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Methyl 3-amino-4-methylthiophene-2-carboxylate

Product Name
Methyl 3-amino-4-methylthiophene-2-carboxylate
CAS No.
85006-31-1
Chemical Name
Methyl 3-amino-4-methylthiophene-2-carboxylate
Synonyms
3-AMINO-4-METHYL-2-THIOPHENECARBOXYLIC ACID METHYL ESTER;3-Amino Articaine;3-AMINO-4-METHYLTHIOPHENECARBOXYLIC ACID METHYL ESTER;M3A4MT2C;Articaine-002;Articaine Impurity I;Articaine Impurity 9;LABOTEST-BB LT00453517;Articaine EP Impurity I;Articaine intermediate E
CBNumber
CB0189112
Molecular Formula
C7H9NO2S
Formula Weight
171.22
MOL File
85006-31-1.mol
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Methyl 3-amino-4-methylthiophene-2-carboxylate Property

Melting point:
85-88 °C (lit.)
Boiling point:
318.6±37.0 °C(Predicted)
Density 
1.264±0.06 g/cm3(Predicted)
Flash point:
>100°C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
1.71±0.10(Predicted)
form 
Solid
color 
Pale Yellow
Water Solubility 
1g/L at 35℃
BRN 
973196
InChI
1S/C7H9NO2S/c1-4-3-11-6(5(4)8)7(9)10-2/h3H,8H2,1-2H3
InChIKey
YICRPERKKBDRSP-UHFFFAOYSA-N
SMILES
COC(=O)c1scc(C)c1N
LogP
1.28
CAS DataBase Reference
85006-31-1(CAS DataBase Reference)
NIST Chemistry Reference
Methyl 3-amino-4-methylthiophene-2-carboxylate(85006-31-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25-22
WGK Germany 
2
Hazard Note 
Irritant
HS Code 
29349990
Storage Class
11 - Combustible Solids
Hazard Classifications
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
546658
Product name
Methyl 3-amino-4-methylthiophene-2-carboxylate
Purity
97%
Packaging
5g
Price
$14.25
Updated
2025/07/31
Sigma-Aldrich
Product number
PHR9159
Product name
Methyl 3-amino-4-methylthiophene-2-carboxylate
Purity
certified reference material, <I>Trace</I><B>CERT</B><SUP>&#174;</SUP>, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
Packaging
100 mg
Price
$825
Updated
2025/07/31
Sigma-Aldrich
Product number
546658
Product name
Methyl 3-amino-4-methylthiophene-2-carboxylate
Purity
97%
Packaging
25g
Price
$103.55
Updated
2025/07/31
TCI Chemical
Product number
M1772
Product name
Methyl 3-Amino-4-methylthiophene-2-carboxylate
Purity
>98.0%(GC)
Packaging
5g
Price
$29
Updated
2025/07/31
TCI Chemical
Product number
M1772
Product name
Methyl 3-Amino-4-methylthiophene-2-carboxylate
Purity
>98.0%(GC)
Packaging
25g
Price
$100
Updated
2025/07/31
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Methyl 3-amino-4-methylthiophene-2-carboxylate Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

Methyl 3-Amino-4-methylthiophene-2-carboxylate is a versatile reactant used in various syntheses. It is used in the preparation of (oxalylamino)benzoic acids and (carboxyheteroarylamino)oxalic acids as selective and orally bioavailable nonpeptide inhibitors of protein-tyrosine phosphatase 1B.

Application

methyl 3-amino-4-methylthiophene-2-carboxylate is the starting material used in the synthesis of the local anesthetic articaine.
7-Methylthieno[3,2-d]pyrimidin-4(3H)-one was prepared using methyl 3-amino-4-methylthiophene-2-carboxylate.
The reaction of 4-bromotoluene (0.171 g, 1 mmol), methyl 3-amino-4-methylthiophene-2-carboxylate(0.342 g, 2 mmol) and KOAc (0.196 g, 2 mmol) in the presence of PdCl(C3H5)(dppb) (12.2 mg, 0.02mmol) in DMAc at 120 °C affords the corresponding Methyl 3-amino-4-methyl-5-p-tolylthiophene-2-carboxylate in 81% (0.212 g) isolated yield.

Definition

ChEBI: Methyl 3-amino-4-methylthiophene-2-carboxylate is a thiophenecarboxylic acid.

Methyl 3-amino-4-methylthiophene-2-carboxylate Preparation Products And Raw materials

Raw materials

Methyl thioglycolate Sodium hydride Ethanol Hydroxylamine hydrochloride Methyl methacrylate

Preparation Products

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Methyl 3-amino-4-methylthiophene-2-carboxylate Suppliers

Americas 1 Belgium 1 China 311 Europe 3 France 4 Germany 8 India 20 Italy 2 Japan 2 Slovakia 3 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 17 United States 43 Global 419
Suqian Gaosai Biomedical Technology Co., Ltd
Tel
15250728346
Email
465418843@qq.com
Country
China
ProdList
29
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58
Wuhan EnTai Technology Development Co,.Ltd
Tel
86-27-82330560
Fax
86-27-82330547
Email
2536851935@qq.com
Country
China
ProdList
347
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69
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
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66
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
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65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
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84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
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61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
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56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
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66
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View Lastest Price from Methyl 3-amino-4-methylthiophene-2-carboxylate manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
Methyl 3-amino-4-methylthiophene-2-carboxylate 85006-31-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2025-09-22
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Methyl 3-amino-4-methylthiophene-2-carboxylate 85006-31-1
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min HPLC
Supply Ability
1000kgs
Release date
2021-07-16
Hebei Fengjia New Material Co., Ltd
Product
Methyl 3-amino-4-methylthiophene-2-carboxylate 85006-31-1
Price
US $5.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2024-08-16

85006-31-1, Methyl 3-amino-4-methylthiophene-2-carboxylateRelated Search:

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