ChemicalBook > CAS DataBase List > 6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE

6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE

Product Name
6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE
CAS No.
56844-12-3
Chemical Name
6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE
Synonyms
6-broMo-4-chlorothieno[2;6-bromo-4-chlorothie[2,3-d]pyrimidine;6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE;Thieno[2,3-d]pyrimidine, 6-bromo-4-chloro-;4-Chloro-6-bromothiopheno [2,3-d] pyrimidine;6-bromo-4-chlorothiophene [2, 3-d] pyrimidine;6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE ISO 9001：2015 REACH
CBNumber
CB91478485
Molecular Formula
C6H2BrClN2S
Formula Weight
249.52
MOL File
56844-12-3.mol
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6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE Property

Boiling point:
345.5±37.0 °C(Predicted)
Density 
1.955±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
-0.34±0.40(Predicted)
Appearance
White to yellow Solid
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B684888
Product name
6-Bromo-4-chlorothieno[2,3-d]pyrimidine
Packaging
250mg
Price
$55
Updated
2021/12/16
TRC
Product number
B684888
Product name
6-Bromo-4-chlorothieno[2,3-d]pyrimidine
Packaging
500mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148743
Product name
6-Bromo-4-chlorothieno[2,3-d]pyrimidine
Packaging
25mg
Price
$67
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148743
Product name
6-Bromo-4-chlorothieno[2,3-d]pyrimidine
Packaging
50mg
Price
$117
Updated
2021/12/16
SynQuest Laboratories
Product number
7H70-D-05
Product name
6-Bromo-4-chlorothieno[2,3-d]pyrimidine
Packaging
1g
Price
$134
Updated
2021/12/16
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6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE Chemical Properties,Usage,Production

Synthesis

56844-40-7

56844-12-3

General procedure for the synthesis of 4-chloro-6-bromothieno[2,3-d]pyrimidin-4(3H)-one from 6-bromothieno[2,3-d]pyrimidin-4(3H)-one: 6-bromothieno[2,3-d]pyrimidin-4(3H)-one (32.7 g, 142 mmol) was mixed with phosphorus triclosan (100 mL) and heated to reflux for 3 hours at 120 °C. Upon completion of the reaction, the reaction mixture was quenched by slowly pouring it into a mixture containing 5 M aqueous sodium hydroxide solution (1 L) and ice. Subsequently, the pH was adjusted with saturated aqueous sodium bicarbonate solution to 7. The precipitate formed was collected by filtration and washed with distilled water (3 x 200 mL). Drying gave 4-chloro-6-bromothieno[2,3-d]pyrimidine (31.0 g, 124 mmol, 88% yield) as a brown solid with a melting point of 112-118°C. Part of the product was further purified by silica gel column chromatography: the dried product was loaded onto the top of a pre-populated silica gel column and eluted with dichloromethane as the eluent, and the melting point of the purified product was 114-118 °C; the Rf value of thin-layer chromatography (dichloromethane/methanol, 98/2) was 0.67; 1H NMR (400 MHz, DMSO-d6) δ: 8.95 (s, 1H), and 7.89 (s, 1H); 13C NMR (100 MHz, DMSO-d6) δ: 168.9,153.2,152.5,130.2,122.9,118.5; infrared spectra (pure sample, cm-1): 3082,1508,1411,959,832,816,760; high-resolution mass spectrometry (EI, 70eV m/z): 247.8813 (calculated value C6H2BrClN2S, 247.8811, M+).1H NMR spectrum is in agreement with the literature41.13C NMR spectral data and reference melting point were not determined.

References

[1] Chemical Communications, 2017, vol. 53, # 32, p. 4473 - 4476
[2] Tetrahedron, 2012, vol. 68, # 45, p. 9226 - 9233
[3] MedChemComm, 2015, vol. 6, # 2, p. 339 - 346
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5522 - 5537
[5] Patent: WO2012/44993, 2012, A1. Location in patent: Page/Page column 44-45

6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE Suppliers

China 101 Germany 2 India 1 United Kingdom 1 United States 15 Global 120
NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
Advantage
58
ACTIVATE SCIENTIFIC GmbH
Tel
--
Fax
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Email
info@activate-scientific.com
Country
Germany
ProdList
2856
Advantage
61
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View Lastest Price from 6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE manufacturers

Dideu Industries Group Limited
Product
6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE 56844-12-3
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-01
Career Henan Chemical Co
Product
6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE 56844-12-3
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
500g； 1kg; 25kg
Release date
2020-01-10
Career Henan Chemical Co
Product
6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE 56844-12-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-02

56844-12-3, 6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINERelated Search:

4-CHLOROTHIENO[2,3-D]PYRIMIDINE 6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE

  • 6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE
  • 6-broMo-4-chlorothieno[2
  • 6-bromo-4-chlorothie[2,3-d]pyrimidine
  • Thieno[2,3-d]pyrimidine, 6-bromo-4-chloro-
  • 6-BROMO-4-CHLOROTHIENO[2,3-D]PYRIMIDINE ISO 9001：2015 REACH
  • 4-Chloro-6-bromothiopheno [2,3-d] pyrimidine
  • 6-bromo-4-chlorothiophene [2, 3-d] pyrimidine
  • 56844-12-3
  • pyrimidine
  • Heterocycle-Pyrimidine series
  • CHIRAL CHEMICALS