ChemicalBook > CAS DataBase List > 7-Fluorooxindole

7-Fluorooxindole

Product Name
7-Fluorooxindole
CAS No.
71294-03-6
Chemical Name
7-Fluorooxindole
Synonyms
7-FLUOROINDOLIN-2-ONE;2H-Indol-2-one;7-FLUOROOXINDOLE;7-Fluorooxindole97%;7-FLUORO-2-OXINDOLE;7-Fluorooxindole 97%;7-Fluoro-2-oxyindole;7-FLUOROINDOLE-2-ONE;Sunitinib Impurity 59;7-Fluoro-2-oxindole 97%
CBNumber
CB6397166
Molecular Formula
C8H6FNO
Formula Weight
151.14
MOL File
71294-03-6.mol
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7-Fluorooxindole Property

Melting point:
188-190°C
Boiling point:
297.9±40.0 °C(Predicted)
Density 
1.311±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
Powder
pka
12.93±0.20(Predicted)
color 
Red-brown
InChI
InChI=1S/C8H6FNO/c9-6-3-1-2-5-4-7(11)10-8(5)6/h1-3H,4H2,(H,10,11)
InChIKey
VMUIOEOYZHJLEZ-UHFFFAOYSA-N
SMILES
N1C2=C(C=CC=C2F)CC1=O
LogP
0.7 at 25℃ and pH6.8
CAS DataBase Reference
71294-03-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,C,Xn
Risk Statements 
36/37/38-34-22
Safety Statements 
26-36/37/39-45-27
Hazard Note 
Irritant/Keep Cold
HS Code 
2933790090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
F595018
Product name
7-Fluorooxindole
Packaging
250mg
Price
$55
Updated
2021/12/16
TRC
Product number
F595018
Product name
7-Fluorooxindole
Packaging
1g
Price
$75
Updated
2021/12/16
AK Scientific
Product number
X0306
Product name
7-Fluorooxindole
Packaging
250mg
Price
$77
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0025396
Product name
7-FLUOROOXINDOLE
Purity
95.00%
Packaging
250MG
Price
$658.35
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0025396
Product name
7-FLUOROOXINDOLE
Purity
95.00%
Packaging
1G
Price
$739.2
Updated
2021/12/16
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7-Fluorooxindole Chemical Properties,Usage,Production

Synthesis

872141-25-8

71294-03-6

The general procedure for the synthesis of 7-fluoro-2-indolone from 2-(3-fluoro-2-nitrophenyl)acetic acid was as follows: 2-(3-fluoro-2-nitrophenyl)acetic acid (9.6 g, 48 mmol) was dissolved in acetic acid (100 mL), 10% palladium-carbon catalyst (1.3 g) was added, and the hydrogenation reaction was carried out for 24 h at 50 psi hydrogen pressure. Upon completion of the reaction, the catalyst was filtered through Celite to remove the catalyst. Subsequently, the solvent in the reaction solution was removed by evaporation. The resulting residue was dissolved in ethanol (100 mL), p-toluenesulfonic acid (50 mg) was added, and the mixture was heated to reflux for 1 hour. The reaction solution was cooled, poured into water and extracted with ethyl acetate, the organic phase was dried with anhydrous magnesium sulfate and the solvent was evaporated. Finally, the solid obtained was ground with hexane/ethyl acetate (95/5, v/v) mixed solvent to give 7-fluoro-1,3-dihydro-indol-2-one (6 g, 83% yield).

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1861 - 1873
[2] Patent: US2006/9509, 2006, A1. Location in patent: Page/Page column 9

7-Fluorooxindole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7-Fluorooxindole manufacturers

Henan Fengda Chemical Co., Ltd
Product
7-Fluorooxindole 71294-03-6
Price
US $36.00-1.50/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
7-Fluorooxindole 71294-03-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
7-Fluorooxindole 71294-03-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

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