Chalcone
- Product Name
- Chalcone
- CAS No.
- 94-41-7
- Chemical Name
- Chalcone
- Synonyms
- (E)-CHALCONE;BENZALACETOPHENONE;CHALKONE;1,3-DIPHENYL-2-PROPENONE;CHALCONE;CHALCONE;AI3-00946;NSC 26612;CCRIS 2213;Chalcone b
- CBNumber
- CB0746254
- Molecular Formula
- C15H12O
- Formula Weight
- 208.26
- MOL File
- 94-41-7.mol
Chalcone Property
- Melting point:
- 55-59 °C
- Boiling point:
- 208 °C25 mm Hg(lit.)
- Density
- d462 1.0712
- refractive index
- nD62 1.6458
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- dioxane: soluble1g/10 mL, clear, colorless
- form
- Granular Powder
- color
- Yellow
- Merck
- 14,2037
- BRN
- 1210466
- LogP
- 3.080
- CAS DataBase Reference
- 94-41-7(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Propen-1-one, 1,3-diphenyl- (94-41-7)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37
- Safety Statements
- 22-36/37/39-45
- WGK Germany
- 3
- RTECS
- UD5576750
- HS Code
- 29143900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 11970
- Product name
- 1,3-Diphenyl-2-propenone
- Purity
- ≥98.0% (GC)
- Packaging
- 100g
- Price
- $71.1
- Updated
- 2023/06/20
- Product number
- C0071
- Product name
- Chalcone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $31
- Updated
- 2024/03/01
- Product number
- C0071
- Product name
- Chalcone
- Purity
- >98.0%(GC)
- Packaging
- 100g
- Price
- $82
- Updated
- 2024/03/01
- Product number
- C0071
- Product name
- Chalcone
- Purity
- >98.0%(GC)
- Packaging
- 500g
- Price
- $200
- Updated
- 2024/03/01
- Product number
- C291855
- Product name
- Chalcone
- Packaging
- 250g
- Price
- $365
- Updated
- 2021/12/16
Chalcone Chemical Properties,Usage,Production
Description
Chalcone is the organic compound C6H5C(O)CH=CHC6H5. It is an α,β-unsaturated ketone. A variety of important biological compounds are known collectively as chalcones or chalconoids.They show antibacterial, antifungal, antitumor and anti-inflammatory properties. They are also intermediates in the biosynthesis of flavonoids, which are substances widespread in plants and with an array of biological activities. Chalcones are also intermediates in the Auwers synthesis of flavones.
Chemical Properties
light yellow powder
Uses
1,3-Diphenyl-2-propenone was used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines.
Uses
Chalcone is used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines. It also inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase.
Definition
ChEBI: A member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group.
Preparation
Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.
Chalcones can be prepared by an aldol condensation between a benzaldehyde and an acetophenone in the presence of sodium hydroxide as a catalyst.
This reaction has been found to work without any solvent at all - a solid-state reaction. The reaction between substituted benzaldehydes and acetophenones has been used to demonstrate green chemistry in undergraduate chemistry education.In a study investigating green chemistry synthesis, chalcones were also synthesized from the same starting materials in high temperature water (200 to 350 °C).
Biological Activity
1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.
Biochem/physiol Actions
1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.
Safety Profile
Poison by intravenous route. See also KETONES. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification Methods
Crystallise it from EtOH by warming to 50o (about 5mL/g), iso-octane, or toluene/pet ether, or recrystallise it from MeOH, and then twice from hexane. SKIN IRRITANT. [Beilstein 7 IV 1658.]
Chalcone Preparation Products And Raw materials
Raw materials
Preparation Products
Chalcone Suppliers
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View Lastest Price from Chalcone manufacturers
- Product
- Chalcone 94-41-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-30
- Product
- Chalcone 94-41-7
- Price
- US $8.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- Chalcone 94-41-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-10-25