Epalrestat
- Product Name
- Epalrestat
- CAS No.
- 82159-09-9
- Chemical Name
- Epalrestat
- Synonyms
- 3-thiazolidineaceticacid,5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo;2-((Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid;e)-(e;Ipast;Eabeth;Epatat;Ipastat;Epa－API;Kinedak;Epalrest
- CBNumber
- CB6312501
- Molecular Formula
- C15H13NO3S2
- Formula Weight
- 319.4
- MOL File
- 82159-09-9.mol
Epalrestat Property
- Melting point:
- 210-217 C
- Boiling point:
- 516.8±60.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- pka
- 3.62±0.10(Predicted)
- form
- powder
- color
- yellow to orange
- Merck
- 14,3605
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
- InChI
- InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-
- InChIKey
- CHNUOJQWGUIOLD-NFZZJPOKSA-N
- SMILES
- S1/C(=C\C(\C)=C\C2=CC=CC=C2)/C(=O)N(CC(O)=O)C1=S
Safety
- RIDADR
- 2811
- WGK Germany
- 3
- RTECS
- XJ5131855
- HS Code
- 2932.99.7000
- HazardClass
- 6.1
- PackingGroup
- II
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML0527
- Product name
- Epalrestat
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $125.4
- Updated
- 2025/07/31
- Product number
- SML0527
- Product name
- Epalrestat
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $510
- Updated
- 2025/07/31
- Product number
- E0906
- Product name
- Epalrestat
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $135
- Updated
- 2025/07/31
- Product number
- E0906
- Product name
- Epalrestat
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $337
- Updated
- 2025/07/31
- Product number
- 15214
- Product name
- Epalrestat
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $73
- Updated
- 2024/03/01
Epalrestat Chemical Properties,Usage,Production
Description
Epalrestat is the second aldose reductase inhibitor to be introduced worldwide and the first to be launched in Japan. The compound is indicated for the treatment of diabetic neuropathy. It is also being investigated for diabetic retinopathy and nephropathy.
Chemical Properties
Red Solid
Originator
Ono (Japan)
Uses
Epalrestat has been used as an aldose reductase inhibitor:
- in the dahomey larvae diet fed forDrosophila
- for non-irradiated and X-ray irradiated human aldose reductase
- to test its protective effect in mice with bleomycin-induced pulmonary fibrosis
Uses
Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM
Uses
An aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.
Definition
ChEBI: A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.
brand name
Kinedak
Biochem/physiol Actions
Epalrestat inhibits Aldose Reductase (AR) involved in the rate limiting step in the conversion of glucose to sorbitol under hyperglycemic conditions. Aldose reductase has been the target of multiple clinical investigatons to treat diabetic neuropathy and retinopathy. Epalrestat is an approved drug in Japan and India, used for the treatment of diabetic neuropathy.
Synthesis
5718-83-2
15174-47-7
82158-86-9
General procedure for the synthesis of the compound (CAS:82158-86-9) from 3-carboxymethyl bypassed tannin and trans-α-methyl cinnamaldehyde: Rhodanine-3-acetic acid (131.0 g) was dissolved in 700 mL of N,N-dimethylformamide (DMF), followed by a slow addition to the reaction mixture at 25-35°C of (E)-2-methyl-3-phenyl Acrolein (100.0 g) and 200 mL of DMF. next, a solution of ammonium acetate (63.27 g) dissolved in 60 mL of water was added to the reaction system, maintained at a temperature of 30-35°C and stirred for 4 hours. Upon completion of the reaction, the reaction mixture was cooled to 10-15°C. At this temperature, concentrated hydrochloric acid (100.0 g) was slowly added and the reaction temperature was maintained at 10-15°C for 2 hours. At the end of the reaction, the reaction mixture was filtered and the solid product was washed with DMF. Finally, the product was dried by rotary evaporation for 2-4 hours to give 2-((Z)-5-((E)-2-methyl-3-phenylpropenyl)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid in the yield of 260.50 g. The reaction was carried out at a temperature of 10-15°C for 2 hours.
References
[1] R KIKKAWA. Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235) on peripheral nerve disorders in streptozotocin-diabetic rats.[J]. Diabetologia, 1983, 24 4: 290-292. DOI:10.1007/bf00282716
[2] H TERASHIMA. Effects of a new aldose reductase inhibitor on various tissues in vitro.[J]. Journal of Pharmacology and Experimental Therapeutics, 1984, 229 1: 226-230.
[3] MARY ANN RAMIREZ Nancy L B. Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy.[J]. Pharmacotherapy, 2008, 28 5: 646-655. DOI:10.1592/phco.28.5.646
Epalrestat Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Epalrestat manufacturers
- Product
- Epalrestat 82159-09-9
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 100KGS
- Release date
- 2021-07-05
- Product
- Epalrestat 82159-09-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-13
- Product
- Epalrestat 82159-09-9
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-11-15