ChemicalBook > CAS DataBase List > 4-Chlorothieno[3,2-d]pyrimidine

4-Chlorothieno[3,2-d]pyrimidine

Product Name
4-Chlorothieno[3,2-d]pyrimidine
CAS No.
16269-66-2
Chemical Name
4-Chlorothieno[3,2-d]pyrimidine
Synonyms
KML-21;CML-006;4-chlorothieno[3;BUTTPARK 37\11-73;BUTTPARK 48\18-41;4-Chlorothieno[3,2-d]pyri...;4-CHLOROTHIENO[3,2-D]PYRIMIDINE;4-CHLOROTHIENO[2,3-D]PYRIMIDINE;4-Chlorothieno[3,2-b]pyrimidine;Thieno[3,2-d]pyrimidine, 4-chloro-
CBNumber
CB9119316
Molecular Formula
C6H3ClN2S
Formula Weight
170.62
MOL File
16269-66-2.mol
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4-Chlorothieno[3,2-d]pyrimidine Property

Melting point:
125 °C
Boiling point:
285.7±20.0 °C(Predicted)
Density 
1.531±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
crystalline powder
pka
0.54±0.40(Predicted)
color 
Yellow
CAS DataBase Reference
16269-66-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn,T
Risk Statements 
22-36/37/38-36-25
Safety Statements 
26-37/39-45
RIDADR 
UN2811
HazardClass 
IRRITANT
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
C364483
Product name
4-Chlorothieno[3,2-d]pyrimidine
Packaging
50mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC140199
Product name
4-Chlorothieno[3,2-d]pyrimidine
Packaging
10g
Price
$87.5
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0023662
Product name
4-CHLOROTHIENO[3,2-D]PYRIMIDINE
Purity
95.00%
Packaging
1G
Price
$140.7
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC140199
Product name
4-Chlorothieno[3,2-d]pyrimidine
Packaging
25g
Price
$176
Updated
2021/12/16
SynQuest Laboratories
Product number
7H70-5-W5
Product name
4-Chlorothieno[3,2-d]pyrimidine
Packaging
25g
Price
$229
Updated
2021/12/16
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4-Chlorothieno[3,2-d]pyrimidine Chemical Properties,Usage,Production

Synthesis

16234-10-9

16269-66-2

The general procedure for the synthesis of 4-chlorothieno[3,2-d]pyrimidine using thieno[3,2-d]pyrimidin-4(3H)-one as starting material was as follows: dimethylformamide (15.4 mL, 197.13 mmol) was added to 150 mL of dichloroethane and the reaction system was cooled down to 0 °C. Subsequently, oxalyl chloride (25 mL, 295.70 mmol) was added slowly and dropwise. After the formation of a white gel-like substance was observed, 3H-thieno[3,2-d]pyrimidin-4-one (15 g, 98.57 mmol) was added. The reaction mixture was stirred at 0 °C for 2.5 h and then gradually warmed up to room temperature. Upon completion of the reaction, the reaction was quenched by the addition of water and the organic layer was extracted with dichloromethane (3 x 300 mL), the organic phases were combined and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the residue was ground with 200 mL of hexane to afford 4-chlorothieno[3,2-d]pyrimidine (16.7 g, 99% yield) as a dark brown solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 9.06 (s, 1H), 8.61 (d, J = 5.2 Hz, 1H), 7.78 (d, J = 5.2 Hz, 1H); LC-MS showed the molecular ion peak m/z 173.2 ([MH]+).

References

[1] Patent: US2013/72482, 2013, A1. Location in patent: Paragraph 0211; 0216; 0217
[2] Patent: WO2005/51304, 2005, A2. Location in patent: Page/Page column 67-68
[3] Patent: WO2005/51304, 2005, A2. Location in patent: Page/Page column 67-68
[4] Patent: WO2006/10264, 2006, A1. Location in patent: Page/Page column 51; 67-68
[5] MedChemComm, 2015, vol. 6, # 2, p. 339 - 346

4-Chlorothieno[3,2-d]pyrimidine Preparation Products And Raw materials

Raw materials

Methyl thioglycolate Ethyl Thioglycolate 2-Chloro-3-cyanopyridine Ethanol 2-Chloroacrylonitrile Triethyl orthoformate Sodium Phosphorus oxitrichloride Sodium ethoxide Methanol Ammonium acetate Sodium carbonate

Preparation Products

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4-Chlorothieno[3,2-d]pyrimidine Suppliers

Belgium 1 Canada 2 China 174 Germany 2 India 1 Ukraine 1 United Kingdom 10 United States 27 Global 218
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
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69
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
Tel
21-57721279
Fax
QQ：14057904
Email
sales@shydchem.com.cn
Country
China
ProdList
998
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56
Shangchem Co., Ltd.
Tel
+86-21-68182121
Fax
+86-21-68182121
Country
China
ProdList
882
Advantage
52
Suzhou Zehou Biotechnology Co. , Ltd.
Tel
0512-68716880 19984816880
Fax
18075373931
Email
sales@growingchem.com
Country
China
ProdList
212
Advantage
64
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
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62
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View Lastest Price from 4-Chlorothieno[3,2-d]pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-Chlorothieno[3,2-d]pyrimidine 16269-66-2
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-12
R&D Scientific Inc.
Product
4-Chlorothieno[3,2-d]pyrimidine 16269-66-2
Price
US $520.00/g
Min. Order
1g
Purity
98
Supply Ability
500 Kg
Release date
2024-02-19
Career Henan Chemical Co
Product
4-Chlorothieno[3,2-d]pyrimidine 16269-66-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-06-21

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