Uridine-5'-diphosphate disodium salt
- Product Name
- Uridine-5'-diphosphate disodium salt
- CAS No.
- 27821-45-0
- Chemical Name
- Uridine-5'-diphosphate disodium salt
- Synonyms
- UDP 2NA;UDP.Na2;5′-UDP,2Na;5'-UDP-Na2;Einecs 248-678-9;5'-UDP 2Na Hydrate;Diquafosol Impurity 17;Uridine 5’-diphosphate;Sodium 1-((2R,3R,4S,5R);UDP(URIDINE-5''-DIPHOSPHATE)
- CBNumber
- CB2143213
- Molecular Formula
- C9H15N2NaO12P2
- Formula Weight
- 428.16
- MOL File
- 27821-45-0.mol
Uridine-5'-diphosphate disodium salt Property
- storage temp.
- -20°C
- form
- Powder
- color
- White to Off-white
- Water Solubility
- Slightly soluble in water.
- Sensitive
- Moisture Sensitive
- BRN
- 8817400
- InChI
- InChI=1/C9H14N2O12P2.Na.H/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18);;/t4-,6-,7-,8-;;/s3
- InChIKey
- KWDGQJWFEYTPBN-IBOJMDDDSA-L
- SMILES
- O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=CC(=O)NC1=O)O.[NaH] |&1:1,2,3,15,r|
- CAS DataBase Reference
- 27821-45-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 94330
- Product name
- Uridine 5′-diphosphate disodium salt hydrate
- Purity
- ≥96.0% (HPLC)
- Packaging
- 100mg
- Price
- $126
- Updated
- 2024/03/01
- Product number
- 94330
- Product name
- Uridine 5′-diphosphate disodium salt hydrate
- Purity
- ≥96.0% (HPLC)
- Packaging
- 500mg
- Price
- $509
- Updated
- 2024/03/01
- Product number
- J64329
- Product name
- Uridine-5'-diphosphate disodium salt
- Purity
- 98%
- Packaging
- 100mg
- Price
- $71.65
- Updated
- 2024/03/01
- Product number
- J64329
- Product name
- Uridine-5'-diphosphate disodium salt
- Purity
- 98%
- Packaging
- 1g
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 18137
- Product name
- UDP (sodium salt)
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $32
- Updated
- 2024/03/01
Uridine-5'-diphosphate disodium salt Chemical Properties,Usage,Production
Description
Uridine-5'-diphosphate disodium salt (UDP-Na2) is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52 for human P2Y6 receptor). It is an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis. It has also been used as a purinergic agonist, in order to study its effect on the flux of absorbed cations in cochlear outer sulcus cells (OSC) and vestibular migratory cells (VTC). UDP-Na2 has also been used to determine the activity of nucleoside diphosphatase (NDPase) in the rabbit retina.
Uses
Uridine-5'-diphosphate disodium salt is mainly used in nucleic acid (RNA) biosynthesis and cell signalling studies. Uridine-5'-monophosphate disodium salt (UDP-MS) is a structural analogue of uridine and is used as a dietary supplement. It has been shown to inhibit phosphodiesterase and cyclic nucleotide phosphodiesterase, both of which are enzymes that degrade the secondary messenger cyclic adenosine monophosphate (cAMP).
Uses
Uridine-5'-diphosphate disodium salt (UDP-Na2) is an organometallic compound, It is a P2Y6 receptor agonist and GPR105 receptor inhibitor. It is used in studies on nucleic acid (RNA) biosynthesis and cell signaling. UDP is a nucleotide that upon phosphorylation to UTP becomes a substrate for enzymes such as RNA polymerase(s) and GTPases. These enzymes are involved in a wide range of applications from the synthesis of RNA to the regulation of G-coupled Protein Receptors (GPCR) and cell signaling molecules such as Rho-signaling via Guanine Nucleotide Exchange Factors (GEF).
Application
Uridine 5′-diphosphate disodium salt hydrate has been used:
as a standard for quantification of metabolite levels in murine tumor interstitial fluid by liquid chromatography-mass spectrometry (LC/MS)
as a UDP standard for nucleotide analysis by liquid chromatography-high resolution mass spectrometry (LC-HRMS)
to treat E6.5 retina explants in vitro, to study its effect on the entry and elongation of microglial cells into the embryonic quail retina
Biochem/physiol Actions
Uridine 5′-diphosphate (UDP) is an endogenous signaling molecule produced by damaged cells to attract macrophages. In response to neuronal damage, UDP promotes chemotaxis and chemokinesis in microglial cells. UDP serves as a ligand for P2Y receptors. UDP and uridine 5′-triphosphate (UTP) may be used in studies on nucleic acid (RNA) biosynthesis and cell signaling. UDP is a nucleotide that upon phosphorylation to UTP becomes a substrate for enzymes such as RNA polymerase(s) and GTPases. These enzymes are involved in a wide range of applications from the synthesis of RNA to the regulation of G-coupled protein receptors (GPCR) and cell signaling molecules such as Rho-signaling via guanine nucleotide exchange factors (GEF).
storage
Store at -20°C
Purification Methods
Crystallise it from MeOH. It may contain some Ba salt(s); hence stir it with Amberlite IR-120 cation exchanger (25mL, wet resin, 15-50 mesh in H+ form) in H2O (50mL) until the nucleotide dissolves. Filter, wash resin with H2O until the eluate is neutral. Combine the filtrate and washings, and adjust the pH to 8.0 with 2.0 M aqueous NaOH. Concentrate it in vacuo to a small volume (~ 20mL), and add Me2CO dropwise until crystallisation begins. Cool to 0o, and the shiny plates of di Na uridine-5’-phosphate dihydrate are filtered off and dried over P2O5 at 25o/0.1mm for 24hours (>76% recovery). UV: max at 262nm ( 10,000 M-1cm -1) in 0.1 M HCl. [Boon et al. J Chem Soc 408 1950, Smith Biochemical Preparations 8 130 1960.] [Beilstein 24 IV 1214.]
Uridine-5'-diphosphate disodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Uridine-5'-diphosphate disodium salt manufacturers
- Product
- uridine 5'-diphosphate disodium salt 27821-45-0
- Price
- US $0.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20Ton
- Release date
- 2024-10-22
- Product
- Uridine-5'-diphosphoglucose disodium salt 27821-45-0
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2024-05-17
- Product
- Uridine 5’-diphosphate disodium salt,UDP-Na2; UDP; 5'-UDP-Na2 27821-45-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98.0%min. HPLC
- Supply Ability
- 1000kg
- Release date
- 2024-11-21