6-Chloropyrimidin-4(3H)-one

Product Name: 6-Chloropyrimidin-4(3H)-one
CAS No.: 4765-77-9
Chemical Name: 6-Chloropyrimidin-4(3H)-one
Synonyms: NSC 618279;6-Chlorpyrimidin-4-ol;6-Chloro-4-pyrimidinol;6-CHLOROPYRIMIDIN-4-OL;4-Chloropyrimidin-6-one;6-chloropyriMidine-4-ol;6-CHLOROPYRIMIDIN-4(3H)-ONE;6-Chloro-4(1H)-Pyrimidinone;6-chloro-4(3H)-Pyrimidinone;6-chloropyrimidin-4(1H)-one
CBNumber: CB8853660
Molecular Formula: C4H3ClN2O
Formula Weight: 130.53
MOL File: 4765-77-9.mol

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6-Chloropyrimidin-4(3H)-one Property

Melting point:: 194 °C
Boiling point:: 199.4±50.0 °C(Predicted)
Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO, Water
form: Solid
pka: 6.92±0.40(Predicted)
color: Off-White to Pale Yellowish
CAS DataBase Reference: 4765-77-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-41-37/38-22
Safety Statements: 22-26-36/37/39-39
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2368
Product name: 4-Chloro-6-hydroxypyrimidine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $34
Updated: 2025/07/31

TCI Chemical

Product number: C2368
Product name: 4-Chloro-6-hydroxypyrimidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $132
Updated: 2025/07/31

TRC

Product number: C366670
Product name: 4-Chloro-6-hydroxypyrimidine
Packaging: 5g
Price: $65
Updated: 2021/12/16

Usbiological

Product number: C5010-37
Product name: 4-Chloro-6-hydroxypyrimidine
Packaging: 1g
Price: $403
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0025189
Product name: 6-CHLORO-4-HYDROXYPYRIMIDINE
Purity: 95.00%
Packaging: 1G
Price: $779.78
Updated: 2021/12/16

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6-Chloropyrimidin-4(3H)-one Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Yellowish Solid

Uses

4-Chloro-6-hydroxypyrimidine (cas# 4765-77-9) is a compound useful in organic synthesis.

Definition

ChEBI: 6-Chloro-4-pyrimidinol is an organohalogen compound and a member of pyrimidines.

Synthesis

1193-21-1

4765-77-9

The general procedure for the synthesis of 6-chloropyrimidin-4(3H)-ones from 4,6-dichloropyrimidines is as follows: Intermediate 1: Synthesis of 6-chloro-3H-pyrimidin-4-one 4,6-Dichloropyrimidine (Aldrich; 10.00 g, 67.1 mmol), concentrated hydrochloric acid (50 mL), water (50 mL), and dioxane (50 mL) were mixed and heated at 70 °C for 6 h, and subsequently cooled to room temperature to obtain a pink solution. The solvent was removed by evaporation under reduced pressure (using a vacuum pump) to obtain a pink solid. Ethanol (50 mL) was added to the solid and the mixture was heated until the solid was completely dissolved. The solution was cooled slowly in a warm water bath at about 50°C. After standing overnight, it was filtered to obtain an off-white solid, 6-chloro-3H-pyrimidin-4-one (5.02 g, 57% yield), with a melting point of 193-194°C (literature value: 192-193°C, see DJ Brown and JS Harper, J. Chem. Soc. 1961, 1298-1303). 1H NMR (d6-DMSO) data: δ 6.50 (s, 1H), 8.19 (s, 1H), 13.00 (br s, 1H).

References

[1] Journal of the Chinese Chemical Society, 2013, vol. 60, # 1, p. 27 - 34
[2] Patent: US2009/149466, 2009, A1
[3] Patent: WO2017/59080, 2017, A1. Location in patent: Page/Page column 288; 289

6-Chloropyrimidin-4(3H)-one Preparation Products And Raw materials

Raw materials

4,6-Dichloropyrimidine Ethyl acetate Hydrochloric acid Diisopropyl ether Ammonia

Preparation Products

ETRIMFOS

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6-Chloropyrimidin-4(3H)-one Suppliers

Americas 1 Belgium 1 Canada 1 China 141 Europe 2 Germany 2 India 7 Japan 1 The Netherlands 1 United Kingdom 8 United States 22 Global 187

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View Lastest Price from 6-Chloropyrimidin-4(3H)-one manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Chloro-6-hydroxypyriMidine 4765-77-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-14

Career Henan Chemical Co

Product: 6-Chloropyrimidin-4(3H)-one 4765-77-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500kg
Release date: 2018-08-19

4765-77-9, 6-Chloropyrimidin-4(3H)-oneRelated Search:

Trazodone Chlormezanone 3'-Chloroacetophenone Chlortalidone 6-CHLORO-2,4-DIMETHOXYPYRIMIDINE 2,4-Dichloro-6-methoxypyrimidine 2-AMINO-4-CHLORO-6-ETHOXYPYRIMIDINE 2-Amino-4-chloro-6-methoxypyrimidine Difluorochloromethane KETAMINE/ZYLAZINE SOLUTION--SCHEDULE*III ITEM 4-chloro-6-methoxy-2-methylpyrimidin-5-amine 2-AMINO-6-CHLORO-4-PYRIMIDINOL HYDRATE, 95 6-Chlorouracil Moxonidine 2-Amino-6-chloro-4-pyrimidinol (6-CHLOROPYRIDAZIN-3-YL)(PHENYL)METHANONE 4-Hydroxypyrimidine Chlorimuron-ethyl

6-CHLOROPYRIMIDIN-4(3H)-ONE

6-CHLOROPYRIMIDIN-4-OL

6-Chloro-4-pyrimidinol

6-CHLORO-4-HYDROXYPYRIMIDINE

4(1H)-Pyrimidinone, 6-chloro- (9CI)

6-Chloro-4(1H)-Pyrimidinone

6-CHLORO-4-HYDROXYPYRIMIDINE,98%

6-chloropyrimidin-4(1H)-one

4-Chloropyrimidin-6-one

6-chloro-4(3H)-Pyrimidinone

NSC 618279

4(1H)-Pyrimidinone, 6-chloro-

6-Chloro-3,4-dihydro-4-oxopyrimidine

4-hydroxy-6-chloropyriMidine

6-Chloro-4-pyrimidinol 6-Chloro-4(1H)-pyrimidinone

6-chloropyriMidine-4-ol

4-CHLORO-6-HYDROXYPYRIMIDINE

6-Chloro-1,4-dihydropyrimidin-4-one

4-Chloro-6-hydroxypyrimidine &gt

6-Chlorpyrimidin-4-ol

4765-77-9

765-77-9

Bases & Related Reagents

Nucleotides

Heterocycle-Pyrimidine series

Heterocycles

Nucleotides and Nucleosides

PYRIMIDINE

APIs & Intermediate