Uridine-5'-diphosphate disodium salt

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Uridine-5'-diphosphate disodium salt

Product Name: Uridine-5'-diphosphate disodium salt
CAS No.: 27821-45-0
Chemical Name: Uridine-5'-diphosphate disodium salt
Synonyms: UDP 2NA;UDP.Na2;5′-UDP,2Na;5'-UDP-Na2;Einecs 248-678-9;5'-UDP 2Na Hydrate;Diquafosol Impurity 17;Uridine 5’-diphosphate;Sodium 1-((2R,3R,4S,5R);UDP(URIDINE-5''-DIPHOSPHATE)
CBNumber: CB2143213
Molecular Formula: C9H15N2NaO12P2
Formula Weight: 428.16
MOL File: 27821-45-0.mol

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Uridine-5'-diphosphate disodium salt Property

storage temp.: -20°C
form: Powder
color: White to Off-white
Water Solubility: Slightly soluble in water.
Sensitive: Moisture Sensitive
BRN: 8817400
InChI: InChI=1/C9H14N2O12P2.Na.H/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18);;/t4-,6-,7-,8-;;/s3
InChIKey: KWDGQJWFEYTPBN-IBOJMDDDSA-L
SMILES: O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=CC(=O)NC1=O)O.[NaH] |&1:1,2,3,15,r|
CAS DataBase Reference: 27821-45-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 10-21
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 94330
Product name: Uridine 5′-diphosphate disodium salt hydrate
Purity: ≥96.0% (HPLC)
Packaging: 100mg
Price: $126
Updated: 2024/03/01

Sigma-Aldrich

Product number: 94330
Product name: Uridine 5′-diphosphate disodium salt hydrate
Purity: ≥96.0% (HPLC)
Packaging: 500mg
Price: $509
Updated: 2024/03/01

Alfa Aesar

Product number: J64329
Product name: Uridine-5'-diphosphate disodium salt
Purity: 98%
Packaging: 100mg
Price: $71.65
Updated: 2024/03/01

Alfa Aesar

Product number: J64329
Product name: Uridine-5'-diphosphate disodium salt
Purity: 98%
Packaging: 1g
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 18137
Product name: UDP (sodium salt)
Purity: ≥95%
Packaging: 100mg
Price: $32
Updated: 2024/03/01

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Uridine-5'-diphosphate disodium salt Chemical Properties,Usage,Production

Uses

Uridine-5'-diphosphate disodium salt (UDP-Na2) is an organometallic compound, It is a P2Y6 receptor agonist and GPR105 receptor inhibitor. It is used in studies on nucleic acid (RNA) biosynthesis and cell signaling. UDP is a nucleotide that upon phosphorylation to UTP becomes a substrate for enzymes such as RNA polymerase(s) and GTPases. These enzymes are involved in a wide range of applications from the synthesis of RNA to the regulation of G-coupled Protein Receptors (GPCR) and cell signaling molecules such as Rho-signaling via Guanine Nucleotide Exchange Factors (GEF).

Application

Uridine 5′-diphosphate disodium salt hydrate has been used:
as a standard for quantification of metabolite levels in murine tumor interstitial fluid by liquid chromatography-mass spectrometry (LC/MS)
as a UDP standard for nucleotide analysis by liquid chromatography-high resolution mass spectrometry (LC-HRMS)
to treat E6.5 retina explants in vitro, to study its effect on the entry and elongation of microglial cells into the embryonic quail retina

Biochem/physiol Actions

Uridine 5′-diphosphate (UDP) is an endogenous signaling molecule produced by damaged cells to attract macrophages. In response to neuronal damage, UDP promotes chemotaxis and chemokinesis in microglial cells. UDP serves as a ligand for P2Y receptors. UDP and uridine 5′-triphosphate (UTP) may be used in studies on nucleic acid (RNA) biosynthesis and cell signaling. UDP is a nucleotide that upon phosphorylation to UTP becomes a substrate for enzymes such as RNA polymerase(s) and GTPases. These enzymes are involved in a wide range of applications from the synthesis of RNA to the regulation of G-coupled protein receptors (GPCR) and cell signaling molecules such as Rho-signaling via guanine nucleotide exchange factors (GEF).

storage

Store at -20°C

Purification Methods

Crystallise it from MeOH. It may contain some Ba salt(s); hence stir it with Amberlite IR-120 cation exchanger (25mL, wet resin, 15-50 mesh in H+ form) in H2O (50mL) until the nucleotide dissolves. Filter, wash resin with H2O until the eluate is neutral. Combine the filtrate and washings, and adjust the pH to 8.0 with 2.0 M aqueous NaOH. Concentrate it in vacuo to a small volume (~ 20mL), and add Me2CO dropwise until crystallisation begins. Cool to 0o, and the shiny plates of di Na uridine-5’-phosphate dihydrate are filtered off and dried over P2O5 at 25o/0.1mm for 24hours (>76% recovery). UV: max at 262nm ( 10,000 M-1cm -1) in 0.1 M HCl. [Boon et al. J Chem Soc 408 1950, Smith Biochemical Preparations 8 130 1960.] [Beilstein 24 IV 1214.]

