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Tosylmethyl isocyanide

Product Name
Tosylmethyl isocyanide
CAS No.
36635-61-7
Chemical Name
Tosylmethyl isocyanide
Synonyms
TOSMIC;isocyanide;Tosylmethyl isocyani;LABOTEST-BB LT00159629;TOSYLMETHYL ISOCYANIDE;Tosylmethyleisocyanide;Tosylmethyl isocyanide,98%;Tosylmethy isocyanide ,98%;p-Toluenesulfonyl Isocyanide;TosMIC Tosylmethyl Isocyanide
CBNumber
CB5311774
Molecular Formula
C9H9NO2S
Formula Weight
195.24
MOL File
36635-61-7.mol
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Tosylmethyl isocyanide Property

Melting point:
109-113 °C(lit.)
Density 
1.2721 (rough estimate)
refractive index 
1.5270 (estimate)
storage temp. 
-20°C
solubility 
water: slightly soluble
form 
Liquid
color 
Clear
Water Solubility 
insoluble
Sensitive 
Moisture Sensitive
Merck 
14,9556
BRN 
3592382
InChIKey
BBNNLJMGPASZPD-UHFFFAOYSA-N
CAS DataBase Reference
36635-61-7(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi
Risk Statements 
23/24/25
Safety Statements 
36/37-45-38-36/37/39-28A
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
21
Hazard Note 
Irritant
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29299000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H311Toxic in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
188204
Product name
p-Toluenesulfonylmethyl isocyanide
Purity
98%
Packaging
5g
Price
$34.1
Updated
2021/03/22
Sigma-Aldrich
Product number
188204
Product name
p-Toluenesulfonylmethyl isocyanide
Purity
98%
Packaging
25g
Price
$140
Updated
2021/03/22
TCI Chemical
Product number
T1046
Product name
p-Toluenesulfonylmethyl Isocyanide
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$32
Updated
2021/03/22
TCI Chemical
Product number
T1046
Product name
p-Toluenesulfonylmethyl Isocyanide
Purity
>98.0%(HPLC)(N)
Packaging
25g
Price
$100
Updated
2021/03/22
Alfa Aesar
Product number
A14312
Product name
p-Toluenesulfonylmethyl isocyanide, 97%
Packaging
25g
Price
$123
Updated
2021/03/22
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Tosylmethyl isocyanide Chemical Properties,Usage,Production

Chemical Properties

Pale yellow to light brown crystalline powder

Uses

Reagent for use in the preparation of biologically active pyrroles and imidazoles.1,2

Uses

Tosylmethyl Isocyanide is used as a synthetic reagent in the preparation of variety or biologically active heterocycles such as pyrroles and imidazoles. Tosylmethyl Isocyanide is reported to inhibit [ Fe]-hydrogenase with very high affinity.

Uses

Versatile synthon in organic chemistry, especially in the synthesis of heterocyclic Compounds.

Preparation

N-(p-Tolylsulfonylmethyl)formamide 1609:

A 3-L, three-necked, round-bottomed flask, equipped with a mechanical stirrer, a condenser, and a thermometer, was charged with sodium p-toluenesulfinate 1606 (267 g, 1.5 mol). After the addition of water (750 mL), a 34–37% solution of formaldehyde 1607 (350 mL, 378 g, ca. 4.4 mol), formamide 1608 (600 mL, 680 g, 15 mol), and formic acid (200 mL, 244 g, 5.3 mol), the stirred reaction mixture was heated at 90 C°. The sodium p-toluenesulfinate dissolved during the heating, and the clear solution was kept at 90–95 C° for 2 h. It was then cooled in an ice/salt bath with continued stirring and further cooled overnight in a freezer at 20 C°. The white solid produced was collected by suction filtration. It was washed thoroughly in a beaker by stirring with three 250 mL portions of iced water. The product was dried under reduced pressure over phosphorus pentoxide at 70 C° to provide 134–150 g (42–47%) of crude N-(p-tolylsulfonylmethyl)formamide 1609; mp 106–110 C°. This product was sufficiently pure to be used directly in the following reaction.

Purification Methods

Use an efficient fume cupboard. Purify TOSMIC by dissolving (50g) in CH2Cl2 (150mL) and passing it through a column (40x3cm) containing neutral alumina (100g) in CH2Cl2 and eluting with CH2Cl2. A nearly colourless solution (700mL) is collected, evaporated in vacuo and the residue (42-47g) of TOSMIC (m 113-114o dec) is recrystallised once from MeOH (m 116-117o dec). [Hoogenboom et al. Org Synth 57 102 1977, Lensen Tetrahedron Lett 2367 1972.] It also crystallises from EtOH (charcoal) [Saito & Itano, J Chem Soc, Perkin Trans 1 1 1986].

Tosylmethyl isocyanide Preparation Products And Raw materials

Raw materials

Preparation Products

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Tosylmethyl isocyanide Suppliers

Synthetics China Co., Ltd.
Tel
0523-87980333-
Fax
0523- 87484111
Email
jerry.yu@synthetics-china.com
Country
China
ProdList
73
Advantage
60
Quzhou HuntBio Co., Ltd.
Tel
0571-64067827- ;0571-64067827-
Fax
0571-64067827
Email
sales@huntchem.com;sales@huntchem.com
Country
China
ProdList
225
Advantage
60
Finetech Industry Limited
Tel
027-87465837-
Fax
027-8777-2287
Email
sales@finetechnology-ind.com;
Country
China
ProdList
9374
Advantage
58
China fortune way company
Tel
010-84660735-
Email
rnd@sinopharmintl.com
Country
China
ProdList
22
Advantage
58
QINGDAO SYSTEMCHEM CO,.LTD.
Tel
532-15066846-6586;0532-66085265- ;
Fax
0532-66085265
Email
67306318@qq.com;linhuisicemo@163.com;2781949273@qq.com
Country
China
ProdList
86
Advantage
58
Creasyn Finechem(Tianjin) Co., Ltd.
Tel
022-83945878-
Fax
022-83945176
Email
export@creasyn.com
Country
China
ProdList
670
Advantage
68
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96500
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Beijing Donghualituo Techonlogy Development Co.,Ltd.
Tel
010-88425576
Fax
(+86)-10-88425546
Email
sales@dhltchem.com
Country
China
ProdList
794
Advantage
59
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3579
Advantage
66
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View Lastest Price from Tosylmethyl isocyanide manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Tosylmethyl isocyanide 36635-61-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Tosylmethyl isocyanide 36635-61-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08
Hebei Guanlang Biotechnology Co., Ltd.
Product
Tosylmethyl isocyanide 36635-61-7
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-06-01

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