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Pamidronate disodium salt

Product Name
Pamidronate disodium salt
CAS No.
57248-88-1
Chemical Name
Pamidronate disodium salt
Synonyms
cgp23339a;PAMIDRONATE;CGP 23339AE;PAMIDRONICDISODIUMSALT;PaMidronate DisodiuM API;Pamidronate disodium salt;Disodium Pamidronate Pamidronate (sodium salt);Disodium Pamidronate Hydrate;Pamidronate disodium hydrate
CBNumber
CB9707409
Molecular Formula
C3H9NNa2O7P2.xH2O
Formula Weight
279.03
MOL File
57248-88-1.mol
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Pamidronate disodium salt Property

Melting point:
300 °C
storage temp. 
2-8°C
solubility 
H2O: 28 mg/mL
form 
solid
color 
white
Merck 
14,7003
CAS DataBase Reference
57248-88-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-48-41-37/38-20/21/22
Safety Statements 
22-26-36/37/39-45
RIDADR 
3077
WGK Germany 
3
RTECS 
SZ6525000
HazardClass 
IRRITANT
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P2371
Product name
Pamidronate disodium salt hydrate
Purity
≥95% (NMR), solid
Packaging
10mg
Price
$112
Updated
2021/03/22
Sigma-Aldrich
Product number
P2371
Product name
Pamidronate disodium salt hydrate
Purity
≥95% (NMR), solid
Packaging
100mg
Price
$516
Updated
2021/03/22
TCI Chemical
Product number
D3921
Product name
Disodium Pamidronate Hydrate
Purity
>97.0%(T)
Packaging
100mg
Price
$43
Updated
2021/03/22
TCI Chemical
Product number
D3921
Product name
Disodium Pamidronate Hydrate
Purity
>97.0%(T)
Packaging
1g
Price
$251
Updated
2021/03/22
Cayman Chemical
Product number
23699
Product name
Pamidronate (sodium salt)
Purity
≥98%
Packaging
25mg
Price
$40
Updated
2021/03/22
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Pamidronate disodium salt Chemical Properties,Usage,Production

Description

Disodium pamidronate is a calcium metabolism regulator useful in the treatment of hypercalcemia associated with malignancy. It presumably reduces the bone resorption of calcium by inhibiting the formation and attachment of osteoclasts. Other potential uses include osteoporosis and calcitonin-resistant Paget’s disease.

Chemical Properties

White Crystals

Originator

Henkel (United Kingdom)

Uses

A bisphosphonate antiresorptive agent; bone resorption inhibitor.

Uses

Pamidronate disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis. It is used to prevent bone loss, and treat osteoporosis.

Uses

A farnesyl diphosphate synthase inhibitor

Manufacturing Process

For a batch size of 5 L, 587.5 g (3.2 moles) of mannitol is dissolved in 3.5 L of water. Pamidronic acid (31.6 g, 0.133 moles) is mixed with a 1.0 L aliquot of the mannitol solution to form a slurry. The slurry is then transferred into the remainder of the mannitol solution, and stirred for at least 15 min. Aqueous 1 N sodium hydroxide (270 ml) is then added and the mixture is stirred until a clear, colorless solution results. The pH is then adjusted to 6.50.1 using either 1 M aqueous phosphoric acid or 1 N aqueous sodium hydroxide, as needed. The solution is then filtered through a 0.22 micron filter, and filled at 20°C into vials at 4.0 ml (4.172 g)/vial, under sterile conditions. The aqueous solution is frozen at -37°C and lyophilized (20 mbar, 20°-40°C) to yield 1,250 vials, each containing 30 mg of amorphous disodium pamidronate. The vials are sealed under positive nitrogen pressure. The disodium pamidronate is amorphous (noncrystalline) by X-ray diffraction and contains 0.7 wt-% water.

brand name

Aredia (Novartis).

Therapeutic Function

Bone resorption suppressant

Veterinary Drugs and Treatments

Pamidronate may be useful in treating hypercalcemia associated with vitamin D-related toxicoses or hypercalcemia of malignancy. There is ongoing research on the use of this drug to determine if it has clinical usefulness in directly treating “micro-metastases” in osteosarcomas.

Pamidronate disodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Pamidronate disodium salt Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5948
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057-
Fax
0757-86311057
Email
sales.gd@hwrkchemical.com
Country
China
ProdList
17295
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Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43499
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35909
Advantage
56
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
20007
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202- ; ;
Email
jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com
Country
China
ProdList
43255
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
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View Lastest Price from Pamidronate disodium salt manufacturers

Dideu Industries Group Limited
Product
Pamidronate disodium salt USP/EP/BP 57248-88-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-28
Zhuozhou Wenxi import and Export Co., Ltd
Product
Pamidronate disodium salt 57248-88-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Pamidronate disodium salt 57248-88-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

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