Uridine-5'-diphosphate disodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Uridine-5'-diphosphate disodium salt manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: Uridine-5'-diphosphoglucose disodium salt 27821-45-0
Price: US $30.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-05-17

Hebei Guanlang Biotechnology Co., Ltd.

Product: Uridine 5’-diphosphate disodium salt 27821-45-0
Price: US $1.00/PCS
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-01-18

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Uridine-5'-diphosphate disodium salt 27821-45-0
Price: US $75.00-750.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-10-17

27821-45-0, Uridine-5'-diphosphate disodium saltRelated Search:

1-beta-D-Arabinofuranosyluracil Clodronate disodium Ethylenediaminetetraacetic acid disodium salt Sodium Monofluorophosphate Uridine-5'-triphosphoric acid trisodium salt Uridine 5′-monophosphate disodium salt UMP Uridine Pamidronate disodium salt Doxifluridine Sodium Phosphate, Dibasic UDP URODILATIN HUMAN Uridine Diphosphate Choline Diquafosol UDP-rhamnose Guanosine-5'-diphosphate disodium salt uridine 5'-diphosphoglucose disodium salt from saccharomyces cerevisiae,Uridine 5'-diphosphoglucose disodium salt

UDP 2NA

URIDINE 5'-DIPHOSPHATE DISODIUM SALT

URIDINE 5'-DIPHOSPHORIC ACID DISODIUM SALT

Uridine 5'-diphosphate disodiu salt

Diquafosol Impurity 2(UDP Sodium Salt)

5'-UDP-Na2

Uridine 5'-(trihydrogen diphosphate), disodium salt

UDP(URIDINE-5''-DIPHOSPHATE)

URIDINE-5''- DIPHOSPHATE, DISODIUM SALT(UDP.NA2)

URIDINE-5''-DIPHOSPHATE DISODIUM SALT HYDRATE (UDP)

URIDINE 5''- DIPHOSPHATE DISODIUM SALT (5''-UDP-NA2)

Uriidine-5'-diphosphate, disodium salt

Uridine-5'-diphosphoglucose disodium salt

Einecs 248-678-9

5′-UDP,2Na

UDP.Na2

SodiuM 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyriMidin-5-yl hydrogendiphosphate

-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl hydrogendiphosphate

Sodium 1-((2R,3R,4S,5R)

5'-UDP 2Na Hydrate

Uridine 5'-diphosphate disodium salt hydrate, ≥96.0% (HPLC)

Uridine-5'-diphosphoglucose disodium salt (UDP)

Uridine 5'-diphosphate disodium salt hyd

ridine 5'-diphosphate disodium salt

Uridine 5'-(trihydrogen diphosphate), sodium salt (1:2)

Uridine 5'-diphosphoric acid disodium

Uridine-5-diphosphate disodium

Uridine 5'-diphosphate Disodium Salt Monohydrate

Uridine -5- disodium diphosphate

sodium ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen diphosphate

((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate, sodium salt

glucuronidation,Endogenous Metabolite,nucleic,P2Y6,P2Y14,P2Y Receptor,substrates,Uridine5'diphosphate disodium salt,inhibit,Inhibitor,acid,Uridine 5' diphosphate disodium salt,DNA/RNA Synthesis

Uridine 5＇-diphosphate disodium salt ·X Hydrate

Diquafosol Impurity 17

Uridine -5'- diphosphate disodium salt(UDP-Na,)

Uridine 5’-diphosphate

Uridine 5'-diphosphate disodium salt hydrate

Uridine 5＇-diphosphate disodium salt ·X Hydrate

Uridine 5'-diphosphate disodium salt (UDP- Na2)

Uridine 5'-diphosphate Disodium Salt

Uridine-5'-diphosphate sodium salt (UDP)

27821-45-0

C9H12N2Na2O12P2

C9H12N2Na2O12P23H2O

C9H12N2Na2O12P2xH2O

C9H12N2O13P22Na

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27821-45-0