Uridine-5'-diphosphate disodium salt
- Product Name
- Uridine-5'-diphosphate disodium salt
- CAS No.
- 27821-45-0
- Chemical Name
- Uridine-5'-diphosphate disodium salt
- Synonyms
- UDP 2NA;UDP.Na2;5′-UDP,2Na;5'-UDP-Na2;Einecs 248-678-9;5'-UDP 2Na Hydrate;Diquafosol Impurity 17;Uridine 5’-diphosphate;Sodium 1-((2R,3R,4S,5R);Disodiumuridinediphosphate
- CBNumber
- CB2143213
- Molecular Formula
- C9H15N2NaO12P2
- Formula Weight
- 428.16
- MOL File
- 27821-45-0.mol
Uridine-5'-diphosphate disodium salt Property
- storage temp.
- -20°C
- form
- Powder
- color
- White to Off-white
- biological source
- synthetic
- Water Solubility
- Slightly soluble in water.
- Sensitive
- Moisture Sensitive
- BRN
- 8817400
- InChI
- InChI=1/C9H14N2O12P2.Na.H/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18);;/t4-,6-,7-,8-;;/s3
- InChIKey
- KWDGQJWFEYTPBN-IBOJMDDDSA-L
- SMILES
- O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=CC(=O)NC1=O)O.[NaH] |&1:1,2,3,15,r|
- CAS DataBase Reference
- 27821-45-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 94330
- Product name
- Uridine 5′-diphosphate disodium salt hydrate
- Purity
- ≥96.0% (HPLC)
- Packaging
- 100mg
- Price
- $130
- Updated
- 2025/07/31
- Product number
- 94330
- Product name
- Uridine 5′-diphosphate disodium salt hydrate
- Purity
- ≥96.0% (HPLC)
- Packaging
- 500mg
- Price
- $550
- Updated
- 2025/07/31
- Product number
- 18137
- Product name
- UDP (sodium salt)
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 18137
- Product name
- UDP (sodium salt)
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 18137
- Product name
- UDP (sodium salt)
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $70
- Updated
- 2024/03/01
Uridine-5'-diphosphate disodium salt Chemical Properties,Usage,Production
Description
Uridine-5'-diphosphate disodium salt (UDP-Na2) is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52 for human P2Y6 receptor). It is an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis. It has also been used as a purinergic agonist, in order to study its effect on the flux of absorbed cations in cochlear outer sulcus cells (OSC) and vestibular migratory cells (VTC). UDP-Na2 has also been used to determine the activity of nucleoside diphosphatase (NDPase) in the rabbit retina.
Uses
Uridine-5'-diphosphate disodium salt is mainly used in nucleic acid (RNA) biosynthesis and cell signalling studies. Uridine-5'-monophosphate disodium salt (UDP-MS) is a structural analogue of uridine and is used as a dietary supplement. It has been shown to inhibit phosphodiesterase and cyclic nucleotide phosphodiesterase, both of which are enzymes that degrade the secondary messenger cyclic adenosine monophosphate (cAMP).
Uses
Uridine-5'-diphosphate disodium salt (UDP-Na2) is an organometallic compound, It is a P2Y6 receptor agonist and GPR105 receptor inhibitor. It is used in studies on nucleic acid (RNA) biosynthesis and cell signaling. UDP is a nucleotide that upon phosphorylation to UTP becomes a substrate for enzymes such as RNA polymerase(s) and GTPases. These enzymes are involved in a wide range of applications from the synthesis of RNA to the regulation of G-coupled Protein Receptors (GPCR) and cell signaling molecules such as Rho-signaling via Guanine Nucleotide Exchange Factors (GEF).
Application
Uridine-5'-diphosphate disodium salt hydrate has been used:
as a standard for quantification of metabolite levels in murine tumor interstitial fluid by liquid chromatography-mass spectrometry (LC/MS)
as a UDP standard for nucleotide analysis by liquid chromatography-high resolution mass spectrometry (LC-HRMS)
to treat E6.5 retina explants in vitro, to study its effect on the entry and elongation of microglial cells into the embryonic quail retina
Biochem/physiol Actions
Uridine-5'-diphosphate disodium salt is an endogenous signaling molecule produced by damaged cells to attract macrophages. In response to neuronal damage, UDP promotes chemotaxis and chemokinesis in microglial cells. UDP serves as a ligand for P2Y receptors. UDP and uridine 5′-triphosphate (UTP) may be used in studies on nucleic acid (RNA) biosynthesis and cell signaling. UDP is a nucleotide that upon phosphorylation to UTP becomes a substrate for enzymes such as RNA polymerase(s) and GTPases. These enzymes are involved in a wide range of applications from the synthesis of RNA to the regulation of G-coupled protein receptors (GPCR) and cell signaling molecules such as Rho-signaling via guanine nucleotide exchange factors (GEF).
storage
Store at -20°C
Purification Methods
Crystallise it from MeOH. It may contain some Ba salt(s); hence stir it with Amberlite IR-120 cation exchanger (25mL, wet resin, 15-50 mesh in H+ form) in H2O (50mL) until the nucleotide dissolves. Filter, wash resin with H2O until the eluate is neutral. Combine the filtrate and washings, and adjust the pH to 8.0 with 2.0 M aqueous NaOH. Concentrate it in vacuo to a small volume (~ 20mL), and add Me2CO dropwise until crystallisation begins. Cool to 0o, and the shiny plates of di Na uridine-5’-phosphate dihydrate are filtered off and dried over P2O5 at 25o/0.1mm for 24hours (>76% recovery). UV: max at 262nm ( 10,000 M-1cm -1) in 0.1 M HCl. [Boon et al. J Chem Soc 408 1950, Smith Biochemical Preparations 8 130 1960.] [Beilstein 24 IV 1214.]
Uridine-5'-diphosphate disodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Uridine-5'-diphosphate disodium salt manufacturers
- Product
- Uridine 5’-diphosphate disodium salt（UDP-Na2） 27821-45-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- ≥98.0%
- Supply Ability
- 1 ton
- Release date
- 2025-10-15
- Product
- Uridine 5’-diphosphate disodium salt (UDP- Na2) 27821-45-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- ≥99%
- Supply Ability
- 500KG
- Release date
- 2025-08-19
- Product
- uridine 5'-diphosphate disodium salt 27821-45-0
- Price
- US $0.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20Ton
- Release date
- 2024-10-22