Synthesis
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4'-(Trifluoromethyl)acetophenone

Synthesis
Product Name
4'-(Trifluoromethyl)acetophenone
CAS No.
709-63-7
Chemical Name
4'-(Trifluoromethyl)acetophenone
Synonyms
4-(TRIFLUOROMETHYL)ACETOPHENONE;1-(4-Trifluoromethyl-phenyl)-ethanone;NSC 88346;4-Acetylbe;4-ACETYLBENZOFLUORIDE;On the trifluoroMethyl;4-ACETYLBENZOTRIFLUORIDE;P-TRIFLUOROMETHYLACETOPHENONE;4-(trifluromethyl)acetophenone;4-TRIFLUOROMETHYL BENZYLDEHYDE
CBNumber
CB9717518
Molecular Formula
C9H7F3O
Formula Weight
188.15
MOL File
709-63-7.mol
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4'-(Trifluoromethyl)acetophenone Property

Melting point:
30-33 °C(lit.)
Boiling point:
79-80 °C8 mm Hg(lit.)
Density 
0.92
refractive index 
1.4604
Flash point:
184 °F
storage temp. 
Sealed in dry,Room Temperature
form 
Low Melting Solid
color 
White to faintly yellow
BRN 
1870425
CAS DataBase Reference
709-63-7(CAS DataBase Reference)
NIST Chemistry Reference
4-CF3-C6H4-COCH3(709-63-7)
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Safety

Hazard Codes 
Xi,F
Risk Statements 
36/37/38-11
Safety Statements 
26-36-37/39-16
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29147090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
233188
Product name
4′-(Trifluoromethyl)acetophenone
Purity
98%
Packaging
25g
Price
$112.2
Updated
2024/03/01
Sigma-Aldrich
Product number
233188
Product name
4′-(Trifluoromethyl)acetophenone
Purity
98%
Packaging
5g
Price
$120
Updated
2024/03/01
TCI Chemical
Product number
T1784
Product name
4'-(Trifluoromethyl)acetophenone
Purity
>98.0%(GC)
Packaging
1g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
T1784
Product name
4'-(Trifluoromethyl)acetophenone
Purity
>98.0%(GC)
Packaging
5g
Price
$41
Updated
2024/03/01
Alfa Aesar
Product number
A15529
Product name
4'-(Trifluoromethyl)acetophenone, 98+%
Packaging
5g
Price
$93.65
Updated
2024/03/01
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4'-(Trifluoromethyl)acetophenone Chemical Properties,Usage,Production

Synthesis

41.6 g of chlorocyclohexane (0.35 mol) were added dropwise to a suspension of 4.65 g of lithium particles (0.68 mol) in 350 g of THF at -55 °C, and an addition time of 2 hours was chosen. After >97% chlorocyclohexane conversion by GC (10 hours), a mixture of 38.3 g of 4-bromotrifluorotoluene (0.170 mol) and 7.0 g of acetonitrile (0.170 mol) was added dropwise at the same temperature for 15 minutes. After stirring for an additional 30 minutes at -50°C, the reaction mixture was slowly thawed to room temperature and subjected to an aqueous workup in a conventional manner. The yield of 4-trifluoromethylacetophenone after distillation was 81%.

Chemical Properties

White to faintly yellow low melting solid

Uses

A labelled acetophenone with selective antimycobacterial activity.

General Description

The enantioselective addition of dialkylzinc to 4′-(trifluoromethyl)acetophenone mediated by 1,2-bis(hydroxycamphorsulfonamido)cyclohexenes in the presence of titanium tetraisopropoxide has been investigated. Phosphorescence emission spectra of 4′-(trifluoromethyl)acetophenone has been studied using pulsed source phosphorimetry.

Purification Methods

Purify the ketone by distillation or sublimation in vacuo.[Beilstein 7 IV 1404.]

4'-(Trifluoromethyl)acetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4'-(Trifluoromethyl)acetophenone manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4'-(Trifluoromethyl)acetophenone 709-63-7
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%
Supply Ability
2000tons
Release date
2020-01-16
Shanghai Rlavie Technology Co ltd
Product
4-(Trifluoromethyl)acetophenone 709-63-7
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
100kgs/month
Release date
2021-11-26
Qiuxian Baitai New Material Co., LTD
Product
4'-(TrifluoroMet 709-63-7
Price
US $10.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
500ton/Month
Release date
2021-07-29

709-63-7, 4'-(Trifluoromethyl)acetophenoneRelated Search:


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  • 709-63-7
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