ChemicalBook > CAS DataBase List > Clodronate disodium

Clodronate disodium

Product Name
Clodronate disodium
CAS No.
22560-50-5
Chemical Name
Clodronate disodium
Synonyms
DMDP;Loron;CL2MDP;bm06011;U-82067E;lodronate;Difosfonal;clodronatesodium;sodiumclodronate;chlodronatesodium
CBNumber
CB0318011
Molecular Formula
CH5Cl2NaO6P2
Formula Weight
268.88
MOL File
22560-50-5.mol
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Clodronate disodium Property

Melting point:
>330°C
storage temp. 
room temp
solubility 
Freely soluble in water, practically insoluble in ethanol (96 per cent), slightly soluble in methanol.
form 
Solid
color 
White to Off-White
InChIKey
HJKBJIYDJLVSAO-UHFFFAOYSA-L
CAS DataBase Reference
22560-50-5(CAS DataBase Reference)
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Safety

WGK Germany 
3
RTECS 
SZ7640700
HS Code 
29319090
Toxicity
mouse,LD50,intraperitoneal,780mg/kg (780mg/kg),British UK Patent Application. Vol. #2096889,
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D4434
Product name
Dichloromethylenediphosphonic acid disodium salt
Packaging
1g
Price
$347
Updated
2024/03/01
TRC
Product number
C586875
Product name
ClodronicAcidDisodiumSaltHydrate
Packaging
5g
Price
$205
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20495
Product name
Clodronic acid disodium salt
Packaging
1g
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20495
Product name
Clodronic acid disodium salt
Packaging
2g
Price
$125
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
ING0002754
Product name
CLODRONATE DISODIUM
Purity
95.00%
Packaging
50MG
Price
$704.55
Updated
2021/12/16
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Clodronate disodium Chemical Properties,Usage,Production

Description

Clodronate disodium is a bone resorption inhibitor, useful as adjunct therapy in the treatment of osteolytic bone metastases and malignant hypercalcemia.

Chemical Properties

White Solid

Originator

Proctor & Gamble (USA)

Uses

Clodronic Acid Disodium Salt Hydrate is a bisphosphonate antiresorptive agent; bone resorption inhibitor.

Definition

ChEBI: The disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used (generally as the tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteoly ic lesions and bone pain associated with skeletal metastases.

brand name

Bonefos (Leiras Oy, Finland).

Hazard

Moderately toxic by ingestion.

Biochem/physiol Actions

Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.

Clinical Use

Bisphosphonate: Management of osteolytic lesions, hypercalcaemia and bone pain associated with skeletal metastases in patients with breast cancer or multiple myeloma

Safety Profile

A poison by intravenous route. Moderately toxic by ingestion, intraperitoneal routes. When heated to decomposition it emits toxic vapors of PO, and Cl-

Drug interactions

Potentially hazardous interactions with other drugs
Cytotoxics: concentration of estramustine increased.

Metabolism

Clodronate is not metabolised.
Over 70% of an intravenous dose is excreted unchanged in the urine within 24 hours, the remainder being sequestered to bone tissue. The substance which is bound to bone is excreted more slowly, and the renal clearance is about 75% of the plasma clearance.

Clodronate disodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Clodronate disodium Suppliers

Canada 1 China 134 Europe 3 Germany 1 India 3 South Korea 1 Switzerland 1 United Kingdom 3 United States 19 Global 166
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View Lastest Price from Clodronate disodium manufacturers

XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
Product
Clodronate disodium 22560-50-5
Price
US $50.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
98%
Supply Ability
200kg/month
Release date
2023-08-11
Shaanxi Dideu Medichem Co. Ltd
Product
Clodronate disodium 22560-50-5
Price
US $1.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2020-01-16
Zhuozhou Wenxi import and Export Co., Ltd
Product
Dichloromethylenediphosphonic acid disodium salt 22560-50-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

22560-50-5, Clodronate disodiumRelated Search:

Sodium Monofluorophosphate Ethylenediaminetetraacetic acid disodium salt Ethyl 2-(Chlorosulfonyl)acetate Disodium pamidronate CLODRONIC ACID Citric acid Folic acid Ascoric Acid Chrysene Disodium clodronate tetrahydrate DMDP,DMDP[(2R,5R)-BIS(HYDROXYMETHYL)-(3R,4R)-DIHYDROXYPYRROLIDINE],2,5-Dideoxy-2,5-imino-D-mannitol, DMDP DMDP-TAT-59 METHYLENEBISPHOSPHONIC ACID-P,P'-DISODIUM SALT CHLOROMETHYLPHOSPHONIC ACID (dichloromethyl)phosphonic acid Clodronate disodium

  • CL2MDP
  • Phosphonic acid, P,P'-(dichloromethylene)bis-, sodium salt (1:2)
  • Clodronate disodium, >=98%
  • DICHLOROMETHYLENEDIPHOPHONIC ACID DISODIUM SALT
  • DICHLOROMETHYLENEDIPHOSPHONIC ACID DISODIUM SALT
  • DMDP
  • CLODRONIC ACID DISODIUM SALT
  • CLODRONATE DISODIUM
  • (dichloromethylene)bis-phosphonicacidisodiumsalt
  • (dichloromethylene)di-phosphonicacidisodiumsalt
  • bm06011
  • chlodronatesodium
  • clodronatesodium
  • dichloromethanediphosphonate
  • disodium(dichloromethylene)bisphosphonate
  • disodium [dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxy-phosphinate
  • Clodronic Acid, Disodium Salt, Hydrate
  • (Dichloromethylene)diphosphonate disodium
  • disodium [dichloro(phosphonato)methyl]-dioxido-oxophosphorane
  • disodiumclodronate
  • lodronate
  • sodiumclodronate
  • Clodronate Disodium, Bonefos, Clasteon, Clastoban
  • disodium dihydrogen (dichloromethylene)diphosphonate
  • DICHLOROMETHYLENEDIPHOSPHONIC ACID
  • ClodronateAcidDisodiumSalt
  • clodronate disodium，CLD
  • Difosfonal
  • Loron
  • (Dichloromethylene)bis(phosphonic acid hydrogen sodium) salt
  • Disodium crodronate
  • U-82067E
  • disodium [dichloro-[hydroxy(oxidanidyl)phosphoryl]methyl]-hydroxy-phosphinate
  • disodium [dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate
  • clodronic acid, sodium salt
  • Cl2MDP, Clodronic acid disodium salt, DMDP
  • clodronicaciddisodiumsal
  • CAS22560-50-5 clodronic acid disodium salt
  • Sodium (dichloro(phosphono)methyl)phosphonate
  • 22560-50-5
  • CH2Cl2O6P22Na
  • CH2Cl2Na2O6P2
  • CH2O6Cl2Na2P2
  • CH4Cl2O6P02Na
  • Clodronic Acid Disodium
  • Other APIs
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Phosphorylating and Phosphitylating Agents
  • All Inhibitors
  • 22560-50-5