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Pamidronate disodium salt

Product Name
Pamidronate disodium salt
CAS No.
57248-88-1
Chemical Name
Pamidronate disodium salt
Synonyms
cgp23339a;PAMIDRONATE;CGP 23339AE;PAMIDRONICDISODIUMSALT;PaMidronate DisodiuM API;Pamidronate disodium salt;Disodium Pamidronate Pamidronate (sodium salt);Disodium Pamidronate Hydrate;Pamidronate disodium hydrate
CBNumber
CB9707409
Molecular Formula
C3H12NNaO7P2
Formula Weight
259.07
MOL File
57248-88-1.mol
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Pamidronate disodium salt Property

Melting point:
300 °C
storage temp. 
2-8°C
solubility 
H2O: 28 mg/mL
form 
solid
color 
white
Merck 
14,7003
Stability:
Hygroscopic
CAS DataBase Reference
57248-88-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-48-41-37/38-20/21/22
Safety Statements 
22-26-36/37/39-45
RIDADR 
3077
WGK Germany 
3
RTECS 
SZ6525000
HazardClass 
IRRITANT
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P2371
Product name
Pamidronate disodium salt hydrate
Purity
≥95% (NMR), solid
Packaging
10mg
Price
$133
Updated
2024/03/01
Sigma-Aldrich
Product number
P2371
Product name
Pamidronate disodium salt hydrate
Purity
≥95% (NMR), solid
Packaging
100mg
Price
$616
Updated
2024/03/01
Sigma-Aldrich
Product number
BP615
Product name
Disodium pamidronate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$259
Updated
2023/06/20
TCI Chemical
Product number
D3921
Product name
Disodium Pamidronate Hydrate
Purity
>97.0%(T)
Packaging
100mg
Price
$52
Updated
2024/03/01
TCI Chemical
Product number
D3921
Product name
Disodium Pamidronate Hydrate
Purity
>97.0%(T)
Packaging
1g
Price
$302
Updated
2024/03/01
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Pamidronate disodium salt Chemical Properties,Usage,Production

Description

Disodium pamidronate is a calcium metabolism regulator useful in the treatment of hypercalcemia associated with malignancy. It presumably reduces the bone resorption of calcium by inhibiting the formation and attachment of osteoclasts. Other potential uses include osteoporosis and calcitonin-resistant Paget’s disease.

Chemical Properties

White Crystals

Originator

Henkel (United Kingdom)

Uses

Pamidronate disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis. It is used to prevent bone loss, and treat osteoporosis.

Uses

A farnesyl diphosphate synthase inhibitor

Uses

A bisphosphonate antiresorptive agent; bone resorption inhibitor.

Manufacturing Process

For a batch size of 5 L, 587.5 g (3.2 moles) of mannitol is dissolved in 3.5 L of water. Pamidronic acid (31.6 g, 0.133 moles) is mixed with a 1.0 L aliquot of the mannitol solution to form a slurry. The slurry is then transferred into the remainder of the mannitol solution, and stirred for at least 15 min. Aqueous 1 N sodium hydroxide (270 ml) is then added and the mixture is stirred until a clear, colorless solution results. The pH is then adjusted to 6.50.1 using either 1 M aqueous phosphoric acid or 1 N aqueous sodium hydroxide, as needed. The solution is then filtered through a 0.22 micron filter, and filled at 20°C into vials at 4.0 ml (4.172 g)/vial, under sterile conditions. The aqueous solution is frozen at -37°C and lyophilized (20 mbar, 20°-40°C) to yield 1,250 vials, each containing 30 mg of amorphous disodium pamidronate. The vials are sealed under positive nitrogen pressure. The disodium pamidronate is amorphous (noncrystalline) by X-ray diffraction and contains 0.7 wt-% water.

brand name

Aredia (Novartis).

Therapeutic Function

Bone resorption suppressant

Biochem/physiol Actions

Pamidronate disodium?has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.

Veterinary Drugs and Treatments

Pamidronate may be useful in treating hypercalcemia associated with vitamin D-related toxicoses or hypercalcemia of malignancy. There is ongoing research on the use of this drug to determine if it has clinical usefulness in directly treating “micro-metastases” in osteosarcomas.

Pamidronate disodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Pamidronate disodium salt Suppliers

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View Lastest Price from Pamidronate disodium salt manufacturers

Dideu Industries Group Limited
Product
Pamidronate disodium salt 57248-88-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-28
Zhuozhou Wenxi import and Export Co., Ltd
Product
Pamidronate disodium salt 57248-88-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Pamidronate disodium salt 57248-88-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

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  • CGP 23339AE
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  • Sodium (3-amino-1-hydroxypropane-1,1-diyl)bis(hydrogen phosphonate)
  • 57248-88-1
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  • C3H9NO7P22Na
  • C3H9NO7P2Na2
  • C3H11NO7P22Na
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  • BioChemical
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