ChemicalBook > CAS DataBase List > Chalcone

Chalcone

Product Name
Chalcone
CAS No.
94-41-7
Chemical Name
Chalcone
Synonyms
(E)-CHALCONE;BENZALACETOPHENONE;CHALKONE;1,3-DIPHENYL-2-PROPENONE;CHALCONE;CHALCONE;AI3-00946;NSC 26612;CCRIS 2213;Chalcone b
CBNumber
CB0746254
Molecular Formula
C15H12O
Formula Weight
208.26
MOL File
94-41-7.mol
More
Less

Chalcone Property

Melting point:
55-59 °C
Boiling point:
208 °C25 mm Hg(lit.)
Density 
d462 1.0712
refractive index 
nD62 1.6458
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
dioxane: soluble1g/10 mL, clear, colorless
form 
Granular Powder
color 
Yellow
Merck 
14,2037
BRN 
1210466
LogP
3.080
CAS DataBase Reference
94-41-7(CAS DataBase Reference)
EPA Substance Registry System
2-Propen-1-one, 1,3-diphenyl- (94-41-7)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37
Safety Statements 
22-36/37/39-45
WGK Germany 
3
RTECS 
UD5576750
HS Code 
29143900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
11970
Product name
1,3-Diphenyl-2-propenone
Purity
≥98.0% (GC)
Packaging
100g
Price
$71.1
Updated
2023/06/20
TCI Chemical
Product number
C0071
Product name
Chalcone
Purity
>98.0%(GC)
Packaging
25g
Price
$31
Updated
2024/03/01
TCI Chemical
Product number
C0071
Product name
Chalcone
Purity
>98.0%(GC)
Packaging
100g
Price
$82
Updated
2024/03/01
TCI Chemical
Product number
C0071
Product name
Chalcone
Purity
>98.0%(GC)
Packaging
500g
Price
$200
Updated
2024/03/01
TRC
Product number
C291855
Product name
Chalcone
Packaging
250g
Price
$365
Updated
2021/12/16
More
Less

Chalcone Chemical Properties,Usage,Production

Description

Chalcone is the organic compound C6H5C(O)CH=CHC6H5. It is an α,β-unsaturated ketone. A variety of important biological compounds are known collectively as chalcones or chalconoids.They show antibacterial, antifungal, antitumor and anti-inflammatory properties. They are also intermediates in the biosynthesis of flavonoids, which are substances widespread in plants and with an array of biological activities. Chalcones are also intermediates in the Auwers synthesis of flavones.

Chemical Properties

light yellow powder

Uses

1,3-Diphenyl-2-propenone was used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines.

Uses

Chalcone is used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines. It also inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase.

Definition

ChEBI: A member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group.

Preparation

Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.
Chalcones can be prepared by an aldol condensation between a benzaldehyde and an acetophenone in the presence of sodium hydroxide as a catalyst.

This reaction has been found to work without any solvent at all - a solid-state reaction. The reaction between substituted benzaldehydes and acetophenones has been used to demonstrate green chemistry in undergraduate chemistry education.In a study investigating green chemistry synthesis, chalcones were also synthesized from the same starting materials in high temperature water (200 to 350 °C).

Biological Activity

1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.

Biochem/physiol Actions

1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.

Safety Profile

Poison by intravenous route. See also KETONES. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Crystallise it from EtOH by warming to 50o (about 5mL/g), iso-octane, or toluene/pet ether, or recrystallise it from MeOH, and then twice from hexane. SKIN IRRITANT. [Beilstein 7 IV 1658.]

