Methyl 3-amino-4-phenylthiophene-2-carboxylate

Product Name: Methyl 3-amino-4-phenylthiophene-2-carboxylate
CAS No.: 82437-64-7
Chemical Name: Methyl 3-amino-4-phenylthiophene-2-carboxylate
Synonyms: Methyl 3-amino-4-phenylthiophene-2-carboxylate;Methyl 3-amino-4-phenylthiophene-2-carboxylate ,98%;3-Amino-4-phenyl-2-thiophenecarboxylic acid methyl ester;2-Thiophenecarboxylic acid, 3-amino-4-phenyl-, methyl ester;JR-8062, Methyl 3-amino-4-phenylthiophene-2-carboxylate, 97%
CBNumber: CB2501682
Molecular Formula: C12H11NO2S
Formula Weight: 233.29
MOL File: 82437-64-7.mol

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Methyl 3-amino-4-phenylthiophene-2-carboxylate Property

Melting point:: 69 °C
Density: 1.265
storage temp.: 2-8°C(protect from light)
form: solid
InChI: InChI=1S/C12H11NO2S/c1-15-12(14)11-10(13)9(7-16-11)8-5-3-2-4-6-8/h2-7H,13H2,1H3
InChIKey: UKWKMKNACSKDCN-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)SC=C(C2=CC=CC=C2)C=1N

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 24/25
WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: JRD0490
Product name: Methyl 3-amino-4-phenylthiophene-2-carboxylate
Purity: Aldrich
Packaging: 1g
Price: $185
Updated: 2025/07/31

AK Scientific

Product number: 2746AC
Product name: Methyl 3-amino-4-phenylthiophene-2-carboxylate
Packaging: 250mg
Price: $198
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1047501
Product name: Methyl 3-amino-4-phenylthiophene-2-carboxylate
Purity: 95.00%
Packaging: 5G
Price: $1091.48
Updated: 2021/12/16

Arctom

Product number: AS025707
Product name: Methyl 3-amino-4-phenylthiophene-2-carboxylate
Purity: ≥95%
Packaging: 100mg
Price: $21
Updated: 2021/12/16

Ambeed

Product number: A127585
Product name: Methyl 3-amino-4-phenylthiophene-2-carboxylate
Purity: 95+%
Packaging: 100mg
Price: $23
Updated: 2021/12/16

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Methyl 3-amino-4-phenylthiophene-2-carboxylate Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Synthesis

73591-08-9

2365-48-2

82437-64-7

GENERAL STEPS: Sodium methanolate (5 M methanol solution, 3.5 mL, 17.6 mmol) and methyl mercaptoacetate (1.8 mL, 20.1 mmol) were added sequentially to 3-methoxy-2-phenylacrylonitrile (2 g, 12.6 mmol). The reaction mixture was stirred and refluxed at 65 °C overnight. After completion of the reaction, the mixture was filtered using diatomaceous earth and the filter cake was washed with dichloromethane. The crude product was purified by column chromatography (silica gel, n-hexane: ethyl acetate = 5:1) to afford the white solid product methyl 3-amino-4-phenylthiophene-2-carboxylate (1.5 g, 6.6 mmol, 52% yield in two steps). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.49-7.39 (m, 5H), 7.25 (s, 1H), 5.64 (br, 2H), 3.88 (s, 3H).

References

[1] Bulletin of the Korean Chemical Society, 2015, vol. 36, # 5, p. 1439 - 1451
[2] Patent: US2014/228565, 2014, A1. Location in patent: Paragraph 0197; 0198
[3] European Journal of Medicinal Chemistry, 2014, vol. 85, p. 629 - 637

Methyl 3-amino-4-phenylthiophene-2-carboxylate Preparation Products And Raw materials

Raw materials

Methyl thioglycolate N,N-Dimethylformamide Ethyl formate Sodium Benzeneacetonitrile Tosyl chloride Methanol

Preparation Products

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Methyl 3-amino-4-phenylthiophene-2-carboxylate Suppliers

China 27 India 3 United Kingdom 2 United States 9 Global 41

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JR-8062, Methyl 3-amino-4-phenylthiophene-2-carboxylate, 97%

3-Amino-4-phenyl-2-thiophenecarboxylic acid methyl ester

Methyl 3-amino-4-phenylthiophene-2-carboxylate

Methyl 3-amino-4-phenylthiophene-2-carboxylate ,98%

2-Thiophenecarboxylic acid, 3-amino-4-phenyl-, methyl ester

82437-64-7