Clodronate disodium
- Product Name
- Clodronate disodium
- CAS No.
- 22560-50-5
- Chemical Name
- Clodronate disodium
- Synonyms
- DMDP;Loron;CL2MDP;bm06011;U-82067E;lodronate;Difosfonal;clodronatesodium;sodiumclodronate;chlodronatesodium
- CBNumber
- CB0318011
- Molecular Formula
- CH5Cl2NaO6P2
- Formula Weight
- 268.88
- MOL File
- 22560-50-5.mol
Clodronate disodium Property
- Melting point:
- >330°C
- storage temp.
- room temp
- solubility
- Freely soluble in water, practically insoluble in ethanol (96 per cent), slightly soluble in methanol.
- form
- Solid
- color
- White to Off-White
- InChIKey
- HJKBJIYDJLVSAO-UHFFFAOYSA-L
- CAS DataBase Reference
- 22560-50-5(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- RTECS
- SZ7640700
- HS Code
- 29319090
- Toxicity
- mouse,LD50,intraperitoneal,780mg/kg (780mg/kg),British UK Patent Application. Vol. #2096889,
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D4434
- Product name
- Dichloromethylenediphosphonic acid disodium salt
- Packaging
- 1g
- Price
- $347
- Updated
- 2024/03/01
- Product number
- C586875
- Product name
- ClodronicAcidDisodiumSaltHydrate
- Packaging
- 5g
- Price
- $205
- Updated
- 2021/12/16
- Product number
- FC20495
- Product name
- Clodronic acid disodium salt
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FC20495
- Product name
- Clodronic acid disodium salt
- Packaging
- 2g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- FC20495
- Product name
- Clodronic acid disodium salt
- Packaging
- 5G
- Price
- $200
- Updated
- 2021/12/16
Clodronate disodium Chemical Properties,Usage,Production
Description
Clodronate disodium is a bone resorption inhibitor, useful as adjunct therapy in the treatment of osteolytic bone metastases and malignant hypercalcemia.
Chemical Properties
White Solid
Originator
Proctor & Gamble (USA)
Uses
Clodronic Acid Disodium Salt Hydrate is a bisphosphonate antiresorptive agent; bone resorption inhibitor.
Definition
ChEBI: The disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used (generally as the tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteoly ic lesions and bone pain associated with skeletal metastases.
brand name
Bonefos (Leiras Oy, Finland).
Hazard
Moderately toxic by ingestion.
Biochem/physiol Actions
Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.
Clinical Use
Bisphosphonate: Management of osteolytic lesions, hypercalcaemia and bone pain associated with skeletal metastases in patients with breast cancer or multiple myeloma
Safety Profile
A poison by intravenous route. Moderately toxic by ingestion, intraperitoneal routes. When heated to decomposition it emits toxic vapors of PO, and Cl-
Drug interactions
Potentially hazardous interactions with other drugs
Cytotoxics: concentration of estramustine increased.
Metabolism
Clodronate is not metabolised.
Over 70% of an intravenous dose is excreted unchanged
in the urine within 24 hours, the remainder being
sequestered to bone tissue. The substance which is bound
to bone is excreted more slowly, and the renal clearance is
about 75% of the plasma clearance.
Clodronate disodium Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Clodronate disodium manufacturers
- Product
- Clodronate disodium 22560-50-5
- Price
- US $50.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 98%
- Supply Ability
- 200kg/month
- Release date
- 2023-08-11
- Product
- Dichloromethylenediphosphonic acid disodium salt 22560-50-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- Clodronate disodium 22560-50-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 600 Tons
- Release date
- 2020-05-03