Chalcone Preparation Products And Raw materials

Raw materials

Acetone trans-Chalcone

Preparation Products

More
Less

Chalcone Suppliers

Americas 1 Belgium 1 China 132 Czech 1 Europe 3 Germany 4 India 24 Japan 4 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 9 United States 26 Global 211
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18501085097
Fax
010-89508210
Email
sales3.gd@hwrkchemical.com
Country
China
ProdList
7583
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7815
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11714
Advantage
57
Beijing Taiya Jie Technology Development Co., Ltd.
Tel
021-33690831-8001 13552411790
Fax
021-33690831
Email
postmaster@tyjchem.cn
Country
China
ProdList
1542
Advantage
55
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
Advantage
60
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4941
Advantage
60
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6139
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19918
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
021-50430803 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9352
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22519
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4528
Advantage
56
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
Shanghai DiBai Chemicals Co., Ltd.
Tel
021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3993
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17982
Advantage
56
Beijing FYF Chemicals Co., Ltd
Tel
010-61647239; 15318973357
Fax
010-57903446
Email
1460285141@qq.com
Country
China
ProdList
2948
Advantage
58
Shanghai CanSpecsci Instrument Co., Ltd.
Tel
400-6087598 15021221957
Fax
4006087598-8012
Email
order@canspecsci.com
Country
China
ProdList
2071
Advantage
56
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15878
Advantage
55
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8147
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4901
Advantage
55
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
7059
Advantage
55
Chengdu RunZeBenTu Chemical Co., Ltd
Tel
028-88469284 18000562381
Email
rzbtsj@163.com
Country
China
ProdList
9958
Advantage
56
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10457
Advantage
58
Shanghai ChengShao Biological Technology Co., Ltd.
Tel
021-61847300 13341622919
Fax
021-61847300
Email
shcss01@163.com
Country
China
ProdList
4809
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
9859
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29797
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Shanghai Uteam Biotechnology Co., Ltd.
Tel
021-36031160 13311776681
Email
3338195766@QQ.com
Country
China
ProdList
5175
Advantage
55
Shanghai Biological Technology Development Co., Ltd.
Tel
021-69955236-807 13918189704
Fax
021-65211385
Email
chinaruji@chinaruji.com
Country
China
ProdList
5176
Advantage
55
Guangzhou Jhd Chemical Reagent Co., Ltd.
Tel
020-84383047
Fax
020-84380294
Email
sales@jhd.com.cn
Country
China
ProdList
9190
Advantage
65
JinJin Le Chemical Co., Ltd
Tel
10106090
Email
jjlchem2@163.com
Country
China
ProdList
9986
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
021-021-52271985 17721149837
Fax
+86 (21) 52271987
Email
sales@9dingchem.com
Country
China
ProdList
19806
Advantage
60
Shanghai QiQiao Biological Technology Co., Ltd.
Tel
021-37653318; 15221675714
Email
515366396@qq.com
Country
China
ProdList
2089
Advantage
58
Shanghai He Huan Chemical Co., Ltd.
Tel
021-60345187 13917602471
Fax
021-60345187
Email
lzz841106@aliyun.com
Country
China
ProdList
9908
Advantage
58
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6038 18902104717
Email
sales@heowns.com
Country
China
ProdList
20512
Advantage
60
Weichang Yuanhe Biotech R&D Co.,Ltd.
Tel
0314-7886310 18830416512
Fax
0314-7886310
Email
weichangyuanhe@163.com
Country
China
ProdList
146
Advantage
58
Henan Alfachem Co.,Ltd.
Tel
0371-0371-55051623 18137891487
Fax
QQ：2853979817
Email
2853979817@qq.com
Country
China
ProdList
9968
Advantage
58
3A Chemicals
Tel
400-668-9898
Fax
010-51582189
Email
service@3achem.com
Country
China
ProdList
20569
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
400-400-400-9004166 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52712
Advantage
58
Shanghai wencai New Material Technology Co., Ltd.
Tel
15721586846
Fax
15721586846
Email
wencaimat@163.com
Country
China
ProdList
2796
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2815688 13927872512
Fax
0751-8963795
Email
3007421951@qq.com
Country
China
ProdList
10071
Advantage
58
More
Less

View Lastest Price from Chalcone manufacturers

Henan Fengda Chemical Co., Ltd
Product
Chalcone 94-41-7
Price
US $8.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09
Hebei Mojin Biotechnology Co., Ltd
Product
Chalcone 94-41-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-10-25
Hebei Guanlang Biotechnology Co., Ltd.
Product
Chalcone 94-41-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2022-11-14

94-41-7, ChalconeRelated Search:

