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Methyl thioglycolate

Product Name
Methyl thioglycolate
CAS No.
2365-48-2
Chemical Name
Methyl thioglycolate
Synonyms
Methyl 2-mercaptoacetate;MTG;METHYL MERCAPTOACETATE;THIOGLYCOLIC ACID METHYL ESTER;MERCAPTOACETIC ACID METHYL ESTER;METG;usafek-7119;USAF ek-7119;Articaine-003;Methy Diglycolate
CBNumber
CB0165491
Molecular Formula
C3H6O2S
Formula Weight
106.14
MOL File
2365-48-2.mol
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Methyl thioglycolate Property

Melting point:
-24 °C
Boiling point:
42-43 °C/10 mmHg (lit.)
Density 
1.187 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.466(lit.)
Flash point:
86 °F
storage temp. 
Store below +30°C.
solubility 
40g/l
form 
Liquid
pka
8.04±0.10(Predicted)
color 
Clear colorless
Water Solubility 
40 g/L (20 ºC)
Sensitive 
Air Sensitive
BRN 
506259
InChIKey
MKIJJIMOAABWGF-UHFFFAOYSA-N
CAS DataBase Reference
2365-48-2(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, mercapto-, methyl ester(2365-48-2)
EPA Substance Registry System
Acetic acid, mercapto-, methyl ester (2365-48-2)
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Safety

Hazard Codes 
Xn,T
Risk Statements 
10-20/22-36/37/38-25
Safety Statements 
26-36/37-45-36/37/39-28A
RIDADR 
UN 1992 3/PG 3
WGK Germany 
1
RTECS 
AI7350000
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29309070
Hazardous Substances Data
2365-48-2(Hazardous Substances Data)
Toxicity
mouse,LD50,intraperitoneal,100mg/kg (100mg/kg),National Technical Information Service. Vol. AD277-689,
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
108995
Product name
Methyl thioglycolate
Purity
95%
Packaging
5g
Price
$36.4
Updated
2024/03/01
Sigma-Aldrich
Product number
108995
Product name
Methyl thioglycolate
Purity
95%
Packaging
100g
Price
$43.2
Updated
2024/03/01
TCI Chemical
Product number
T1287
Product name
Methyl Thioglycolate
Purity
>98.0%(GC)
Packaging
25g
Price
$25
Updated
2024/03/01
TCI Chemical
Product number
T1287
Product name
Methyl Thioglycolate
Purity
>98.0%(GC)
Packaging
100g
Price
$49
Updated
2024/03/01
Alfa Aesar
Product number
L03783
Product name
Methyl mercaptoacetate, 98%
Packaging
100g
Price
$29.65
Updated
2024/03/01
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Methyl thioglycolate Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

Methyl thioglycolate was used in the preparation of 3-carbomethoxy-4- oxotetrahydrothiopyran, 2- and 4-carbomethoxy-3-oxotetrahydrothiophene. It is used to prepare methyl thioglycolate and aminoethanethiol conjugated gold nanorods.

Uses

Methyl Thioglycolate is an derivative of Thioglycolic Acid (T350760), an organic compound containing both a thiol and a carboxylic acid functional groups. Thioglycolic Acid and its derivatives are oft en used in organic synthesis as a nucleophile in thioglycolysis reactions and is also used as a S transfer agent for sulfonyl chloride synthesis. Methyl Thioglycolate have been studied for the its inf luence on neocarzinostatin activation and expression of DNA damage.

Production Methods

Adding thioglycollic acid with purity of between 70.0 and 96.0 percent and methanol with purity of between 95.0 and 99.9 percent into a reaction device according to the molar ratio of 1:1.3-4.0; subsequently, adding an activating agent into the reaction device, stirring and heating for reaction; and after the reaction is finished, carrying out separatory distillation on reaction products to obtain the methyl thioglycolate. The activating agent is a p-toluenesulfonic acid methanol solution with a mass concentration of between 20 and 30 percent, and the use amount is 0.5 to 1.0 percent of the total mass of relative input materials.

Application

Methyl thioglycolate is a chemical compound that is used in the pharmaceutical industry as an intermediate. It has been used to synthesize anti-inflammatory drugs, such as aspirin and ibuprofen, and also for the treatment of autoimmune diseases. Methyl thioglycolate binds to amino acids on the surface of bacteria, which prevents them from functioning properly. This binding causes the cells to stop growing and die.

Definition

Methyl thioglycolate are widely used in free-radical photoinitiated polymerization reactions. In particular, the use of methyl thioglycolate (MTG), CH3OC(O)CH2SH, results in greater photopolymerization reaction rates, attributed to a weakening of the sulfur–hydrogen bond by hydrogen bonding of the thiol group. MTG constitutes the smaller exponent of the series of CH3OC(O)(CH2)nSH compounds, reported as intermediated in the organic sulfur cycle in marine environments, produced by marine phytoplankton.

General Description

Methyl thioglycolate reacts with nonprotein component of the antitumor antibiotic neocarzinostatin to form 1:1 adduct. It reacts with isothiocyanate to form Rhodanine.

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Methyl thioglycolate Suppliers

Qingdao ZKHT Chemical Co., Ltd.
Tel
532-86898076
Fax
86-532-86898076
Email
zkhtchem@163.com
Country
China
ProdList
30
Advantage
58
Qingdao RENAS Polymer Material Co.,Ltd.
Tel
0532-0532-86867058 18562606086
Fax
0532-86867058
Email
sales@qdrenas.com
Country
China
ProdList
128
Advantage
50
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2785118 17550508557
Fax
QQ:3470079902
Email
675141927@qq.com
Country
China
ProdList
3203
Advantage
55
Shanghai Guoyuan Chemical Co., Ltd.
Tel
0512-55170668 13913095008
Fax
0512-55170668
Email
shgyhg@139.com
Country
China
ProdList
585
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
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View Lastest Price from Methyl thioglycolate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Methyl thioglycolate 2365-48-2
Price
US $20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/Week
Release date
2024-05-06
Hebei Weibang Biotechnology Co., Ltd
Product
Methyl thioglycolate 2365-48-2
Price
US $100.00/KG
Min. Order
1KG
Purity
99.9%
Supply Ability
20 tons
Release date
2024-10-30
Hebei Weibang Biotechnology Co., Ltd
Product
Methyl thioglycolate 2365-48-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-30

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