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Guanosine

Description Reference
Product Name
Guanosine
CAS No.
118-00-3
Chemical Name
Guanosine
Synonyms
GR;2-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one;VERNINE;2-AMINO-9-BETA-D-RIBOFURANOSYL-9H-PURINE-6-(1H)-ONE;2-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one;Guo;GCCR;Guanozin;uanosine;GUANOSINE
CBNumber
CB2701721
Molecular Formula
C10H13N5O5
Formula Weight
283.24
MOL File
118-00-3.mol
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Guanosine Property

Melting point:
250 °C (dec.) (lit.)
alpha 
-62 º (c=3, in 0.1 N NaOH)
Boiling point:
425.8°C (rough estimate)
Density 
1.3790 (rough estimate)
refractive index 
-76 ° (C=1, 1mol/L NaOH)
storage temp. 
room temp
solubility 
0.1 M NaOH: 0.1 g/mL, clear, slightly yellow
pka
pK1:1.9(+1);pK2:9.25(0);pK3:12.33(OH) (25°C)
form 
Powder
color 
White to light yellow
Odor
Odorless
optical activity
[α]20/D -73±2°, c = 1.5% in 1 M NaOH
Water Solubility 
0.75 g/L (25 ºC)
Merck 
14,4566
BRN 
625911
InChIKey
NYHBQMYGNKIUIF-UUOKFMHZSA-N
LogP
-2.331 (est)
CAS DataBase Reference
118-00-3(CAS DataBase Reference)
NIST Chemistry Reference
guanosine(118-00-3)
EPA Substance Registry System
Guanosine (118-00-3)
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Safety

Hazard Codes 
T,Xi
Risk Statements 
25
Safety Statements 
45-24/25-23
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
MF8750000
10-23
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
75903
Product name
Guanosine
Purity
≥97.0% (HPLC)
Packaging
100g
Price
$294
Updated
2024/03/01
Sigma-Aldrich
Product number
75903
Product name
Guanosine
Purity
≥97.0% (HPLC)
Packaging
500g
Price
$1140
Updated
2023/06/20
TCI Chemical
Product number
G0171
Product name
Guanosine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$19
Updated
2024/03/01
TCI Chemical
Product number
G0171
Product name
Guanosine
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$36
Updated
2024/03/01
Alfa Aesar
Product number
A11328
Product name
Guanosine, 98+%
Packaging
25g
Price
$56.4
Updated
2024/03/01
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Guanosine Chemical Properties,Usage,Production

Description

Guanosine is a purine nucleoside, in which the guanine attached to the C1 carbon of a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Its phosphorylated derivatives include GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP (guanosine diphosphate), and GTP (guanosine triphosphate). These guanosine derivatives are very important in various biochemical processes, such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction, and intracellular signal transduction.
Guanosine is thought to have neuroprotective properties. It can reduce neuroinflammation, oxidative stress, and excitotoxicity, as well as exerting trophic effects in neuronal and glial cells. It is shown to be protective in central nervous system diseases including ischemic stroke, Alzheimer’s disease, Parkinson’s disease, spinal cord injury, nociception, and depression. Guanosine is found to be associated with purine nucleoside phosphorylase (PNP) deficiency, which is an inborn error of metabolism.

Reference

L. E. B. Bettio, J. Gil-Mohapel, A. L. S. Rodrigues, Guanosine and its role in neurophathologies, Purinergic Signal, 2016, vol. 12, pp. 411-426

Description

Guanosine is a purine nucleoside that is comprised of the purine base guanine attached to a ribose moiety. Mono-, di-, tri-, and cyclic monophosphorylated forms of guanosine (GMP, GDP, GTP, and cGMP, respectively) are essential for a variety of endogenous biochemical processes, such as signal transduction, metabolism, and RNA synthesis.

Chemical Properties

White, crystalline powder; odorless; mild saline taste. Very slightly soluble in cold water; soluble in boiling water, dilute mineral acids, hot acetic acid, and dilute bases; insoluble in alcohol, ether, chloroform, and benzene.

Uses

Guanosine is used as a constituent of nucleic acids. It is used in metallic paints, simulated pearls,plastics,cosmetics industry etc,. It has been also used in pharmacokinetics as a prodrug. Guanosine is used in cell culture applications as a precursor of GMP.

Uses

Guanosine has been used:

  • as a reference standard for the analysis of glucosinolates by high-performance liquid chromatography with diode-array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI/MS)
  • as a component of Mouse Embryonic Fibroblasts (MEFs) culture
  • as a standard for the detection of residual RNA contaminant in oil palm plant genome samples by HPLC

Definition

A NUCLEOSIDE present in DNA and RNA and consisting of guanine linked to D-ribose via a β-glycosidic bond.

Definition

ChEBI: A purine nucleoside in which guanine is attached to ribofuranose via a beta-N9-glycosidic bond.

General Description

Guanosine is an aromatic organic molecule and a purine nucleoside. It is present in the cerebrospinal fluid, intestinal cells, blood-brain barrier and in brain microvessels.

Biochem/physiol Actions

Guanosine nucleoside elicits cellular effect as the guanine-based purinergic system. It modulates glutamate uptake by glutamate transporters. It may have neuroprotective functionality in central nervous system disorders. Guanosine promotes neurite arborization, outgrowth, proliferation and differentiation. Administration of guanosine replenished GTP and elicits protective function in renal ischemic injury.

Purification Methods

It crystallises from water as a dihydrate. Dry it at 110o.[Beilstein 26/18 V 81.]

Guanosine Preparation Products And Raw materials

Raw materials

Preparation Products

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Guanosine Suppliers

Xinxiang Yicheng Biotechnology Co.,LTD
Tel
0373-6014999 18937330588
Email
xxycswsale@163.com
Country
China
ProdList
55
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58
Wuxi Jingyao Bio-Technology Co., Ltd.
Tel
0510-88770633 13961738808
Email
jingyaobiotech@126.com
Country
China
ProdList
301
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55
Zheng zhou nine potential chemical products co,.ltd.
Tel
+86-0371-55215939 +86-17319721973
Email
foreignsales@jiushichem.com
Country
China
ProdList
33
Advantage
58
Tai 'an Jiangzhou Biotechnology Co., LTD
Tel
13854830759 13854830759
Email
3563349062@qq.com
Country
China
ProdList
1945
Advantage
58
Hangzhou Hesheng Taiyi Biotechnology Co. , Ltd.
Tel
15868607770
Email
hstysales@126.com
Country
China
ProdList
1160
Advantage
58
Hangzhou Measure Life Technology Co.,LTD
Tel
13782581061
Email
2250804796@qq.com
Country
China
ProdList
89
Advantage
58
Shandong Debek Bioengineering Co. LTD
Tel
13854830608
Email
13854830608@163.com
Country
China
ProdList
1134
Advantage
58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
Tel
021-59167510 18117107507
Email
vip@med-life.cn
Country
China
ProdList
5021
Advantage
58
Hangzhou Qianhui Biotechnology Co., LTD
Tel
0571-16680502907 16680502907
Email
640280132@qq.com
Country
China
ProdList
794
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
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View Lastest Price from Guanosine manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.
Product
Guanosine 118-00-3
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
≥99%
Supply Ability
20tons
Release date
2024-01-10
airuikechemical co., ltd.
Product
Guanosine 118-00-3
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-03-26
Hebei Yibangte Import and Export Co. , Ltd.
Product
Guanosine 118-00-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000kg
Release date
2024-03-26

118-00-3, GuanosineRelated Search:


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