ChemicalBook > CAS DataBase List > Epalrestat

Epalrestat

Product Name
Epalrestat
CAS No.
82159-09-9
Chemical Name
Epalrestat
Synonyms
3-thiazolidineaceticacid,5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo;2-((Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid;e)-(e;Eabeth;Epatat;Ipastat;Epa－API;Kinedak;Epalrest;ONO 2235
CBNumber
CB6312501
Molecular Formula
C15H13NO3S2
Formula Weight
319.4
MOL File
82159-09-9.mol
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Epalrestat Property

Melting point:
210-217 C
Boiling point:
516.8±60.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble5mg/mL, clear (warmed)
pka
3.62±0.10(Predicted)
form 
powder
color 
yellow to orange
Merck 
14,3605
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChI
InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-
InChIKey
CHNUOJQWGUIOLD-NFZZJPOKSA-N
SMILES
S1/C(=C\C(\C)=C\C2=CC=CC=C2)/C(=O)N(CC(O)=O)C1=S
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Safety

RIDADR 
2811
WGK Germany 
3
RTECS 
XJ5131855
HS Code 
2932.99.7000
HazardClass 
6.1
PackingGroup 
II
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0527
Product name
Epalrestat
Purity
≥98% (HPLC)
Packaging
10mg
Price
$128
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0527
Product name
Epalrestat
Purity
≥98% (HPLC)
Packaging
50mg
Price
$496
Updated
2024/03/01
TCI Chemical
Product number
E0906
Product name
Epalrestat
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$135
Updated
2024/03/01
TCI Chemical
Product number
E0906
Product name
Epalrestat
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$337
Updated
2024/03/01
Cayman Chemical
Product number
15214
Product name
Epalrestat
Purity
≥98%
Packaging
5mg
Price
$73
Updated
2024/03/01
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Epalrestat Chemical Properties,Usage,Production

Description

Epalrestat is the second aldose reductase inhibitor to be introduced worldwide and the first to be launched in Japan. The compound is indicated for the treatment of diabetic neuropathy. It is also being investigated for diabetic retinopathy and nephropathy.

Chemical Properties

Red Solid

Originator

Ono (Japan)

Uses

Epalrestat has been used as an aldose reductase inhibitor:

  • in the dahomey larvae diet fed forDrosophila
  • for non-irradiated and X-ray irradiated human aldose reductase
  • to test its protective effect in mice with bleomycin-induced pulmonary fibrosis

Uses

Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM

Uses

An aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.

Definition

ChEBI: A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.

brand name

Kinedak

Biochem/physiol Actions

Epalrestat inhibits Aldose Reductase (AR) involved in the rate limiting step in the conversion of glucose to sorbitol under hyperglycemic conditions. Aldose reductase has been the target of multiple clinical investigatons to treat diabetic neuropathy and retinopathy. Epalrestat is an approved drug in Japan and India, used for the treatment of diabetic neuropathy.

References

1) Kikkawa?et al. (1983)?Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235), on peripheral nerve disorders in streptozotocin diabetic rats; Diabetologica,?24?290 2) Terashima?et al. (1984)?Effects of a new aldose reductase inhibitor on various tissues in vitro; J. Pharmacol. Exp. Ther.,?229?226 3) Ramirez and Borja (2008)?Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy; Pharmacotherapy,?28?646

Epalrestat Preparation Products And Raw materials

Raw materials

Concentrated hydrochloric acid Cinnamaldehyde Sodium glycinate Rhodanine-3-acetic acid 1,4-Dioxane Benzaldehyde Acetic acid Sodium chloroacetate

Preparation Products

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Epalrestat Suppliers

Americas 1 Belgium 1 Canada 2 China 344 Europe 4 Germany 6 India 41 Japan 4 Philippines 1 Switzerland 1 Turkey 1 Ukraine 1 United Arab Emirates 1 United Kingdom 12 United States 47 Global 467
Jiangxi Fanlai Biomedical Technology Co., Ltd.
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View Lastest Price from Epalrestat manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
Epalrestat 82159-09-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
10000ton
Release date
2024-04-24
Shanghai Joiny Pharmaceutical Co.,LTD
Product
(E,E)-2-[5-(2-Methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid 82159-09-9
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2024-03-12
Nantong Guangyuan Chemicl Co,Ltd
Product
Epalrestat 82159-09-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-11-01

82159-09-9, EpalrestatRelated Search:

2,2'-Dithiobis(benzothiazole) Triphenyltin acetate PHENYL VALERATE Fosthiazate Acetonitrile Methylparaben Methyl acrylate Methyl acetate Kresoxim-methyl Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Paraquat dichloride Basic Violet 1 Benzothiazole Methanol 1-Phenyl-2-nitropropene 4-oxo-2-mercapto-thiazole-3-acetic acid (intermediate of epalrestat) Brexpiprazole 4-oxo-5-[(2E)-3-phenyl-2-propen-1-ylidene]-2-thioxo-, (5Z)-

  • 3-thiazolidineaceticacid,5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo
  • 5-((1z,2e)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacet
  • e)-(e
  • EPALRESTAT
  • (e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid
  • AKOS BBS-00007767
  • OTAVA-BB BB7211260020
  • Epalrest
  • Epalrestat, 99.5%
  • Epa－API
  • Ipastat
  • EPALRESTAT(KINEDAK)
  • 5-[(1Z,2E)-2-METHYL-3-PHENYLPROPENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINEACETICACID(EPALRESTAT)
  • ONO 2235
  • Epalresta
  • 2-((E)-5-((E)-2-METHYL-3-PHENYLALLYLIDENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)ACETIC ACID
  • Epatrestat
  • 3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (E,E)-
  • 5-((1Z,2E)-2-Methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
  • [5-[(1Z,2E)-2-Methyl-3-phenylallylidene]-4-oxo-2-thioxothiazolidin-3-yl]acetic acid
  • Eabeth
  • Epatat
  • Quinedac
  • Kinedak
  • (E，E)-5-(2-Methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-3-thiazo-lidineaeetic acid
  • (5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic Acid
  • He IpaneMa Division
  • 2-[(5Z)-5[(E)-3-PHENIL-2-METHYLPROP-2-ENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINYL] ACETIC ACID
  • 2-((Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid
  • Epalrestat&gt
  • Epalrestat Epalrestat
  • Epalrestat RS
  • 3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-, (5Z)-
  • Epalrestat USP/EP/BP
  • Epalrestat (ONO2235)
  • EpalrestatQ: What is Epalrestat Q: What is the CAS Number of Epalrestat Q: What is the storage condition of Epalrestat Q: What are the applications of Epalrestat
  • According to Mr He
  • Antidiabetic API
  • Ipasetam
  • 82159-09-9
  • 81259-09-9
  • C15H13NO3S2
  • API
  • Hormone Drugs
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • API's
  • Treatment of diabetic neuropathy
  • 82159-09-9