6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE
- Product Name
- 6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE
- CAS No.
- 56844-12-3
- Chemical Name
- 6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE
- Synonyms
- 6-broMo-4-chlorothieno[2;6-bromo-4-chlorothie[2,3-d]pyrimidine;6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE;Thieno[2,3-d]pyrimidine, 6-bromo-4-chloro-;4-Chloro-6-bromothiopheno [2,3-d] pyrimidine;6-bromo-4-chlorothiophene [2, 3-d] pyrimidine;6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE ISO 9001：2015 REACH
- CBNumber
- CB91478485
- Molecular Formula
- C6H2BrClN2S
- Formula Weight
- 249.52
- MOL File
- 56844-12-3.mol
6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE Property
- Boiling point:
- 345.5±37.0 °C(Predicted)
- Density
- 1.955±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -0.34±0.40(Predicted)
- Appearance
- White to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B684888
- Product name
- 6-Bromo-4-chlorothieno[2,3-d]pyrimidine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B684888
- Product name
- 6-Bromo-4-chlorothieno[2,3-d]pyrimidine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB148743
- Product name
- 6-Bromo-4-chlorothieno[2,3-d]pyrimidine
- Packaging
- 25mg
- Price
- $67
- Updated
- 2021/12/16
- Product number
- FB148743
- Product name
- 6-Bromo-4-chlorothieno[2,3-d]pyrimidine
- Packaging
- 50mg
- Price
- $117
- Updated
- 2021/12/16
- Product number
- 7H70-D-05
- Product name
- 6-Bromo-4-chlorothieno[2,3-d]pyrimidine
- Packaging
- 1g
- Price
- $134
- Updated
- 2021/12/16
6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE Chemical Properties,Usage,Production
Synthesis
56844-40-7
56844-12-3
General procedure for the synthesis of 4-chloro-6-bromothieno[2,3-d]pyrimidin-4(3H)-one from 6-bromothieno[2,3-d]pyrimidin-4(3H)-one: 6-bromothieno[2,3-d]pyrimidin-4(3H)-one (32.7 g, 142 mmol) was mixed with phosphorus triclosan (100 mL) and heated to reflux for 3 hours at 120 °C. Upon completion of the reaction, the reaction mixture was quenched by slowly pouring it into a mixture containing 5 M aqueous sodium hydroxide solution (1 L) and ice. Subsequently, the pH was adjusted with saturated aqueous sodium bicarbonate solution to 7. The precipitate formed was collected by filtration and washed with distilled water (3 x 200 mL). Drying gave 4-chloro-6-bromothieno[2,3-d]pyrimidine (31.0 g, 124 mmol, 88% yield) as a brown solid with a melting point of 112-118°C. Part of the product was further purified by silica gel column chromatography: the dried product was loaded onto the top of a pre-populated silica gel column and eluted with dichloromethane as the eluent, and the melting point of the purified product was 114-118 °C; the Rf value of thin-layer chromatography (dichloromethane/methanol, 98/2) was 0.67; 1H NMR (400 MHz, DMSO-d6) δ: 8.95 (s, 1H), and 7.89 (s, 1H); 13C NMR (100 MHz, DMSO-d6) δ: 168.9,153.2,152.5,130.2,122.9,118.5; infrared spectra (pure sample, cm-1): 3082,1508,1411,959,832,816,760; high-resolution mass spectrometry (EI, 70eV m/z): 247.8813 (calculated value C6H2BrClN2S, 247.8811, M+).1H NMR spectrum is in agreement with the literature41.13C NMR spectral data and reference melting point were not determined.
References
[1] Chemical Communications, 2017, vol. 53, # 32, p. 4473 - 4476
[2] Tetrahedron, 2012, vol. 68, # 45, p. 9226 - 9233
[3] MedChemComm, 2015, vol. 6, # 2, p. 339 - 346
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5522 - 5537
[5] Patent: WO2012/44993, 2012, A1. Location in patent: Page/Page column 44-45
6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE Preparation Products And Raw materials
Raw materials
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View Lastest Price from 6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE manufacturers
- Product
- 6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE 56844-12-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-01
- Product
- 6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE 56844-12-3
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g； 1kg; 25kg
- Release date
- 2020-01-10
- Product
- 6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE 56844-12-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-02