4,6-Dichloropyrimidine
Uses- Product Name
- 4,6-Dichloropyrimidine
- CAS No.
- 1193-21-1
- Chemical Name
- 4,6-Dichloropyrimidine
- Synonyms
- NSC 37530;4,6-DichL;DichloropyriMidine;IFLAB-BB F2124-0077;4,6-Dichloropyrimidi;4,6-Dichloropyridine;4,6-Dichlorpyrimidin;4,6-Dichoropyrimidine;4,6-DICHLOROPYRIMIDINE;4,6-Dichloro-1,3-diazine
- CBNumber
- CB6473590
- Molecular Formula
- C4H2Cl2N2
- Formula Weight
- 148.98
- MOL File
- 1193-21-1.mol
4,6-Dichloropyrimidine Property
- Melting point:
- 65-67 °C (lit.)
- Boiling point:
- 176 °C (lit.)
- Density
- 1.6445 (rough estimate)
- vapor pressure
- 30-390Pa at 20-50℃
- refractive index
- 1.6300 (estimate)
- Flash point:
- 176°C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- 95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow
- form
- Crystals
- pka
- -4.20±0.17(Predicted)
- color
- Yellow-green
- BRN
- 111195
- InChIKey
- XJPZKYIHCLDXST-UHFFFAOYSA-N
- LogP
- 1.45 at 25℃ and pH7.2
- Surface tension
- 65.72mN/m at 1g/L and 20℃
- CAS DataBase Reference
- 1193-21-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Pyrimidine, 4,6-dichloro-(1193-21-1)
Safety
- Hazard Codes
- C
- Risk Statements
- 34-20/21/22-36/37
- Safety Statements
- 26-36/37/39-45-27
- RIDADR
- UN 3263 8/PG 2
- WGK Germany
- 3
- F
- 19
- Hazard Note
- Corrosive
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 145378
- Product name
- 4,6-Dichloropyrimidine
- Purity
- 97%
- Packaging
- 10g
- Price
- $91.3
- Updated
- 2024/03/01
- Product number
- 145378
- Product name
- 4,6-Dichloropyrimidine
- Purity
- 97%
- Packaging
- 50g
- Price
- $126.8
- Updated
- 2024/03/01
- Product number
- D2488
- Product name
- 4,6-Dichloropyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $16
- Updated
- 2024/03/01
- Product number
- D2488
- Product name
- 4,6-Dichloropyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $44
- Updated
- 2024/03/01
- Product number
- L13212
- Product name
- 4,6-Dichloropyrimidine, 98%
- Packaging
- 25g
- Price
- $133.65
- Updated
- 2024/03/01
4,6-Dichloropyrimidine Chemical Properties,Usage,Production
Uses
4,6-Dichloropyrimidine (cas# 1193-21-1) is a compound useful in organic synthesis.
Chemical Properties
Yellow Solid
Uses
4,6-Dichloropyrimidine was used in the synthesis of N-substituted azacalix[4]pyrimidines. It was used as starting reagent for the synthesis of disubstituted pyrimidines by tandem amination and Suzuki-Miyaura cross-coupling. It was also used in a biarylpyrimidine synthesis involving biaryl cross-coupling.
General Description
Cyclic voltammograms of 4,6-dichloropyrimidine shows three cathodic waves, arising from sequential cleavage of carbon-chlorine bonds as well as the reduction of pyrimidine.
Synthesis
The synthesis of 4,6-Dichloropyrimidine is as follows:Dissolve 105.5g of 4,6-diaminopyrimidine in 660.0g of 31% hydrochloric acid and pour into a 2000ml bottle to cool to -5 ° C and dropwise add 500.3g of 33% sodium nitrite. After 2 hours of reaction, HPLC detects 4,6-diamino Pyrimidine is less than 0.5%. 42.8 g of cuprous chloride and 214.0 g of 31% hydrochloric acid are prepared in a 2000 ml bottle. The diazonium salt mother liquor is added dropwise to the bottle. After the dropwise reaction, the reaction is performed at 45 ° C for 2 hours. .Extract with 400g of recovered trichloroethane (200x2 times less than new ones), combine the organic layers for distillation, control the water flush pump 5KPa, temperature 40-140 , collect 404.2g of solvent in the early 40-90 , 90-140 in the later The product was collected at a temperature of 14 ° C to obtain 146.9 g of 4,6-dichloropyrimidine. The yield was 86.4% (based on formazan hydrochloride) and the purity was 99.4%.
4,6-Dichloropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,6-Dichloropyrimidine manufacturers
- Product
- 4,6-Dichloropyrimidine 1193-21-1
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 1000KGS
- Release date
- 2021-06-28
- Product
- 4,6-dichloropyrimidine 1193-21-1
- Price
- US $140.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 2000 KG
- Release date
- 2023-01-06
- Product
- 4,6-Dichloropyrimidine 1193-21-1
- Price
- US $1.50/g
- Min. Order
- 1g
- Purity
- 99.0% Min
- Supply Ability
- 100 Tons
- Release date
- 2022-09-19