2-Amino-6-chloropurine Riboside
- Product Name
- 2-Amino-6-chloropurine Riboside
- CAS No.
- 2004-07-1
- Chemical Name
- 2-Amino-6-chloropurine Riboside
- Synonyms
- 6-Cl-Gr;NSC 44586;2-Amino-6-chL;6-CHLOROADENOSINE;6-CHLOROGUANOSINE;6-Chloroguanosine2;oropurine riboside;Regadenoson Impurity 40;6-CHLOROGUANINE RIBOSIDE;2-NH2-6-Cl-purine-riboside
- CBNumber
- CB1755136
- Molecular Formula
- C10H12ClN5O4
- Formula Weight
- 301.69
- MOL File
- 2004-07-1.mol
2-Amino-6-chloropurine Riboside Property
- Melting point:
- 165-167 °C (dec.)(lit.)
- Boiling point:
- 729.9±70.0 °C(Predicted)
- Density
- 1.8359 (rough estimate)
- refractive index
- -38 ° (C=0.1, H2O)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO, Methanol
- form
- Powder
- pka
- 13.05±0.70(Predicted)
- color
- White to Off-white
- InChIKey
- TXWHPSZYRUHEGT-ACJOCUEISA-N
- CAS DataBase Reference
- 2004-07-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 24/25-36-26
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A2054
- Product name
- 2-Amino-6-chloropurine Riboside
- Purity
- >95.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $50
- Updated
- 2024/03/01
- Product number
- A2054
- Product name
- 2-Amino-6-chloropurine Riboside
- Purity
- >95.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $196
- Updated
- 2024/03/01
- Product number
- J64468
- Product name
- 2-Amino-6-chloropurine riboside, 95%
- Packaging
- 1g
- Price
- $99.65
- Updated
- 2024/03/01
- Product number
- J64468
- Product name
- 2-Amino-6-chloropurine riboside, 95%
- Packaging
- 5g
- Price
- $191
- Updated
- 2021/12/16
- Product number
- A1376-58
- Product name
- 2-Amino-6-chloropurine-9-b-D-riboside
- Packaging
- 500mg
- Price
- $319
- Updated
- 2021/12/16
2-Amino-6-chloropurine Riboside Chemical Properties,Usage,Production
Chemical Properties
Colourless Crystalline Solid
Uses
2-Amino-6-chloropurine riboside (1) is a a novel class of inhibitors of endogenous protein degradation for the preparation of a number of important purine nucleoside derivatives. For example, 6-thioguanosine 2 and 6-selenoguanosine 3 were prepared from a reaction of 1 and the corresponding sodium thiosulfate or potassium selenosulfate.1) 18O-labeled guanosine 4 was incubated from 1 with adenosine deaminase in (18O)-water.2) 2-Amino-6-ethoxypurine riboside 5 and 2-amino-N6-amino-N6-methyladenosine 6 were prepared by treatment of 1 with nucleophiles, sodium ethoxide and methylhydrazine, respectively.3,4) 2-Amino-N6-substituted purine analogues, as typified by 6, were reported as anti-malarial active compounds.
References
[1] A. JANKOWSKI L. T D Wise. Sodium Thiosulfate and Potassium Selenosulfate as Reagents to Prepare Thio-and Selenopurine Nucleosides[J]. Nucleosides, Nucleotides & Nucleic Acids, 1989, 8 1: 339-348. DOI:10.1080/07328318908054179.
[2] SUNDEEP RAYAT. 5-Cyanoimino-4-oxomethylene-4,5-dihydroimidazole and 5-Cyanoamino-4-imidazolecarboxylic Acid Intermediates in Nitrosative Guanosine Deamination: Evidence from 18O-Labeling Experiments[J]. Journal of the American Chemical Society, 2004, 126 32: 9960-9969. DOI:10.1021/ja049835q.
[3] MORRIS J. ROBINS. Nucleic acid related compounds. 114. Synthesis of 2,6-(disubstituted)purine 2′,3′-dideoxynucleosides and selected cytotoxic, anti-hepatitis b, and adenosine deaminase substrate activities[J]. Journal of Heterocyclic Chemistry, 2009, 38 6: 1297-1306. DOI:10.1002/jhet.5570380609.
[4] KATHLEEN TOO . Anti-malarial activity of N6-modified purine analogues[J]. Bioorganic & Medicinal Chemistry, 2007, 15 16: Pages 5551-5562. DOI:10.1016/j.bmc.2007.05.038.
[5] ALICJA STACHELSKA-WIERZCHOWSKA. Tri-Cyclic Nucleobase Analogs and their Ribosides as Substrates of Purine-Nucleoside Phosphorylases. II Guanine and Isoguanine Derivatives.[J]. Molecules, 2019, 24 8. DOI:10.3390/molecules24081493.
[6] SHIH-HSI CHU Ming Y C Chyng Yann Shiue. Synthesis and cytotoxicity of 6-selenopurine arabinoside and related compounds[J]. Journal of pharmaceutical sciences, 1975, 64 8: 1343-1346. DOI:10.1002/jps.2600640818.
2-Amino-6-chloropurine Riboside Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-6-chloropurine Riboside manufacturers
- Product
- 2-Amino-6-chloropurine-9-riboside 2004-07-1
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 500kg
- Release date
- 2021-12-09
- Product
- 2-Amino-6-chloropurine-9-riboside 2004-07-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-22
- Product
- 2-Amino-6-chloropurine-9-riboside 2004-07-1
- Price
- US $0.00/G/KG
- Min. Order
- 1G/KG
- Purity
- 99%
- Supply Ability
- 100000000KG
- Release date
- 2025-02-12