Uses
ChemicalBook > CAS DataBase List > 3-(Trifluoromethyl)benzaldehyde

3-(Trifluoromethyl)benzaldehyde

Uses
Product Name
3-(Trifluoromethyl)benzaldehyde
CAS No.
454-89-7
Chemical Name
3-(Trifluoromethyl)benzaldehyde
Synonyms
MTF-BAD;3-(three fluoroMethyl;Cinacalcet Impurity 56;3-TRIFLUORMETHYLBENZALDEHYDE;m-Trifuoromethylbenzaldehyde;M-TRIFLUOROMETHYLBENZALDEHYDE;3-TRIFLUOROMETHYLBENZYLDEHYDE;Alpha-Trifluoro-M-tolualdehyde;A,A,A-TRIFLUORO-3-TOLUALDEHYDE;A,A,A-TRIFLUORO-M-TOLUALDEHYDE
CBNumber
CB2759919
Molecular Formula
C8H5F3O
Formula Weight
174.12
MOL File
454-89-7.mol
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3-(Trifluoromethyl)benzaldehyde Property

Boiling point:
83-86 °C30 mm Hg(lit.)
Density 
1.301 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.465(lit.)
Flash point:
155 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Liquid
color 
Clear colorless to very slightly orange
Specific Gravity
1.301
Sensitive 
Air Sensitive
BRN 
2327537
InChIKey
NMTUHPSKJJYGML-UHFFFAOYSA-N
CAS DataBase Reference
454-89-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzaldehyde, 3-(trifluoromethyl)-(454-89-7)
EPA Substance Registry System
Benzaldehyde, 3-(trifluoromethyl)- (454-89-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN3082 - class 9 - PG 3 - DOT NA1993 - Environmentally hazardous substances, liquid, n.o.s. HI: all (not BR)
WGK Germany 
3
10-23
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29130000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
196878
Product name
3-(Trifluoromethyl)benzaldehyde
Purity
97%
Packaging
25g
Price
$42.8
Updated
2024/03/01
Sigma-Aldrich
Product number
196878
Product name
3-(Trifluoromethyl)benzaldehyde
Purity
97%
Packaging
5g
Price
$61.8
Updated
2024/03/01
TCI Chemical
Product number
T1399
Product name
3-(Trifluoromethyl)benzaldehyde
Purity
>95.0%(GC)
Packaging
5g
Price
$34
Updated
2024/03/01
TCI Chemical
Product number
T1399
Product name
3-(Trifluoromethyl)benzaldehyde
Purity
>95.0%(GC)
Packaging
25g
Price
$98
Updated
2024/03/01
Alfa Aesar
Product number
A10463
Product name
3-(Trifluoromethyl)benzaldehyde, 97%
Packaging
5g
Price
$48.65
Updated
2024/03/01
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3-(Trifluoromethyl)benzaldehyde Chemical Properties,Usage,Production

Uses

3-(Trifluoromethyl)benzaldehyde is used as a reagent in the synthesis of 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-γ-butyrolactones as potent antitumor agents. Also used as a reagent in the synthesis of novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitors.

Chemical Properties

CLEAR COLOURLESS TO VERY SLIGHTLY ORANGE LIQUID

Uses

3-(Trifluoromethyl)benzaldehyde is used as a reagent in the synthesis of 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-╬│-butyrolactones as potent antitumor agents. Also used as a reagent in the synthesis of novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitors.

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 426, 1946 DOI: 10.1021/ja01207a024

General Description

Aldol reaction of 3-(trifluoromethyl)benzaldehyde with hydroxyacetone in the aldolase antibody 38C2-ionic liquid system has been investigated.

3-(Trifluoromethyl)benzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(Trifluoromethyl)benzaldehyde Suppliers

CHANGZHOU FLUORIDE CHEMICAL CO.,LTD
Tel
0086-519-89892883 15995021858
Fax
0519-85227531
Email
info@fluoridechem.com
Country
China
ProdList
80
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58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd.
Tel
0519-85195575 15861192208
Fax
85195585
Email
850305@sunkechem.com
Country
China
ProdList
75
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69
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
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INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
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3572
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
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57
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
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55
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View Lastest Price from 3-(Trifluoromethyl)benzaldehyde manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3-(Trifluoromethyl)benzaldehyde 454-89-7
Price
US $20.00-7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-08-06
Shaanxi Dideu Medichem Co. Ltd
Product
3-(Trifluoromethyl)benzaldehyde 454-89-7
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000Tons
Release date
2024-08-04
Hebei Kingfiner Technology Development Co.Ltd
Product
3-(Trifluoromethyl)benzaldehyde 454-89-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000kg
Release date
2024-06-24

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