Synthesis
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4'-(Trifluoromethyl)acetophenone

Synthesis
Product Name
4'-(Trifluoromethyl)acetophenone
CAS No.
709-63-7
Chemical Name
4'-(Trifluoromethyl)acetophenone
Synonyms
4-(TRIFLUOROMETHYL)ACETOPHENONE;1-(4-Trifluoromethyl-phenyl)-ethanone;NSC 88346;4-Acetylbe;4-ACETYLBENZOFLUORIDE;On the trifluoroMethyl;4-ACETYLBENZOTRIFLUORIDE;P-TRIFLUOROMETHYLACETOPHENONE;4-(trifluromethyl)acetophenone;4-TRIFLUOROMETHYL BENZYLDEHYDE
CBNumber
CB9717518
Molecular Formula
C9H7F3O
Formula Weight
188.15
MOL File
709-63-7.mol
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4'-(Trifluoromethyl)acetophenone Property

Melting point:
30-33 °C(lit.)
Boiling point:
79-80 °C8 mm Hg(lit.)
Density 
0.92
refractive index 
1.4604
Flash point:
184 °F
storage temp. 
Sealed in dry,Room Temperature
form 
Low Melting Solid
color 
White to faintly yellow
BRN 
1870425
CAS DataBase Reference
709-63-7(CAS DataBase Reference)
NIST Chemistry Reference
4-CF3-C6H4-COCH3(709-63-7)
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Safety

Hazard Codes 
Xi,F
Risk Statements 
36/37/38-11
Safety Statements 
26-36-37/39-16
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29147090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
233188
Product name
4′-(Trifluoromethyl)acetophenone
Purity
98%
Packaging
25g
Price
$112.2
Updated
2024/03/01
Sigma-Aldrich
Product number
233188
Product name
4′-(Trifluoromethyl)acetophenone
Purity
98%
Packaging
5g
Price
$120
Updated
2024/03/01
TCI Chemical
Product number
T1784
Product name
4'-(Trifluoromethyl)acetophenone
Purity
>98.0%(GC)
Packaging
1g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
T1784
Product name
4'-(Trifluoromethyl)acetophenone
Purity
>98.0%(GC)
Packaging
5g
Price
$41
Updated
2024/03/01
Alfa Aesar
Product number
A15529
Product name
4'-(Trifluoromethyl)acetophenone, 98+%
Packaging
5g
Price
$93.65
Updated
2024/03/01
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4'-(Trifluoromethyl)acetophenone Chemical Properties,Usage,Production

Synthesis

41.6 g of chlorocyclohexane (0.35 mol) were added dropwise to a suspension of 4.65 g of lithium particles (0.68 mol) in 350 g of THF at -55 °C, and an addition time of 2 hours was chosen. After >97% chlorocyclohexane conversion by GC (10 hours), a mixture of 38.3 g of 4-bromotrifluorotoluene (0.170 mol) and 7.0 g of acetonitrile (0.170 mol) was added dropwise at the same temperature for 15 minutes. After stirring for an additional 30 minutes at -50°C, the reaction mixture was slowly thawed to room temperature and subjected to an aqueous workup in a conventional manner. The yield of 4-trifluoromethylacetophenone after distillation was 81%.

Chemical Properties

White to faintly yellow low melting solid

Uses

A labelled acetophenone with selective antimycobacterial activity.

General Description

The enantioselective addition of dialkylzinc to 4′-(trifluoromethyl)acetophenone mediated by 1,2-bis(hydroxycamphorsulfonamido)cyclohexenes in the presence of titanium tetraisopropoxide has been investigated. Phosphorescence emission spectra of 4′-(trifluoromethyl)acetophenone has been studied using pulsed source phosphorimetry.

Purification Methods

Purify the ketone by distillation or sublimation in vacuo.[Beilstein 7 IV 1404.]

4'-(Trifluoromethyl)acetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-(Trifluoromethyl)acetophenone Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Beijing Mediking Biopharm Co., Ltd
Tel
010-81769521,89753524,81760121 15901403431
Fax
+86-10-81769652
Email
sales01@mediking.cn
Country
China
ProdList
704
Advantage
68
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12438
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
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View Lastest Price from 4'-(Trifluoromethyl)acetophenone manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4'-(Trifluoromethyl)acetophenone 709-63-7
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%
Supply Ability
2000tons
Release date
2020-01-16
Shanghai Rlavie Technology Co ltd
Product
4-(Trifluoromethyl)acetophenone 709-63-7
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
100kgs/month
Release date
2021-11-26
Qiuxian Baitai New Material Co., LTD
Product
4'-(TrifluoroMet 709-63-7
Price
US $10.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
500ton/Month
Release date
2021-07-29

709-63-7, 4'-(Trifluoromethyl)acetophenoneRelated Search:


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