Pamidronate disodium salt
- Product Name
- Pamidronate disodium salt
- CAS No.
- 57248-88-1
- Chemical Name
- Pamidronate disodium salt
- Synonyms
- cgp23339a;PAMIDRONATE;CGP 23339AE;PAMIDRONICDISODIUMSALT;PaMidronate DisodiuM API;Pamidronate disodium salt;Disodium Pamidronate Pamidronate (sodium salt);Disodium Pamidronate Hydrate;Pamidronate disodium hydrate
- CBNumber
- CB9707409
- Molecular Formula
- C3H12NNaO7P2
- Formula Weight
- 259.07
- MOL File
- 57248-88-1.mol
Pamidronate disodium salt Property
- Melting point:
- 300 °C
- storage temp.
- 2-8°C
- solubility
- H2O: 28 mg/mL
- form
- solid
- color
- white
- Merck
- 14,7003
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 57248-88-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-48-41-37/38-20/21/22
- Safety Statements
- 22-26-36/37/39-45
- RIDADR
- 3077
- WGK Germany
- 3
- RTECS
- SZ6525000
- HazardClass
- IRRITANT
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- P2371
- Product name
- Pamidronate disodium salt hydrate
- Purity
- ≥95% (NMR), solid
- Packaging
- 10mg
- Price
- $133
- Updated
- 2024/03/01
- Product number
- P2371
- Product name
- Pamidronate disodium salt hydrate
- Purity
- ≥95% (NMR), solid
- Packaging
- 100mg
- Price
- $616
- Updated
- 2024/03/01
- Product number
- BP615
- Product name
- Disodium pamidronate
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $259
- Updated
- 2023/06/20
- Product number
- D3921
- Product name
- Disodium Pamidronate Hydrate
- Purity
- >97.0%(T)
- Packaging
- 100mg
- Price
- $52
- Updated
- 2024/03/01
- Product number
- D3921
- Product name
- Disodium Pamidronate Hydrate
- Purity
- >97.0%(T)
- Packaging
- 1g
- Price
- $302
- Updated
- 2024/03/01
Pamidronate disodium salt Chemical Properties,Usage,Production
Description
Disodium pamidronate is a calcium metabolism regulator useful in the treatment of hypercalcemia associated with malignancy. It presumably reduces the bone resorption of calcium by inhibiting the formation and attachment of osteoclasts. Other potential uses include osteoporosis and calcitonin-resistant Paget’s disease.
Chemical Properties
White Crystals
Originator
Henkel (United Kingdom)
Uses
Pamidronate disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis. It is used to prevent bone loss, and treat osteoporosis.
Uses
A farnesyl diphosphate synthase inhibitor
Uses
A bisphosphonate antiresorptive agent; bone resorption inhibitor.
Manufacturing Process
For a batch size of 5 L, 587.5 g (3.2 moles) of mannitol is dissolved in 3.5 L of water. Pamidronic acid (31.6 g, 0.133 moles) is mixed with a 1.0 L aliquot of the mannitol solution to form a slurry. The slurry is then transferred into the remainder of the mannitol solution, and stirred for at least 15 min. Aqueous 1 N sodium hydroxide (270 ml) is then added and the mixture is stirred until a clear, colorless solution results. The pH is then adjusted to 6.50.1 using either 1 M aqueous phosphoric acid or 1 N aqueous sodium hydroxide, as needed. The solution is then filtered through a 0.22 micron filter, and filled at 20°C into vials at 4.0 ml (4.172 g)/vial, under sterile conditions. The aqueous solution is frozen at -37°C and lyophilized (20 mbar, 20°-40°C) to yield 1,250 vials, each containing 30 mg of amorphous disodium pamidronate. The vials are sealed under positive nitrogen pressure. The disodium pamidronate is amorphous (noncrystalline) by X-ray diffraction and contains 0.7 wt-% water.
brand name
Aredia (Novartis).
Therapeutic Function
Bone resorption suppressant
Biochem/physiol Actions
Pamidronate disodium?has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.
Veterinary Drugs and Treatments
Pamidronate may be useful in treating hypercalcemia associated with vitamin D-related toxicoses or hypercalcemia of malignancy. There is ongoing research on the use of this drug to determine if it has clinical usefulness in directly treating “micro-metastases” in osteosarcomas.
Pamidronate disodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pamidronate disodium salt manufacturers
- Product
- Pamidronate disodium salt 57248-88-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-28
- Product
- Pamidronate disodium salt 57248-88-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Pamidronate disodium salt 57248-88-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09