2',4,4'-TRIHYDROXY-3-METHOXY CHALCONE 2',3,4,4'-Tetrahydroxy-trans-chalcone trans-Chalcone Styrene 4-Chloro-4'-methoxy-trans-chalcone (E)-2',4-Dihydroxy-4'-(β-D-glucopyranosyloxy)chalcone (E)-4'-(Dimethylamino)chalcone 4-Diethylamino-α-methyl-3',4',5'-trimethoxy-trans-chalcone 4-Amino-β-methyl-3',4',5'-trimethoxy-trans-chalcone α-Methyl-2',3',4'-trimethoxy-trans-chalcone 4-Acetylamino-3',4',5'-trimethoxy-trans-chalcone 4-Nitro-cis-chalcone 2'-HYDROXY-6'-METHYL-3,4-METHYLENEDIOXY CHALCONE 4-Butoxy-3',4',5'-trimethoxy-trans-chalcone 3-Dimethylamino-3',4',5'-trimethoxy-trans-chalcone 3,4'-Dinitro-trans-chalcone 4-Diethylamino-α-methyl-2',3',4'-trimethoxy-trans-chalcone 4-Nitro-3',4',5'-trimethoxy-trans-chalcone

  • styrylphenylketone
  • BENZALACETOPHENONE
  • BENZYLIDINEACETOPHENONE
  • (E)-CHALCONE
  • CHALCONE
  • CHALKONE
  • 3-PHENYLACRYLOPHENONE
  • 1,3-DIPHENYLPROP-2-EN-1-ONE
  • 1,3-DIPHENYL-3-PROPEN-1-ONE
  • 1,3-DIPHENYL-2-PROPEN-I-ONE
  • 1,3-DIPHENYL-2-PROPENONE
  • (2E)-1,3-DIPHENYLPROP-2-EN-1-ONE
  • 2-BENZALACETOPHENONE
  • 2-BENZYLIDENEACETOPHENONE
  • Glycine USP24/Food grade
  • Benzylideneacetophenone97%Min
  • Chalcone, 96% (Benzylidenacetophenon)
  • Chalcone,98+%
  • trans-Chalcone,98+%
  • 2-Propen-1-one, 1,3-diphenyl-
  • (E)-1,3-diphenylprop-2-en-1-one
  • (2E)-1,3-Diphenyl-2-propen-1-one
  • 1,3-Diphenyl-1-propen-3-one
  • 1,3-diphenyl-2-propen-1-on
  • 1,3-Diphenylpropenone
  • 1-benzoyl-1-phenylethene
  • 1-Benzoyl-2-phenylethene
  • 1-Benzoyl-2-phenylethylene
  • 1-Phenyl-2-benzoylethylene
  • 3-phenyl-acrylophenon
  • Acrylophenone, 3-phenyl-
  • alpha-Benzylideneacetophenone
  • Benzylidenecetophenone
  • beta-Benzoylstyrene
  • beta-Phenylacrylophenone
  • Cinnamophenone
  • omega-Benzylideneacetophenone
  • Phenyl 2-phenylvinyl ketone
  • phenyl2-phenylvinylketone
  • Styryl phenyl ketone
  • PHENYL STYRYL KETONE
  • TRANS-BENZYLIDENEACETOPHENONE
  • BENZALACETOPHENONE pure
  • Chalcone,97%
  • Chalcone 97%
  • Chalcone 97% / trans-Benzylideneacetophenone
  • Chalcone, 97% 100GR
  • 2-Benzalacetophenone 2-Benzylideneacetophenone 1,3-Diphenyl-2-propen-1-one Phenyl Styryl Ketone
  • BENZYLIDENEACETOPHENONE FOR SYNTHESIS
  • 1,3-Diphenyl-2-propenone >=98.0% (GC)
  • Benzalacetophenone, 1,3-Diphenylprop-2-en-1-one
  • -2-propenone
  • (Z)-1,3-diphenylprop-2-en-1-one
  • AI3-00946
  • CCRIS 2213
  • NSC 26612
  • Chalcone &gt
  • Chalcone b