Rhodanine-3-acetic acid

Product Name: Rhodanine-3-acetic acid
CAS No.: 5718-83-2
Chemical Name: Rhodanine-3-acetic acid
Synonyms: Epa－intB;AURORA 4784;AKOS B023269;AKOS BBS-00002149;TIMTEC-BB SBB003632;IFLAB-BB F1074-0188;Rhodanine acetic acid;OTAVA-BB BB0123270317;Rhodanine-3-aceticaci;rhodanine-n-acetic aci
CBNumber: CB4354093
Molecular Formula: C5H5NO3S2
Formula Weight: 191.23
MOL File: 5718-83-2.mol

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Rhodanine-3-acetic acid Property

Melting point:: 145-148 °C (lit.)
Boiling point:: 375.4±44.0 °C(Predicted)
Density: 1.492 (estimate)
refractive index: 1.5480 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: methanol: soluble25mg/mL, clear, yellow
form: solid
pka: 3.75±0.10(Predicted)
color: Off-White to Pale Beige
BRN: 149513
InChI: InChI=1S/C5H5NO3S2/c7-3-2-11-5(10)6(3)1-4(8)9/h1-2H2,(H,8,9)
InChIKey: JGRMXPSUZIYDRR-UHFFFAOYSA-N
SMILES: S1CC(=O)N(CC(O)=O)C1=S
CAS DataBase Reference: 5718-83-2(CAS DataBase Reference)
EPA Substance Registry System: 3-Thiazolidineacetic acid, 4-oxo-2-thioxo- (5718-83-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-41
Safety Statements: 26-36-39-25
WGK Germany: 3
F: 10-23
TSCA: Yes
HS Code: 29341000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 347558
Product name: 4-Oxo-2-thioxo-3-thiazolidinylacetic acid
Purity: ≥99%
Packaging: 5g
Price: $40.75
Updated: 2025/07/31

TCI Chemical

Product number: R0054
Product name: Rhodanine-3-acetic Acid
Purity: >98.0%(T)
Packaging: 5g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: R0054
Product name: Rhodanine-3-acetic Acid
Purity: >98.0%(T)
Packaging: 25g
Price: $51
Updated: 2025/07/31

Chem-Impex

Product number: 44142
Product name: Rhodanine-3-aceticacid,≥98%(Assaybytitration)
Purity: ≥98%(Assaybytitration)
Packaging: 25G
Price: $67.02
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H67-1-04
Product name: N-Carboxymethylrhodanine
Packaging: 5G
Price: $82
Updated: 2021/12/16

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Rhodanine-3-acetic acid Chemical Properties,Usage,Production

Chemical Properties

PALE YELLOW FINE CRYSTALINE POWDER

Uses

3-Rhodanineacetic Acid is an inhibitor for copper corrosion in acidic media.

Synthesis

75-15-0

3926-62-3

56-40-6

5718-83-2

GENERAL METHOD: Glycine (1 mol), 22% sodium hydroxide solution and carbon disulfide (1 mol) were dissolved in 3 mL of water and placed in a microwave reactor (CEM Discover, Benchmate, USA) and reacted at 100°C for 5 min. After the reaction was completed, it was automatically cooled to 40 °C, sodium chloroacetate (1 mol) was added and the mixture was again reacted at 100 °C for 5 min. The reaction solution was cooled to 40 °C and concentrated. To the concentrate, 3 mL of hydrochloric acid was added and the reaction was continued at 110°C for 20-30 minutes. Upon completion of the reaction, the crude product was extracted with ethyl acetate and purified (refer to Nitsche and Klein, 2012 method). The product obtained was 2-(4-oxo-2-thioxothiazolidin-3-yl)acetic acid (2a) in 82.5% yield; melting point 245-247 °C; UV λmax 266, 215 nm; IR (KBr) νmax 3439, 1663, 1512, 1321, 896 cm-1; 1H NMR (DMSO-d6, 400 MHz): δ= 4.56 (2H, s, N-CH2), 4.41 (2H, s, H-5); 13C NMR (DMSO-d6, 100 MHz): δ= 202.80 (C=S, C-2), 173.72 (C=O, COOH), 167.29 (C=O, C-4), 44.77 (CH2, N-CH2), 35.94 ( CH2, C-5); elemental analysis (C5H5NO3S2) calculated values: C, 31.40; H, 2.64; N, 7.32. measured values: C, 31.55; H, 2.53; N, 7.22.

References

[1] Archiv der Pharmazie, 2012, vol. 345, # 1, p. 73 - 80
[2] Medicinal Chemistry Research, 2016, vol. 25, # 5, p. 994 - 1004
[3] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 4, p. 359 - 364
[4] Patent: WO2010/24783, 2010, A1. Location in patent: Page/Page column 79; 80
[5] Archives of Pharmacal Research, 2014, vol. 37, # 7, p. 852 - 861

Rhodanine-3-acetic acid Preparation Products And Raw materials

Raw materials

Methyl thioglycolate Acetonitrile Ethanol N,N-Dimethylformamide Chlorotrimethylsilane Ammonium thiocyanate Ethyl bromoacetate Tetrahydrofuran Hydrochloric acid Bromoacetic acid Sodium hydroxide Tetrabutylammonium fluoride Potassium thiocyanate

Preparation Products

Epalrestat

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Rhodanine-3-acetic acid Suppliers

Austria 1 Belgium 1 Canada 1 China 238 France 1 Germany 11 India 8 Japan 4 Slovakia 1 Switzerland 2 The Netherlands 1 Ukraine 2 United Kingdom 18 United States 66 Global 355

Jiangxi Boya Seehot Pharmaceutical Co., Ltd.

