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Guanosine-5'-diphosphate disodium salt

Uses
Product Name
Guanosine-5'-diphosphate disodium salt
CAS No.
7415-69-2
Chemical Name
Guanosine-5'-diphosphate disodium salt
Synonyms
GDP;GDP.Na2;GDP*2Na;GDP, NA2H;5'-GDP-Na2;5'-GDP 3NA;5'-GDP,2Na;Einecs 231-026-2;en pyrophosphate);Sodium (2R,3R,4R,5R)
CBNumber
CB1124550
Molecular Formula
C10H16N5NaO11P2
Formula Weight
467.2
MOL File
7415-69-2.mol
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Guanosine-5'-diphosphate disodium salt Property

Melting point:
>280°C (dec.)
storage temp. 
-20°C
solubility 
H2O: 50 mg/mL, clear, colorless
form 
Powder
color 
White
biological source
Porcine brain
microbial (Corynebacterium sp)
synthetic
Water Solubility 
Soluble in water
Stability:
Hygroscopic
InChIKey
PVMPTWQLNDHIEV-NGPBCCOENA-N
SMILES
O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=NC2C(NC(N)=NC1=2)=O)O.[NaH] |&1:1,2,3,15,r|
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36/37/39-27-26
WGK Germany 
3
F 
3-10-21
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
51060
Product name
Guanosine 5′-diphosphate disodium salt
Purity
≥90% (HPLC)
Packaging
100mg
Price
$219
Updated
2025/07/31
Sigma-Aldrich
Product number
51060
Product name
Guanosine 5′-diphosphate disodium salt
Purity
≥90% (HPLC)
Packaging
500mg
Price
$721
Updated
2025/07/31
Usbiological
Product number
296168
Product name
Guanosine 5'-Diphosphate Disodium Salt
Packaging
1g
Price
$319
Updated
2021/12/16
TRC
Product number
G837929
Product name
Guanosine5''-DiphosphateDisodiumSalt(~80%)
Packaging
500mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
NG09782
Product name
Guanosine 5'-diphosphate disodium salt
Packaging
5G
Price
$130
Updated
2021/12/16
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Guanosine-5'-diphosphate disodium salt Chemical Properties,Usage,Production

Uses

Guanosine 5'-diphosphate disodium salt is a useful research chemical.

Uses

Guanosine-5'-diphosphate disodium salt is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors. It is also used to study cell signaling processes mediate by guanine nucleotide exchange factors.

General Description

Guanosine 5′-diphosphate (GDP) is a purine nucleotide and is interconvertible to guanosine by the action of ectonucleotidases and by nucleoside phosphorylase into guanine. GDP is majorly acted upon by 5′‐ectonucleotidases in neuronal cells.

Biochem/physiol Actions

Guanosine based nucleosides play a key role in multiple cellular processes and generation growth factors. Elevated levels of guanosine 5′-diphosphate (GDP) is associated with the pathogenesis of neurological disorders. GDP is bound to G protein . G protein coupled receptors (GPCRs) activate G proteins by exchanging the bound GDP to GTP. GDP is potent inhibitor agent of hepcidin- ferroportin complex and may be effective for promoting erythropoiesis and treating anemia of inflammation(AI).

in vivo

Guanosine 5'-diphosphate disodium salt (30 mg/kg, i.p., a single dose for 24 h) combined with FeSO4 (2 mg/kg, i.p., a single dose for 24 h) suppresses the iron storage ferritin level, thus preventing Hepcidin (HY-P70400)-induced internalization of FPN with increased iron absorption in normal mice[2].
Guanosine 5'-diphosphate disodium salt (30 mL/kg, i.p., three times a week for two weeks) can improve turpentine-induced inflammatory anemia in mice[1].

Animal Model:Male BALB/c mice[2].
Dosage:30 mL/kg
Administration:Intraperitoneal injection (i.p.)
Result:Increased hemoglobin levels and serum iron levels in the long-term dosing model.
Decreased Hamp mRNA expression, and spleen iron content was reduced by 46% in the short-term dosing model.

