-2-one (6 g, 83% yield).
References
[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1861 - 1873
[2] Patent: US2006/9509, 2006, A1. Location in patent: Page/Page column 9
7-Fluorooxindole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-Fluorooxindole manufacturers
- Product
- 7-Fluorooxindole 71294-03-6
- Price
- US $36.00-1.50/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 7-Fluorooxindole 71294-03-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 7-Fluorooxindole 71294-03-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09