4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID

Product Name: 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID
CAS No.: 53473-36-2
Chemical Name: 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID
Synonyms: Cinacalcet-29;Sinacase Impurity 53.;Cinacalcet Impurity 42;P-Trifluoromethyl benzylacetic acid;4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID;P-trifluoromethyl phenylpropionic acid;4-(TRIFLUOROMETHYL)PHENYLPROPIONIC ACID;3-(4-TrifluroMethylphenyl)propanoic acid;4-(TrifluoroMethyl)-benzenepropanoic acid;4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID 95%
CBNumber: CB0376626
Molecular Formula: C10H9F3O2
Formula Weight: 218.17
MOL File: 53473-36-2.mol

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4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID Property

Melting point:: 106-110 °C(lit.)
Boiling point:: 0°C
Density: 1.307±0.06 g/cm3(Predicted)
Flash point:: 0°C
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 4.54±0.10(Predicted)
form: Crystalline Powder or Solid
color: White to light brown
InChI: InChI=1S/C10H9F3O2/c11-10(12,13)8-4-1-7(2-5-8)3-6-9(14)15/h1-2,4-5H,3,6H2,(H,14,15)
InChIKey: OEIUMLSCWINLBB-UHFFFAOYSA-N
SMILES: C1(CCC(O)=O)=CC=C(C(F)(F)F)C=C1
CAS DataBase Reference: 53473-36-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 457035
Product name: 4-(Trifluoromethyl)hydrocinnamic acid
Purity: 95%
Packaging: 10g
Price: $332
Updated: 2023/06/20

Sigma-Aldrich

Product number: 457035
Product name: 4-(Trifluoromethyl)hydrocinnamic acid
Purity: 95%
Packaging: 1g
Price: $42.2
Updated: 2023/01/07

TCI Chemical

Product number: T2927
Product name: 3-[4-(Trifluoromethyl)phenyl]propionic Acid
Purity: >98.0%(T)
Packaging: 1g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: T2927
Product name: 3-[4-(Trifluoromethyl)phenyl]propionic Acid
Purity: >98.0%(T)
Packaging: 5g
Price: $128
Updated: 2025/07/31

TRC

Product number: T796565
Product name: 4-(Trifluoromethyl)hydrocinnamic acid
Packaging: 1g
Price: $50
Updated: 2021/12/16

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4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID Chemical Properties,Usage,Production

Chemical Properties

White to pale yellow crystalline powder

Uses

4-(Trifluoromethyl)hydrocinnamic Acid acts as a reagent in the synthesis of (poly)fluorinated neprilysin inhibitor. It is also applied in pesticides, medicines, dyes and in functional materials preparation because of it’s excellent bioactive properties.

Synthesis

16642-92-5

53473-36-2

GENERAL STEPS: (E)-4-Trifluoromethylcinnamic acid (10.0 g, 46.3 mmol) was mixed with 10 wt% Pd/C catalyst (250 mg) in ethanol (100 mL). The reaction mixture was placed under hydrogen atmosphere (6 bar) and the reaction was stirred at room temperature for 21 hours. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to remove the solvent to afford 3-(4-trifluoromethyl)phenylpropionic acid as a white solid (10.1 g, 46.1 mmol, 100% yield). The structure of the product was confirmed by 1H-NMR (CDCl3): δ 2.73 (t, J = 7.6 Hz, 2H), 3.03 (t, J = 7.6 Hz, 2H), 7.33 (d, J = 8.0 Hz, 2H), 7.56 (d, J = 8.1 Hz, 2H).

References

[1] Patent: WO2010/64212, 2010, A1. Location in patent: Page/Page column 23
[2] Canadian Journal of Chemistry, 2012, vol. 90, # 9, p. 758 - 761
[3] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 10, p. 3557 - 3567
[4] Patent: US2010/10226, 2010, A1. Location in patent: Page/Page column 7-8
[5] Patent: US2010/305325, 2010, A1. Location in patent: Page/Page column 2; 3; 8

4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID Preparation Products And Raw materials

Raw materials

Hexane Ethanol Piperidine Palladium 4-(Trifluoromethyl)benzaldehyde Hydrochloric acid Hydrogen Pyridine Malonic acid

Preparation Products

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4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID Suppliers

China 166 Europe 2 Germany 1 India 8 Italy 1 Japan 1 Switzerland 1 Ukraine 2 United Kingdom 6 United States 20 Global 208

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View Lastest Price from 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID 53473-36-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-29

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID 53473-36-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID 53473-36-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-07-11

53473-36-2, 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACIDRelated Search:

3-[o-(alpha,alpha,alpha-trifluorotolyl)]propionic acid 3-(3-Trifluoromethylphenyl)propionic acid Cinacalcet Impurity B Cinacalcet Impurity 38 HCl (E)-m-(trifluoromethyl)cinnamic acid 1-NAPHTHALEN-2-YL-ETHYLAMINE Cinacalcet IMpurity 7 (R)-1-(Naphthalen-2-yl)ethanamine hydrochloride (1R)-1-(5-methylnaphthalen-1-yl)ethan-1-amine Cinacalcet IMpurity 3 Cinacalcet Impurity 46 3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL Methanesulfonic acid 3-(3-trifluoroMethylphenyl)propyl ester cinacalcet iMpurity 4 N-(1-(naphthalen-1-yl)ethyl)forMaMide Cinacalcet impurity C Cinacalcet Impurity 45 Cinacalcet Impurity 39 (Mixture of Diastereomers)

4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID

3-(4-(TRIFLUOROMETHYL)PHENYL)PROPANOIC ACID

3-[4-(TRIFLUOROMETHYL)PHENYL]PROPIONIC ACID

4-(Trifluoromethyl)HydrocinnamicAcid/P-(Trifluoromethyl)PhenylpropionicAcid/P-(Trifluoromethylphenyl)PropionicAcid

4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID 95%

P-Trifluoromethyl benzylacetic acid

4-(TRIFLUOROMETHYL)PHENYLPROPIONIC ACID

4-(Trifluoromethyl)hydrocinnamic acid,95%

3-(4-(Trifluoromethyl)phenyl)propanoic acid ,97%

4-(TrifluoroMethyl)-benzenepropanoic acid

4-(4-(trifluoromethyl)phenyl)propanoic acid

Cinacalcet-29

4-(Trifluoromethyl)hydrocinnamic acid, 4-(2-Carboxyethyl)benzotrifluoride

Benzenepropanoic acid, 4-(trifluoroMethyl)-

3-(4-TrifluroMethylphenyl)propanoic acid

Cinacalcet Impurity 42

P-trifluoromethyl phenylpropionic acid

3-[4-(Trifluoromethyl)phenyl]propionicAci

3-(4-(Trifluoromethyl)phenyl)propanoic acid (Cinacalcet Impurity)

53473-36-2 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID

(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)-N-(3-(3-(trifluoromethyl)phenyl)propanoyl)propanamide

Sinacase Impurity 53.

53473-36-2

129512-52-0

CF3C6H4CH2CH2CO2H

C10

Carboxylic Acids

Carbonyl Compounds

Building Blocks

Organic Building Blocks

Fluorine series

Acids and Derivatives