ChemicalBook > CAS DataBase List > CARBOXYMETHYLCELLULOSE CALCIUM

CARBOXYMETHYLCELLULOSE CALCIUM

Product Name
CARBOXYMETHYLCELLULOSE CALCIUM
CAS No.
9050-04-8
Chemical Name
CARBOXYMETHYLCELLULOSE CALCIUM
Synonyms
D03400;ecg505;Ca-CMC;hylon600;CMCCalcium;calciumcm-cellulose;Carmellose calcium (jp15);calciumcelluloseglycolate;carboxyMethyl cellose calciuM;Calciam carboxymethylceUulose
CBNumber
CB8500399
Molecular Formula
C23H30ClN3O
Formula Weight
399.9568
MOL File
9050-04-8.mol
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CARBOXYMETHYLCELLULOSE CALCIUM Property

solubility 
Practically insoluble in acetone, chloroform, ethanol (95%), toluene, and ether. Insoluble in water, but swells to form a suspension.
EPA Substance Registry System
Cellulose, carboxymethyl ether, calcium salt (9050-04-8)
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Safety

HS Code 
3912310000
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Hazard and Precautionary Statements (GHS)

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CARBOXYMETHYLCELLULOSE CALCIUM Chemical Properties,Usage,Production

Chemical Properties

DS 0.5-0.7

Chemical Properties

Carboxymethylcellulose calcium occurs as a white to yellowishwhite, hygroscopic, odorless powder.

Uses

Pharmaceutic aid (tablet disintegrant).

Production Methods

Cellulose, obtained from wood pulp or cotton fibers, is carboxymethylated, followed by conversion to the calcium salt. It is then graded on the basis of its degree of carboxymethylation and pulverized.

Pharmaceutical Applications

The main use of carboxymethylcellulose calcium is in tablet formulations, where it is used as a binder, diluent, and disintegrant. Although carboxymethylcellulose calcium is insoluble in water, it is an effective tablet disintegrant as it swells to several times its original bulk on contact with water. Concentrations up to 15% w/w may be used in tablet formulations; above this concentration, tablet hardness is reduced.
Carboxymethylcellulose calcium is also used in other applications similarly to carboxymethylcellulose sodium; for example, as a suspending or viscosity-increasing agent in oral and topical pharmaceutical formulations. Carboxymethylcellulose calcium is also used in modern wound dressings for its water absorption, retention and hemostatic properties.

Safety

Carboxymethylcellulose calcium is used in oral and topical pharmaceutical formulations, similarly to carboxymethylcellulose sodium, and is generally regarded as a nontoxic and nonirritant material. However, as with other cellulose derivatives, oral consumption of large amounts of carboxymethylcellulose calcium may have a laxative effect.

storage

Carboxymethylcellulose calcium is a stable, though hygroscopic material. It should be stored in a well-closed container in a cool, dry place.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral, capsules and tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

CARBOXYMETHYLCELLULOSE CALCIUM Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CARBOXYMETHYLCELLULOSE CALCIUM manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Carboxymenthylcellulose Calcium Salt 9050-04-8
Price
US $0.01-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2020-04-21
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Carboxymethyl Cellulose Calcium 9050-04-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2024-04-08

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