ChemicalBook > CAS DataBase List > 2-Amino-4-chloro-6-methoxypyrimidine

2-Amino-4-chloro-6-methoxypyrimidine

Product Name
2-Amino-4-chloro-6-methoxypyrimidine
CAS No.
5734-64-5
Chemical Name
2-Amino-4-chloro-6-methoxypyrimidine
Synonyms
ACMP;2-Pyrimidinamine, 4-chloro-6-methoxy-;TIMTEC-BB SBB003975;2-amino-4-chloro-6-methoxypyri;2-Amino-4-methoxy-6-chloropyri;4-chloro-6-methoxy-2-pyrimidinamin;2-AMino-4-chloro-6-MethylyriMidine;4-Chloro-6-methoxy-2-pyrimidinamine;2-amino-4-chloro-6-methoxypyrimidne;4-methoxy-6-chloro-2-aminopyrimidine
CBNumber
CB4707363
Molecular Formula
C5H6ClN3O
Formula Weight
159.57
MOL File
5734-64-5.mol
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2-Amino-4-chloro-6-methoxypyrimidine Property

Melting point:
168-171 °C (lit.)
Boiling point:
349.4±45.0 °C(Predicted)
Density 
1.6625 (rough estimate)
refractive index 
1.4510 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
1.96±0.10(Predicted)
form 
Crystalline Powder
color 
Light yellow
CAS DataBase Reference
5734-64-5(CAS DataBase Reference)
EPA Substance Registry System
2-Pyrimidinamine, 4-chloro-6-methoxy- (5734-64-5)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
22-2
WGK Germany 
1
RTECS 
UV6260335
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
518646
Product name
2-Amino-4-chloro-6-methoxypyrimidine
Purity
95%
Packaging
10g
Price
$55.9
Updated
2023/06/20
Sigma-Aldrich
Product number
518646
Product name
2-Amino-4-chloro-6-methoxypyrimidine
Purity
95%
Packaging
50g
Price
$164
Updated
2023/06/20
TCI Chemical
Product number
A1520
Product name
2-Amino-4-chloro-6-methoxypyrimidine
Purity
>95.0%(HPLC)(T)
Packaging
5g
Price
$21
Updated
2025/07/31
TCI Chemical
Product number
A1520
Product name
2-Amino-4-chloro-6-methoxypyrimidine
Purity
>95.0%(HPLC)(T)
Packaging
25g
Price
$23
Updated
2025/07/31
Usbiological
Product number
295304
Product name
2-Amino-6-chloro-4-methoxypyrimidine
Packaging
5g
Price
$275
Updated
2021/12/16
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2-Amino-4-chloro-6-methoxypyrimidine Chemical Properties,Usage,Production

Chemical Properties

light yellow crystalline powder

Uses

2-Amino-4-chloro-6-methoxy-pyrimidine is one of the two major metabolites formed in the degradation of chlorimuron-ethyl; a pre- and post-emergence herbicide for the control of important broad-leaved weeds in soybean and maize.

Synthesis

67-56-1

56-05-3

5734-64-5

GENERAL PROCEDURE: Intermediate Id-f was prepared similarly to Intermediate Ia-c. Anhydrous tetrahydrofuran (12 mL) solution of sodium hydride (5.8 mmol) was cooled to 0 °C under nitrogen protection, followed by slow dropwise addition of substitutional alcohol (6.1 mmol). The reaction mixture was kept stirred at 0 °C for 15 min. Then, 2-amino-4,6-dichloropyrimidine (5.8 mmol) was added to the reaction system. The reaction temperature was raised to 62°C and the reaction was continued for 15 hours. After completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched with 1 M hydrochloric acid solution (1 mL). The reaction mixture was diluted with ethyl acetate (20 mL), washed twice sequentially with saturated sodium bicarbonate solution (20 mL) and brine (20 mL), and the organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether as eluent) to afford the target compound Id-f. 4-Chloro-6-methoxypyrimidin-2-amine (Id) was a white solid with a melting point of 165-167 °C in 84% yield.1H-NMR (CDCl3) δ 6.04 (s, 1H, ArH), 5.35-5.14 (m, 2H , NH2), 3.81 (s, 3H, OCH3).

References

[1] Patent: WO2004/37795, 2004, A1. Location in patent: Page/Page column 8
[2] ACS Medicinal Chemistry Letters, 2011, vol. 2, # 10, p. 774 - 779
[3] Molecules, 2018, vol. 23, # 9,
[4] Nippon Kagaku Zasshi, 1953, vol. 74, p. 624
[5] Chem.Abstr., 1954, p. 13693

2-Amino-4-chloro-6-methoxypyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-4-chloro-6-methoxypyrimidine Suppliers

Americas 1 Belgium 1 Canada 1 China 262 Europe 3 France 1 Germany 7 India 10 Japan 3 Russia 1 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 20 United States 49 Global 365
J & K SCIENTIFIC LTD.
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View Lastest Price from 2-Amino-4-chloro-6-methoxypyrimidine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Amino-4-chloro-6-methoxypyrimidine 5734-64-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-28
Shaanxi Dideu Medichem Co. Ltd
Product
2-Amino-4-chloro-6-methoxypyrimidine 5734-64-5
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-13
Career Henan Chemical Co
Product
2-Amino-4-chloro-6-methoxypyrimidine 5734-64-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-08-20

5734-64-5, 2-Amino-4-chloro-6-methoxypyrimidineRelated Search:

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  • C5H6N3OCl
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  • Building Blocks
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  • Halogenated Heterocycles
  • Heterocycle-Pyrimidine series
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • PyrimidinesHeterocyclic Building Blocks
  • Pyrimidines
  • Pyrimidine
  • Pyridines, Pyrimidines, Purines and Pteredines