IC 50

Human Endogenous Metabolite

Guanosine-5'-diphosphate disodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Guanosine-5'-diphosphate disodium salt Suppliers

China 260 Europe 1 Germany 2 India 1 Japan 2 Switzerland 1 United Kingdom 4 United States 18 Global 289
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
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jkinfo@jkchemical.com
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China
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96815
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Hongene Biotech Corporation
Tel
021-64757213
Fax
86-21-64700613
Email
info@hongene.com
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China
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Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
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China
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Wuhu Huaren Science and Technology Co., Ltd.
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0553-5842013-801 18155347026
Fax
086-553-5843138
Email
jinhuaren@huarensh.com
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China
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Wuhan Wei Shunda Technology Development Co., Ltd.
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86-027-88774375
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86-027-88416321
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mwmwhot@163.com
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China
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
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China
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China DongFan Chemical Co.,LTD
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86-0571-85151182
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86-0571-85151182
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China
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Nanjing MeiBo Biological Technology Co., Ltd.
Tel
025-58619198
Fax
025-58619197
Email
sales@mbbio.com
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China
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XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768836
Email
1791901229@qq.com
Country
China
ProdList
6950
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Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
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China
ProdList
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View Lastest Price from Guanosine-5'-diphosphate disodium salt manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Guanosine-5'-diphosphate disodium salt 7415-69-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%min
Supply Ability
1000kg
Release date
2023-01-13
Hebei Chuanghai Biotechnology Co., Ltd
Product
Guanosine 5’-diphosphate disodium salt 7415-69-2
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-05
Hangzhou Meiya Pharmaceutical Co Ltd
Product
Guanosine 5’-diphosphate disodium salt（GDP-Na2） 7415-69-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
≥95.0%
Supply Ability
1000 kg
Release date
2024-02-06

7415-69-2, Guanosine-5'-diphosphate disodium saltRelated Search:

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  • GUANOSINE-5'-DIPHOSPHATE MONOSODIUM SALT
  • GUANOSINE-5'-DIPHOSPHORIC ACID, DISODIUM
  • GDP, NA2H
  • GDP
  • 5'-GDP-Na<SUB2></SUB>
  • guanosine 5-(disodium hydrogen pyrophosphate)
  • GUANOSINE 5'-DIPHOSPHATE DISODIUM SALT 85+%
  • Guanosine 5-(trihydrogen diphosphate), disodium salt
  • Guanosine-5''-diphosphoric acid disodium salt
  • 5'-GDP-Na2
  • Guanosine-5'-diphosphate disodium salt
  • Einecs 231-026-2
  • -2-(2-amino-6-oxo-1H-purin-9(6H)
  • -5-(((hydroxy(phosphonooxy)
  • Sodium (2R,3R,4R,5R)
  • tetrahydrofuran-3,4-bis(olate)
  • 5'-GDP 3NA
  • GUANOSINE5-DIPHOSPHATE (GDP)
  • 5'-GDP,2Na
  • GDP.Na2
  • Guanosine-5'-diphosphate(GDP),diaodium salt
  • SodiuM (2R,3R,4R,5R)-2-(2-aMino-6-oxo-1H-purin-9(6H)-yl)-5-(((hydroxy(phosphonooxy)phosphoryl)oxy)Methyl)tetrahydrofuran-3,4-bis(olate)
  • GDP*2Na
  • 7415-69-2, MFCD00084665, Guanosine 5'-(disodium hydrogen pyrophosphate)
  • GDP, 400mM sodium salt solution
  • Guanosine 5'-diphosphate, 400mM sodium salt solution
  • Guanosine 5'-Diphosphate Disodium Salt (~80%)
  • 7415-69-2, MFCD00084665, g
  • en pyrophosphate)
  • uanosine 5'-(disodium hydrog
  • Guanosine 5'-diphosphate disodium salt >=90% (HPLC)
  • Guanosine 5'-diphosphate disodium sal
  • tianfu-chem_GDP-Na2//Guanosine-5'-diphosphate disodium salt，7415-69-2
  • Guanosine Impurity 2 Disodium Salt
  • ((2R,3S,4R,5R)-5-(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate, disodium salt
  • ((2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate, sodium salt
  • Guanosine-5'-diphosphatedisodiumsaltGuanosine-5'-diphosphatedisodiumsalt
  • Guanosine diphosphate disodium salt (GDP)
  • Guanosine 5'-(trihydrogen diphosphate), disodium salt
  • Guanosine 5''-diphosphate [GDP] disodium salt, Nucleoside diphosphate
  • Guanosine 5''-diphosphate disodium salt
  • Guanosine-5-diphosphate disodium salt (GDP 2Na)
  • disodium[[(3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-2-oxolanyl]methoxy-oxidophosphoryl]hydrogenphosphate
  • 7415-69-2
  • C10H13N5Na2O11P2
  • C10H13N5O11P2Na2
  • C10H13N5O11P22Na
  • Biochemicals and Reagents
  • BioChemical
  • Metabolomics
  • Metabolic Pathways
  • Metabolites and Cofactors on the Metabolic Pathways Chart
  • Nucleotides
  • Nucleotide
  • Nucleosides, Nucleotides, Oligonucleotides
  • Material
  • Pharmaceutical
  • 7415-69-2