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Jiangsu Hi-Pure Technology New Materials Co. Ltd.

Tel: 0512-62764072; 18051857768
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Wudi Reaction Pharma & Chemical Co.,ltd.

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Jiangxi taisinor Co., Ltd.

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Henan Vocas Biotechnology Co., Ltd

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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
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Ark Pharm, Inc.

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Energy Chemical

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Fax: 021-58436166
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Country: China
ProdList: 44801
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View Lastest Price from Rhodanine-3-acetic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Rhodanine-3-acetic acid 5718-83-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-27

Anhui Royal Chemical Co., Ltd.

Product: 3-CARBOXYMETHYL RHODANINE 5718-83-2
Price: US $4600.00/kg
Min. Order: 100kg
Purity: 99%
Supply Ability: 2 tons
Release date: 2024-05-23

Shaanxi Dideu Medichem Co. Ltd

Product: Rhodanine-3-acetic acid 5718-83-2
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-24

5718-83-2, Rhodanine-3-acetic acidRelated Search:

Carboxymethyl cellulose Sodium carboxymethyl cellulose Ethyl 2-(Chlorosulfonyl)acetate CARBOXYMETHYLCELLULOSE CALCIUM Sodium carboxyl methylstarch Folic acid Carboxymethyl chitosan Rhodanine Tannic acid Ascoric Acid EPROSARTAN Epalrestat iMpurity 4-(Hydroxymethyl)benzoic acid α-Methylcinnamaldehyde ethyl 2-((E)-5-((E)-2-methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetate (2-CHLORO-ACETYLAMINO)-ACETIC ACID METHYL ESTER 3-(2-THIENYL)PROPIONIC ACID Eprosartan related coMpound C

3-Thiazolidineacetic acid

Rhodanine acetic acid

Rhodanine-3-ethanoic acid

2-Thioxo-4-oxothiazolidine-3-acetic acid

Rhodanine-N-acetic acid,98%

RHODANINE-N-ACETIC ACID FOR SYNTHESIS

2-(4-Oxo-2-thioxothiazolidin-3-yl)acetic acid

N-(2-thioxo-4-oxothiazolidin)essigsure

TIMTEC-BB SBB003632

RHODANINE-N-ACETIC ACID

RHODANINE-3-ACETIC ACID

OTAVA-BB BB0123270317

N-CARBOXYMETHYLRHODANINE

AURORA 4784

CARBOXYMETHYL RHODANINE

IFLAB-BB F1074-0188

(4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL)ACETIC ACID

4-OXO-2-THIOXO-3-THIAZOLIDINEACETIC ACID

4-OXO-2-THIOXO-3-THIAZOLIDINYLACETIC ACID

(4-OXO-2-THIOXO-THIAZOLIDIN-3-YL)ACETIC ACID

2-THIOXO-4-THIAZOLIDINONE-N-ACETIC ACID

3-CarboxmethylRhadanine

4-oxo-2-thioxo-3-thiazolidineaceticaci

AKOS B023269

AKOS BBS-00002149

3-Carboxymethyl Rhodanine

RHODANINE-3-ACETIC ACID, 99+%

RHODANINE-3-ACETIC ACID 95%

Rhodanine-3-aceticacid,98%

3-Thiazolidineacetic acid, 4-oxo-2-thioxo-

3-Rhodanineacetic acid.

3-CARBOXMETHYL RHADANINE:RHODANINE-N-ACETIC ACID

N-CARBOXYMETHYLRHODANINE(RHODANINE-N-ACETICACID)

rhodanine-n-acetic aci

N-(2-thioxo-4-oxothiazolidine)aceticacid

2-Thioxo-4-thiazolidinone-3-acetic acid

3-CARBOXYMETHYL RHODANINE,ENTERPRISE STANDARD

Epa－intB

2-(4-oxo-3-thiazolidinyl)-2-sulfanylideneacetic acid

Rhodanine-3-acetic Acid &gt

Epalrestat Impurity 10 (Rhodanine-3-acetic Acid)

TIANFU CHEM Rhodanine-3-acetic acid

N-carboxymethyl diphine

4-Oxo-2-Thioxo-3-Thiazolidinyl Acetica Acid

N-Carboxymethylrhodanin

Rhodanine-3 cetic acid

Rhodanine-3-aceticaci

5718-83-2

C5H5NO3S2

C5H5O3NS2

C5H4NO3S2

Building Blocks

Thiazolines/Thiazolidines

Heterocyclic Building Blocks

Heterocycles

Acetics acid and esters

INTERMEDIATES