2-(Trifluoromethyl)benzoic acid
Uses- Product Name
- 2-(Trifluoromethyl)benzoic acid
- CAS No.
- 433-97-6
- Chemical Name
- 2-(Trifluoromethyl)benzoic acid
- Synonyms
- 2-Carboxybenzotrifluoride;2-(Trifluoromethyl)benzoic;SODIUM HEXAFLUOROANTIMONATE(V);Flutolanil Impurity 1;ANTIMONY SODIUM FLUORIDE;SODIUM ANTIMONY FLUORIDE;2-TRIFLUROMETHYLBENZOIC ACID;α,α,α-trifluoro-o-toluic acid;à,à,à-trifluoro-o-toluic acid;2，2，2-trifluoro-o-toluic acid
- CBNumber
- CB3709678
- Molecular Formula
- C8H5F3O2
- Formula Weight
- 190.12
- MOL File
- 433-97-6.mol
2-(Trifluoromethyl)benzoic acid Property
- Melting point:
- 107-110 °C(lit.)
- Boiling point:
- 247 °C753 mm Hg(lit.)
- Density
- 3.375 g/mL at 25 °C(lit.)
- Flash point:
- 247-254°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 3.20±0.36(Predicted)
- form
- Crystalline Powder
- color
- Slightly yellow to yellow-brown
- Water Solubility
- 4.8g/L(25 ºC)
- BRN
- 976984
- InChI
- 1S/C8H5F3O2/c9-8(10,11)6-4-2-1-3-5(6)7(12)13/h1-4H,(H,12,13)
- InChIKey
- FBRJYBGLCHWYOE-UHFFFAOYSA-N
- SMILES
- OC(=O)c1ccccc1C(F)(F)F
- CAS DataBase Reference
- 433-97-6(CAS DataBase Reference)
- NIST Chemistry Reference
- «alpha»,«alpha»,«alpha»-Trifluoro-o-toluic acid(433-97-6)
- EPA Substance Registry System
- Benzoic acid, 2-(trifluoromethyl)- (433-97-6)
Safety
- Hazard Codes
- Xn,N,Xi
- Risk Statements
- 20/22-51/53-36/37/38
- Safety Statements
- 61-36-26
- RIDADR
- UN 1549 6.1/PG 3
- WGK Germany
- 2
- F
- 1-10
- TSCA
- TSCA listed
- HazardClass
- IRRITANT
- HS Code
- 29163990
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 196886
- Product name
- 2-(Trifluoromethyl)benzoic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $37.4
- Updated
- 2025/07/31
- Product number
- T1302
- Product name
- 2-(Trifluoromethyl)benzoic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 10g
- Price
- $51
- Updated
- 2025/07/31
- Product number
- T790625
- Product name
- 2-(Trifluoromethyl)benzoic Acid
- Packaging
- 10g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- JK262647
- Product name
- 2-(Trifluoromethyl)benzoic Acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $62
- Updated
- 2021/12/16
- Product number
- 2821-3-02
- Product name
- 2-(Trifluoromethyl)benzoic acid
- Purity
- 98%
- Packaging
- 100g
- Price
- $69
- Updated
- 2021/12/16
2-(Trifluoromethyl)benzoic acid Chemical Properties,Usage,Production
Uses
2-(Trifluoromethyl)benzoic Acid is used in biochemical genetics studies such as Plasmid-encoded phthalate catabolic pathway in Arthrobacter keyseri 12B.
Chemical Properties
slightly yellow to yellow-brown crystalline powder
Uses
2-(Trifluoromethyl)benzoic Acid is used in biochemical genetics studies such as Plasmid-encoded phthalate catabolic pathway in Arthrobacter keyseri 12B.
Uses
2-(Trifluoromethyl)benzoic acid was used in the synthesis of 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety. It was also used to investigate the binding of 2-pyridinone and amino acid derivative as ligands with chaperones PapD and FimC by surface plasmon resonance and 1HNMR spectroscopy.
Definition
ChEBI: A benzoic acid carrying a trifluoromethyl substituent at the 2-position.
Synthesis
In a 5L stainless steel high-pressure reactor equipped with a mixer and a thermometer, the temperature was lowered to below 5C, hydrogen fluoride and 2-trichloromethyl dichlorobenzyl were added sequentially and the mass ratio of the two was 0.2:1, and then the catalyst perfluorooctane sulfonyl fluoride was added, and the mass ratio of 2-trichloromethyl dichlorobenzyl to the catalyst was 1:0.001, and the reaction pressure was controlled to be 2.5-2.8MPa for 4 hours. The temperature was raised to 80-90C, and the reaction pressure was controlled at 2.5-2.8 MPa for 4 hours. Sampling, GC detection, the intermediate product 2-difluoromonochloromethyl dichlorobenzyl content of 0.3%. At the end of the reaction, the excess hydrogen fluoride was removed by nitrogen purging, and neutralized with aqueous potassium carbonate to pH=6-7. After standing, the product 2-trifluoromethyl dichlorobenzyl chloride was isolated with 96.6% content and 94.1% yield.
The fluorination reaction product 2-trifluoromethyl dichlorobenzyl and nitric acid were reacted to obtain the target compound 2-trifluoromethyl benzoic acid after acid hydrolysis and oxidation reaction.
2-(Trifluoromethyl)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(Trifluoromethyl)benzoic acid manufacturers
- Product
- 2-(Trifluoromethyl)benzoic acid 433-97-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-24
- Product
- 2-(Trifluoromethyl)benzoic acid 433-97-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-25
- Product
- 2-(Trifluoromethyl)benzoic acid 433-97-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-11