CARBOXYMETHYLCELLULOSE CALCIUM
- Product Name
- CARBOXYMETHYLCELLULOSE CALCIUM
- CAS No.
- 9050-04-8
- Chemical Name
- CARBOXYMETHYLCELLULOSE CALCIUM
- Synonyms
- D03400;ecg505;Ca-CMC;hylon600;CMCCalcium;calciumcm-cellulose;Carmellose calcium (jp15);calciumcelluloseglycolate;carboxyMethyl cellose calciuM;Calciam carboxymethylceUulose
- CBNumber
- CB8500399
- Molecular Formula
- C23H30ClN3O
- Formula Weight
- 399.9568
- MOL File
- 9050-04-8.mol
CARBOXYMETHYLCELLULOSE CALCIUM Property
- solubility
- Practically insoluble in acetone, chloroform, ethanol (95%), toluene, and ether. Insoluble in water, but swells to form a suspension.
- Major Application
- pharmaceutical (small molecule)
- Cosmetics Ingredients Functions
- FILM FORMING
VISCOSITY CONTROLLING
EMULSION STABILISING - InChI
- InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-14-17(24)9-11-21(19)26-22-12-10-18(28-4)15-20(22)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26)
- InChIKey
- SVUDQUZYHLUPQN-UHFFFAOYSA-N
- SMILES
- Clc1cc2c(nc3c(c2NC(CCCN(CC)CC)C)cc(cc3)OC)cc1
- EPA Substance Registry System
- Cellulose, carboxymethyl ether, calcium salt (9050-04-8)
Safety
- WGK Germany
- WGK 3
- TSCA
- TSCA listed
- HS Code
- 3912310000
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Resp. Sens. 1
Skin Sens. 1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
CARBOXYMETHYLCELLULOSE CALCIUM Chemical Properties,Usage,Production
Chemical Properties
DS 0.5-0.7
Chemical Properties
Carboxymethylcellulose calcium occurs as a white to yellowishwhite, hygroscopic, odorless powder.
Uses
Pharmaceutic aid (tablet disintegrant).
Production Methods
Cellulose, obtained from wood pulp or cotton fibers, is carboxymethylated, followed by conversion to the calcium salt. It is then graded on the basis of its degree of carboxymethylation and pulverized.
Pharmaceutical Applications
The main use of carboxymethylcellulose calcium is in tablet
formulations, where it is used as a binder, diluent,
and disintegrant. Although carboxymethylcellulose calcium is
insoluble in water, it is an effective tablet disintegrant as it swells to
several times its original bulk on contact with water. Concentrations
up to 15% w/w may be used in tablet formulations; above this
concentration, tablet hardness is reduced.
Carboxymethylcellulose calcium is also used in other applications
similarly to carboxymethylcellulose sodium; for example, as a
suspending or viscosity-increasing agent in oral and topical
pharmaceutical formulations. Carboxymethylcellulose calcium is
also used in modern wound dressings for its water absorption,
retention and hemostatic properties.
Safety
Carboxymethylcellulose calcium is used in oral and topical pharmaceutical formulations, similarly to carboxymethylcellulose sodium, and is generally regarded as a nontoxic and nonirritant material. However, as with other cellulose derivatives, oral consumption of large amounts of carboxymethylcellulose calcium may have a laxative effect.
storage
Carboxymethylcellulose calcium is a stable, though hygroscopic material. It should be stored in a well-closed container in a cool, dry place.
Regulatory Status
Included in the FDA Inactive Ingredients Database (oral, capsules and tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
CARBOXYMETHYLCELLULOSE CALCIUM Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CARBOXYMETHYLCELLULOSE CALCIUM manufacturers
- Product
- Carboxymethyl Cellulose Calcium 9050-04-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2024-04-08