Methyl 3-amino-4-phenylthiophene-2-carboxylate
- Product Name
- Methyl 3-amino-4-phenylthiophene-2-carboxylate
- CAS No.
- 82437-64-7
- Chemical Name
- Methyl 3-amino-4-phenylthiophene-2-carboxylate
- Synonyms
- Methyl 3-amino-4-phenylthiophene-2-carboxylate;Methyl 3-amino-4-phenylthiophene-2-carboxylate ,98%;3-Amino-4-phenyl-2-thiophenecarboxylic acid methyl ester;2-Thiophenecarboxylic acid, 3-amino-4-phenyl-, methyl ester;JR-8062, Methyl 3-amino-4-phenylthiophene-2-carboxylate, 97%
- CBNumber
- CB2501682
- Molecular Formula
- C12H11NO2S
- Formula Weight
- 233.29
- MOL File
- 82437-64-7.mol
Methyl 3-amino-4-phenylthiophene-2-carboxylate Property
- Melting point:
- 69 °C
- Density
- 1.265
- storage temp.
- 2-8°C(protect from light)
- form
- solid
- InChI
- InChI=1S/C12H11NO2S/c1-15-12(14)11-10(13)9(7-16-11)8-5-3-2-4-6-8/h2-7H,13H2,1H3
- InChIKey
- UKWKMKNACSKDCN-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)SC=C(C2=CC=CC=C2)C=1N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- JRD0490
- Product name
- Methyl 3-amino-4-phenylthiophene-2-carboxylate
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $185
- Updated
- 2025/07/31
- Product number
- 2746AC
- Product name
- Methyl 3-amino-4-phenylthiophene-2-carboxylate
- Packaging
- 250mg
- Price
- $198
- Updated
- 2021/12/16
- Product number
- CHM1047501
- Product name
- Methyl 3-amino-4-phenylthiophene-2-carboxylate
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1091.48
- Updated
- 2021/12/16
- Product number
- CD41000341
- Product name
- Methyl 3-amino-4-phenylthiophene-2-carboxylate
- Purity
- 95+%
- Packaging
- 25g
- Price
- $1188
- Updated
- 2021/12/16
- Product number
- JR-8062
- Product name
- Methyl 3-amino-4-phenylthiophene-2-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $371
- Updated
- 2021/12/16
Methyl 3-amino-4-phenylthiophene-2-carboxylate Chemical Properties,Usage,Production
Chemical Properties
Light yellow solid
Synthesis
73591-08-9
2365-48-2
82437-64-7
GENERAL STEPS: Sodium methanolate (5 M methanol solution, 3.5 mL, 17.6 mmol) and methyl mercaptoacetate (1.8 mL, 20.1 mmol) were added sequentially to 3-methoxy-2-phenylacrylonitrile (2 g, 12.6 mmol). The reaction mixture was stirred and refluxed at 65 °C overnight. After completion of the reaction, the mixture was filtered using diatomaceous earth and the filter cake was washed with dichloromethane. The crude product was purified by column chromatography (silica gel, n-hexane: ethyl acetate = 5:1) to afford the white solid product methyl 3-amino-4-phenylthiophene-2-carboxylate (1.5 g, 6.6 mmol, 52% yield in two steps). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.49-7.39 (m, 5H), 7.25 (s, 1H), 5.64 (br, 2H), 3.88 (s, 3H).
References
[1] Bulletin of the Korean Chemical Society, 2015, vol. 36, # 5, p. 1439 - 1451
[2] Patent: US2014/228565, 2014, A1. Location in patent: Paragraph 0197; 0198
[3] European Journal of Medicinal Chemistry, 2014, vol. 85, p. 629 - 637
Methyl 3-amino-4-phenylthiophene-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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