7-Aminoindole
- Product Name
- 7-Aminoindole
- CAS No.
- 5192-04-1
- Chemical Name
- 7-Aminoindole
- Synonyms
- 103706;7-Indolamine;7-AMINOINDOLE;7-Indolylamine;1H-Indol-7-amine;(Indol-7-yl)amine;7-Amino-1H-indole;1H-INDOL-7-YLAMINE;7-Aminoindole, 97%,;7-Amino-1H-indole 97%
- CBNumber
- CB5270978
- Molecular Formula
- C8H8N2
- Formula Weight
- 132.16
- MOL File
- 5192-04-1.mol
7-Aminoindole Property
- Melting point:
- 96-100 °C
- Boiling point:
- 354.0±15.0 °C(Predicted)
- Density
- 1.268±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 17.68±0.30(Predicted)
- color
- Black
- Sensitive
- Air Sensitive
- BRN
- 471787
- InChI
- 1S/C8H8N2/c9-7-3-1-2-6-4-5-10-8(6)7/h1-5,10H,9H2
- InChIKey
- WTFWZOSMUGZKNZ-UHFFFAOYSA-N
- SMILES
- Nc1cccc2cc[nH]c12
- CAS DataBase Reference
- 5192-04-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A3517
- Product name
- 1H-Indol-7-amine
- Purity
- min. 98.0 %
- Packaging
- 200MG
- Price
- $126
- Updated
- 2026/03/19
- Product number
- A3517
- Product name
- 1H-Indol-7-amine
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $377
- Updated
- 2026/03/19
- Product number
- A612670
- Product name
- 7-Aminoindole
- Packaging
- 500mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- A612670
- Product name
- 7-Aminoindole
- Packaging
- 1g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 3H30-1-B0
- Product name
- 7-Amino-1H-indole
- Purity
- 97.0%
- Packaging
- 500mg
- Price
- $128
- Updated
- 2021/12/16
7-Aminoindole Chemical Properties,Usage,Production
Uses
Reactant for preparation of:• ;Fluorescent anion receptors and sensors1,2• ;Sulfate receptors3• ;Protein Kinase C θ (PKCθ) inhibitors4• ;Factor Xa Inhibitors5• ;Aurora kinase inhibitor• ;Antagonist of Mineralocorticoid Receptor6• ;Potent histone deacetylase (HDAC) inhibitors7• ;TRPV1 antagonists8• ;Derivatives of N-(7-indolyl)benzenesulfonamide as cell cycle inhibitors9
Uses
Reactant for preparation of:
- Fluorescent anion receptors and sensors
- Sulfate receptors
- Protein Kinase C θ (PKCθ) inhibitors
- Factor Xa Inhibitors
- Aurora kinase inhibitor
- Antagonist of Mineralocorticoid Receptor
- Potent histone deacetylase (HDAC) inhibitors
- TRPV1 antagonists
- Derivatives of N-(7-indolyl)benzenesulfonamide as cell cycle inhibitors
Definition
ChEBI: 1H-indol-7-amine is an indolamine.
Synthesis
6960-42-5
5192-04-1
The general procedure for the synthesis of 7-aminoindoles using 7-nitroindoles as starting material is as follows: 7-nitroindoles were dissolved in ethanol according to the method described in Scheme VII (step A). To this solution was added ammonium formate (10 equivalents) and a catalytic amount of 10% palladium carbon. Subsequently, the reaction mixture was heated to reflux for 1 hour. Upon completion of the reaction, it was cooled to room temperature, filtered through a diatomaceous earth pad to remove the catalyst, and the filtrate was concentrated under reduced pressure to give 7-aminoindole in purple solid form in 99% yield.
References
[1] Patent: WO2004/67529, 2004, A1. Location in patent: Page 75 - 76
[2] Patent: WO2005/92854, 2005, A1. Location in patent: Page/Page column 53
[3] Green Chemistry, 2017, vol. 19, # 3, p. 809 - 815
[4] Synthetic Communications, 2018, vol. 48, # 19, p. 2475 - 2484
[5] Patent: WO2005/92854, 2005, A1. Location in patent: Page/Page column 56-57
7-Aminoindole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-Aminoindole manufacturers
- Product
- 7-Aminoindole in stock Factory 5192-04-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- TOP 3 Factory in China
- Supply Ability
- Top 3 largest production capacity Factory
- Release date
- 2019-04-03