2-Amino-4-chloropyrimidine

Product Name: 2-Amino-4-chloropyrimidine
CAS No.: 3993-78-0
Chemical Name: 2-Amino-4-chloropyrimidine
Synonyms: 4-CHLOROPYRIMIDIN-2-AMINE;NSC 10872;NSC 25184;AKOS BBS-00005838;CHLORO-ISO-CYTOSINE;2-Amino-4-chloropyri;2-Amino-4-chlor-pyrimidin;4-Chloro-2-pyrimidinamine;2-Amino-4-chlorpyrimidine;4-Chloropyrimidine-2-amine
CBNumber: CB5184107
Molecular Formula: C4H4ClN3
Formula Weight: 129.55
MOL File: 3993-78-0.mol

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2-Amino-4-chloropyrimidine Property

Melting point:: 155-160 °C (dec.)
Boiling point:: 314.6±34.0 °C(Predicted)
Density: 1.437±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in dimethyl sulfoxide.
pka: 3.55±0.10(Predicted)
form: Solid
color: White
InChI: InChI=1S/C4H4ClN3/c5-3-1-2-7-4(6)8-3/h1-2H,(H2,6,7,8)
InChIKey: DBGFGNCFYUNXLD-UHFFFAOYSA-N
SMILES: C1(N)=NC=CC(Cl)=N1
CAS DataBase Reference: 3993-78-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-41-37/38-22
Safety Statements: 26-36/37/39-36/39-60
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 661325
Product name: 2-Amino-4-chloropyrimidine
Purity: 97%
Packaging: 1g
Price: $11.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 661325
Product name: 2-Amino-4-chloropyrimidine
Purity: 97%
Packaging: 5g
Price: $70.85
Updated: 2025/07/31

TCI Chemical

Product number: A2150
Product name: 4-Chloropyrimidin-2-amine
Packaging: 1G
Price: $51
Updated: 2025/07/31

TCI Chemical

Product number: A2150
Product name: 4-Chloropyrimidin-2-amine
Packaging: 10G
Price: $216
Updated: 2025/07/31

Usbiological

Product number: A1376-66
Product name: 2-Amino-4-chloropyrimidine
Packaging: 1g
Price: $333
Updated: 2021/12/16

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2-Amino-4-chloropyrimidine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

2-Amino-4-chloropyrimidine is a substrate used in a palladium-catalyzed cyanation with zinc(II) cyanide. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

Synthesis

3934-20-1

7461-50-9

3993-78-0

2,4-Dichloropyrimidine (1.0 g, 6.7 mmol) was used as starting material and 28% w/v aqueous ammonium hydroxide solution (20 mL) was added. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure. The obtained residue was dried and subsequently purified by fast column chromatography (FCC) with the eluent being chloroform solution containing 2-10% ethanol, resulting in the isolation of 2-amino-4-chloropyrimidine and 2-chloro-4-aminopyrimidine. Product yields: 200 mg of 2-amino-4-chloropyrimidine in 23% yield and 600 mg of 2-chloro-4-aminopyrimidine in 69% yield.

Purification Methods

It has also been purified by sublimation in a vacuum and recrystrallisation from H2O. [Hilbert & Johnson J Am Chem Soc 52 1155 1930, Beilstein 24 H 80, 25 III/IV 2117.]

References

[1] Patent: WO2010/20556, 2010, A1. Location in patent: Page/Page column 62
[2] Journal of the American Chemical Society, 2003, vol. 125, # 33, p. 9970 - 9982
[3] Tetrahedron, 2010, vol. 66, # 6, p. 1280 - 1288
[4] Patent: WO2006/114409, 2006, A1. Location in patent: Page/Page column 18
[5] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 14, p. 1973 - 1978

2-Amino-4-chloropyrimidine Preparation Products And Raw materials

Raw materials

Phosphorus oxitrichloride Chlorosulfonic acid Isocytosine

Preparation Products

2-AMINO-4-METHOXYPYRIMIDINE

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2-Amino-4-chloropyrimidine Suppliers

Canada 1 China 287 Europe 2 France 1 Germany 3 India 9 Japan 1 Russia 1 Switzerland 2 The Netherlands 1 United Kingdom 17 United States 39 Global 364

Nanjing the parson's chemical technology co., LTD

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ITIC MEDCHEM(SUZHOU) CO.,LTD.

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View Lastest Price from 2-Amino-4-chloropyrimidine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Amino-4-chloropyrimidine 3993-78-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-07-05

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-Amino-4-chloropyrimidine 3993-78-0
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-11-12

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Amino-4-chloropyrimidine 3993-78-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

3993-78-0, 2-Amino-4-chloropyrimidineRelated Search:

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AKOS BBS-00005838

4-CHLOROPYRIMIDIN-2-AMINE

2-PYRIMIDINAMINE, 4-CHLORO-

2-AMINO-4-CHLOROPYRIMIDINE

CHLORO-ISO-CYTOSINE

2-Pyrimidinamine, 4-chloro- (9CI)

2-AMINO-4-CHLOROPYRIMIDINE, 98+%

2-Amino-4-chloropyri

4-Chloropyrimidin-2-amine, 2-Amino-4-chloro-1,3-diazine

2-Amino-4-chlor-pyrimidin

4-Chloropyrimidine-2-amine

2-Amino-4-chloropyrimidin...

2-AMino-4-chloropyriMidine/4-AMino-2-chloropyriMidine

4-chloropyrimidin-2-amine3993-78-0

2-AMINO-4-CHLOROPYRIMIDINE(WX900081)

2-amine-4-chloropyrimidine

4-Chloro-pyrimidin-2-ylamine

4-Chloro-2-pyrimidinamine

NSC 10872

NSC 25184

2-amino-4-chloridepyrimidine

2-amino-4-chloropyrimidein

4-chloro-pyrimidine-2-ylamine

2-Amino-4-chlorpyrimidine

3-Furancarboxylicacid,5-(chlorosulfonyl)-4-methyl-,methylester

2-Amino-4-Chloropyrimidine CAS NO.: 3993-78-0

3993-78-0

C4H2ClN3

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyrimidines

Building Blocks

Bases & Related Reagents

Heterocycles

Nucleotides

Pyrazines, Pyrimidines & Pyridazines

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrimidines

PyrimidinesHeterocyclic Building Blocks

Heterocycle-Pyrimidine series

Amines

Pyrazines, Pyrimidines & Pyridazines

Heterocyclic Compounds

chloropyrimidin

PYRIMIDINE

APIs & Intermediate

Pyridines, Pyrimidines, Purines and Pteredines