Clodronate disodium

ChemicalBook > CAS DataBase List > Clodronate disodium

Product Name: Clodronate disodium
CAS No.: 22560-50-5
Chemical Name: Clodronate disodium
Synonyms: DMDP;Loron;CL2MDP;bm06011;U-82067E;lodronate;Difosfonal;clodronatesodium;sodiumclodronate;chlodronatesodium
CBNumber: CB0318011
Molecular Formula: CH5Cl2NaO6P2
Formula Weight: 268.88
MOL File: 22560-50-5.mol

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Clodronate disodium Property

Melting point:: >330°C
storage temp.: room temp
solubility: Freely soluble in water, practically insoluble in ethanol (96 per cent), slightly soluble in methanol.
form: Solid
color: White to Off-White
InChIKey: HJKBJIYDJLVSAO-UHFFFAOYSA-L
CAS DataBase Reference: 22560-50-5(CAS DataBase Reference)

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Safety

WGK Germany: 3
RTECS: SZ7640700
HS Code: 29319090
Toxicity: mouse,LD50,intraperitoneal,780mg/kg (780mg/kg),British UK Patent Application. Vol. #2096889,

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D4434
Product name: Dichloromethylenediphosphonic acid disodium salt
Packaging: 1g
Price: $347
Updated: 2024/03/01

TRC

Product number: C586875
Product name: ClodronicAcidDisodiumSaltHydrate
Packaging: 5g
Price: $205
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20495
Product name: Clodronic acid disodium salt
Packaging: 1g
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20495
Product name: Clodronic acid disodium salt
Packaging: 2g
Price: $125
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: ING0002754
Product name: CLODRONATE DISODIUM
Purity: 95.00%
Packaging: 50MG
Price: $704.55
Updated: 2021/12/16

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Clodronate disodium Chemical Properties,Usage,Production

Description

Clodronate disodium is a bone resorption inhibitor, useful as adjunct therapy in the treatment of osteolytic bone metastases and malignant hypercalcemia.

Chemical Properties

White Solid

Originator

Proctor & Gamble (USA)

Uses

Clodronic Acid Disodium Salt Hydrate is a bisphosphonate antiresorptive agent; bone resorption inhibitor.

Definition

ChEBI: The disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used (generally as the tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteoly ic lesions and bone pain associated with skeletal metastases.

brand name

Bonefos (Leiras Oy, Finland).

Hazard

Moderately toxic by ingestion.

Biochem/physiol Actions

Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.

Clinical Use

Bisphosphonate: Management of osteolytic lesions, hypercalcaemia and bone pain associated with skeletal metastases in patients with breast cancer or multiple myeloma

Safety Profile

A poison by intravenous route. Moderately toxic by ingestion, intraperitoneal routes. When heated to decomposition it emits toxic vapors of PO, and Cl-

Drug interactions

Potentially hazardous interactions with other drugs
Cytotoxics: concentration of estramustine increased.

Metabolism

Clodronate is not metabolised.
Over 70% of an intravenous dose is excreted unchanged in the urine within 24 hours, the remainder being sequestered to bone tissue. The substance which is bound to bone is excreted more slowly, and the renal clearance is about 75% of the plasma clearance.

Clodronate disodium Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Clodronate disodium manufacturers

XI'AN TIANGUANGYUAN BIOTECH CO., LTD.

Product: Clodronate disodium 22560-50-5
Price: US $50.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 98%
Supply Ability: 200kg/month
Release date: 2023-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Dichloromethylenediphosphonic acid disodium salt 22560-50-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Shaanxi Dideu Medichem Co. Ltd

Product: Clodronate disodium 22560-50-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 600 Tons
Release date: 2020-05-03

22560-50-5, Clodronate disodiumRelated Search:

Sodium Monofluorophosphate Ethylenediaminetetraacetic acid disodium salt Ethyl 2-(Chlorosulfonyl)acetate Disodium pamidronate CLODRONIC ACID Citric acid Folic acid Ascoric Acid Chrysene Disodium clodronate tetrahydrate DMDP,DMDP[(2R,5R)-BIS(HYDROXYMETHYL)-(3R,4R)-DIHYDROXYPYRROLIDINE],2,5-Dideoxy-2,5-imino-D-mannitol, DMDP DMDP-TAT-59 METHYLENEBISPHOSPHONIC ACID-P,P'-DISODIUM SALT CHLOROMETHYLPHOSPHONIC ACID (dichloromethyl)phosphonic acid Clodronate disodium

CL2MDP

Phosphonic acid, P,P'-(dichloromethylene)bis-, sodium salt (1:2)

Clodronate disodium, >=98%

DICHLOROMETHYLENEDIPHOPHONIC ACID DISODIUM SALT

DICHLOROMETHYLENEDIPHOSPHONIC ACID DISODIUM SALT

DMDP

CLODRONIC ACID DISODIUM SALT

CLODRONATE DISODIUM

(dichloromethylene)bis-phosphonicacidisodiumsalt

(dichloromethylene)di-phosphonicacidisodiumsalt

bm06011

chlodronatesodium

clodronatesodium

dichloromethanediphosphonate

disodium(dichloromethylene)bisphosphonate

disodium [dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxy-phosphinate

Clodronic Acid, Disodium Salt, Hydrate

(Dichloromethylene)diphosphonate disodium

disodium [dichloro(phosphonato)methyl]-dioxido-oxophosphorane

disodiumclodronate

lodronate

sodiumclodronate

Clodronate Disodium, Bonefos, Clasteon, Clastoban

disodium dihydrogen (dichloromethylene)diphosphonate

DICHLOROMETHYLENEDIPHOSPHONIC ACID

ClodronateAcidDisodiumSalt

clodronate disodium，CLD

Difosfonal

Loron

(Dichloromethylene)bis(phosphonic acid hydrogen sodium) salt

Disodium crodronate

U-82067E

disodium [dichloro-[hydroxy(oxidanidyl)phosphoryl]methyl]-hydroxy-phosphinate

disodium [dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate

clodronic acid, sodium salt

Cl2MDP, Clodronic acid disodium salt, DMDP

clodronicaciddisodiumsal

CAS22560-50-5 clodronic acid disodium salt

Sodium (dichloro(phosphono)methyl)phosphonate

22560-50-5

CH2Cl2O6P22Na

CH2Cl2Na2O6P2

CH2O6Cl2Na2P2

CH4Cl2O6P02Na

Clodronic Acid Disodium

Other APIs

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Phosphorylating and Phosphitylating Agents

All Inhibitors

22560-50-5