ChemicalBook > CAS DataBase List > 7-Aminoindole

7-Aminoindole

Product Name
7-Aminoindole
CAS No.
5192-04-1
Chemical Name
7-Aminoindole
Synonyms
103706;7-Indolamine;7-AMINOINDOLE;7-Indolylamine;1H-Indol-7-amine;(Indol-7-yl)amine;7-Amino-1H-indole;1H-INDOL-7-YLAMINE;7-Aminoindole, 97%,;7-Amino-1H-indole 97%
CBNumber
CB5270978
Molecular Formula
C8H8N2
Formula Weight
132.16
MOL File
5192-04-1.mol
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7-Aminoindole Property

Melting point:
96-100 °C
Boiling point:
354.0±15.0 °C(Predicted)
Density 
1.268±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
17.68±0.30(Predicted)
color 
Black
Sensitive 
Air Sensitive
BRN 
471787
CAS DataBase Reference
5192-04-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
10-23
Hazard Note 
Harmful/Irritant/Keep Cold
PackingGroup 
III
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A3517
Product name
1H-Indol-7-amine
Purity
min. 98.0 %
Packaging
200MG
Price
$157
Updated
2025/07/31
TCI Chemical
Product number
A3517
Product name
1H-Indol-7-amine
Purity
min. 98.0 %
Packaging
1G
Price
$471
Updated
2025/07/31
TRC
Product number
A612670
Product name
7-Aminoindole
Packaging
500mg
Price
$85
Updated
2021/12/16
TRC
Product number
A612670
Product name
7-Aminoindole
Packaging
1g
Price
$115
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-1-B0
Product name
7-Amino-1H-indole
Purity
97.0%
Packaging
500mg
Price
$128
Updated
2021/12/16
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7-Aminoindole Chemical Properties,Usage,Production

Uses

Reactant for preparation of:• ;Fluorescent anion receptors and sensors1,2• ;Sulfate receptors3• ;Protein Kinase C θ (PKCθ) inhibitors4• ;Factor Xa Inhibitors5• ;Aurora kinase inhibitor• ;Antagonist of Mineralocorticoid Receptor6• ;Potent histone deacetylase (HDAC) inhibitors7• ;TRPV1 antagonists8• ;Derivatives of N-(7-indolyl)benzenesulfonamide as cell cycle inhibitors9

Uses

Reactant for preparation of:

  • Fluorescent anion receptors and sensors
  • Sulfate receptors
  • Protein Kinase C θ (PKCθ) inhibitors
  • Factor Xa Inhibitors
  • Aurora kinase inhibitor
  • Antagonist of Mineralocorticoid Receptor
  • Potent histone deacetylase (HDAC) inhibitors
  • TRPV1 antagonists
  • Derivatives of N-(7-indolyl)benzenesulfonamide as cell cycle inhibitors

Definition

ChEBI: 1H-indol-7-amine is an indolamine.

Synthesis

6960-42-5

5192-04-1

The general procedure for the synthesis of 7-aminoindoles using 7-nitroindoles as starting material is as follows: 7-nitroindoles were dissolved in ethanol according to the method described in Scheme VII (step A). To this solution was added ammonium formate (10 equivalents) and a catalytic amount of 10% palladium carbon. Subsequently, the reaction mixture was heated to reflux for 1 hour. Upon completion of the reaction, it was cooled to room temperature, filtered through a diatomaceous earth pad to remove the catalyst, and the filtrate was concentrated under reduced pressure to give 7-aminoindole in purple solid form in 99% yield.

References

[1] Patent: WO2004/67529, 2004, A1. Location in patent: Page 75 - 76
[2] Patent: WO2005/92854, 2005, A1. Location in patent: Page/Page column 53
[3] Green Chemistry, 2017, vol. 19, # 3, p. 809 - 815
[4] Synthetic Communications, 2018, vol. 48, # 19, p. 2475 - 2484
[5] Patent: WO2005/92854, 2005, A1. Location in patent: Page/Page column 56-57

7-Aminoindole Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Aminoindole Suppliers

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View Lastest Price from 7-Aminoindole manufacturers

Chemwill Asia Co.,Ltd.
Product
7-Aminoindole in stock Factory 5192-04-1
Price
US $1.00/KG
Min. Order
1KG
Purity
TOP 3 Factory in China
Supply Ability
Top 3 largest production capacity Factory
Release date
2019-04-03

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  • 7-AMinoindole, >=95.0% (HPLC)
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  • 7-Indolamine
  • 7-Amino-1H-indole
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  • (Indol-7-yl)amine
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  • 1H-indol-7-amine - [K15817]
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