4-Trifluoromethylphenol
Preparation method Chemical Characteristics Uses- Product Name
- 4-Trifluoromethylphenol
- CAS No.
- 402-45-9
- Chemical Name
- 4-Trifluoromethylphenol
- Synonyms
- TFMPO;P-Trifluoromethyl;TRIFLUORO-PARA-CRESOL;Fluoxetine Impurity 4;4-HYDROXYBENZOTRIFLUORI;4-trifluorotoluolphenol;p-TrifluoroMethylphenyl;Fluoxetine EP Impurity D;α,α,α-Trifluoro-p-cresol;4-HYDROXYBENZOTRIFLUORIDE
- CBNumber
- CB6371577
- Molecular Formula
- C7H5F3O
- Formula Weight
- 162.11
- MOL File
- 402-45-9.mol
4-Trifluoromethylphenol Property
- Melting point:
- 45-47 °C(lit.)
- Boiling point:
- 71.5-72 °C (8 mmHg)
- Density
- 1.3226 (estimate)
- Flash point:
- 183 °F
- storage temp.
- 0-6°C
- pka
- pK1:8.675 (25°C)
- form
- Crystals
- color
- White to yellow-brown
- BRN
- 1637019
- InChIKey
- BAYGVMXZJBFEMB-UHFFFAOYSA-N
- CAS DataBase Reference
- 402-45-9(CAS DataBase Reference)
- NIST Chemistry Reference
- p-Hydroxybenzotrifluoride(402-45-9)
- EPA Substance Registry System
- 4-(Trifluoromethyl)phenol (402-45-9)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-37/38-41-36/37/38
- Safety Statements
- 26-39-24/25
- RIDADR
- UN 2926 4.1/PG 2
- WGK Germany
- 3
- Hazard Note
- Irritant/Keep Cold
- PackingGroup
- Ⅱ
- HS Code
- 29081000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H228Flammable solid
H301Toxic if swalloed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 178470
- Product name
- 4-(Trifluoromethyl)phenol
- Purity
- 97%
- Packaging
- 5g
- Price
- $83.6
- Updated
- 2020/08/18
- Product number
- 178470
- Product name
- 4-(Trifluoromethyl)phenol
- Purity
- 97%
- Packaging
- 1g
- Price
- $27.3
- Updated
- 2020/08/18
- Product number
- H0644
- Product name
- 4-Hydroxybenzotrifluoride
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $92
- Updated
- 2020/06/24
- Product number
- H0644
- Product name
- 4-Hydroxybenzotrifluoride
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $273
- Updated
- 2020/06/24
- Product number
- 8.41244
- Product name
- 4-Hydroxybenzotrifluoride for synthesis. CAS 402-45-9, molar mass 162.11 g/mol., for synthesis
- Packaging
- 8412440001
- Price
- $50.4
- Updated
- 2020/08/18
4-Trifluoromethylphenol Chemical Properties,Usage,Production
Preparation method
Chlorosilane and bromotrifluoromethane at-59℃form trifluoromethylsilane. Trifluoromethylsilane and benzoquinone in the presence of catalyst form 4-triethylsiloxy-4-trifluoromethyl-2,5-cyclohexadien-1-ketone which is reduced by zinc powder to p-trifluoromethylphenol with a yield of 71%. This method avoids the use of hydrofluoric acid in the traditional process but should be carried out under anhydrous conditions.If there were water trifluoromethyl silane would rapidly become silanol under the effect of water and alkali. The catalyst used in the reaction is alkali of which the strength has nothing to do with the catalytic activity. By now the role of catalyst is still unknown but the reaction can not proceed without catalyst.
Chemical Characteristics
Off-white crystal
Uses
For intermediate of medicine and pesticide.
Chemical Properties
White to yellowish-brown crystals
Uses
Intermediates of Liquid Crystals
Synthesis Reference(s)
The Journal of Organic Chemistry, 54, p. 2873, 1989 DOI: 10.1021/jo00273a020
4-Trifluoromethylphenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Trifluoromethylphenol manufacturers
- Product
- 4-Trifluoromethylphenol 402-45-9
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-08-02