Doxifluridine
- Product Name
- Doxifluridine
- CAS No.
- 3094-09-5
- Chemical Name
- Doxifluridine
- Synonyms
- flutron;5'-DFUR;5'DFURD;furtulon;AMC 0101;5-F-5‘-dU;RO-21-9738;5-cl-5'-dU;Doxifluidine;DOXIFLURIDINE
- CBNumber
- CB4461786
- Molecular Formula
- C9H11FN2O5
- Formula Weight
- 246.19
- MOL File
- 3094-09-5.mol
Doxifluridine Property
- Melting point:
- 188-192 °C(lit.)
- alpha
- D25 +18.4° (c = 0.419 in water)
- Density
- 1.3751 (estimate)
- refractive index
- 20 ° (C=1, H2O)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 7.4(at 25℃)
- color
- White
- Merck
- 14,3437
- CAS DataBase Reference
- 3094-09-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-24/25
- WGK Germany
- 2
- RTECS
- YU7526000
- Hazard Note
- Irritant
- HazardClass
- IRRITANT, IRRITANT-HARMFUL
- HS Code
- 29349990
- Toxicity
- LD50 (14 day) in mice or rats (mg/kg): >1000 i.v.: >2000 s.c.; in male, female mice, male, female rats (mg/kg): >5000, >5000, 3471, 3390 orally (Shimizu)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F8791
- Product name
- 5-Fluoro-5′-deoxyuridine
- Packaging
- 25MG
- Price
- $86.6
- Updated
- 2023/06/20
- Product number
- Y0001644
- Product name
- Capecitabine impurity B
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- Y0001644
- Price
- $218
- Updated
- 2023/06/20
- Product number
- F8791
- Product name
- 5-Fluoro-5′-deoxyuridine
- Packaging
- 100MG
- Price
- $267
- Updated
- 2023/06/20
- Product number
- F8791
- Product name
- 5-Fluoro-5′-deoxyuridine
- Packaging
- 250MG
- Price
- $466
- Updated
- 2023/06/20
- Product number
- PHR2850
- Product name
- 5′-deoxy-5-fluorouridine
- Purity
- certified reference material, pharmaceutical secondary standard
- Packaging
- 50MG
- Price
- $452
- Updated
- 2022/05/15
Doxifluridine Chemical Properties,Usage,Production
Description
Doxifluridine is a prodrug derivative of 5-fluorouracil (5-FU). As an antineoplastic it is more potent than 5-FU in the treatment of breast, stomach, colon and rectal cancers.
Chemical Properties
White Solid
Originator
Hoffmann-LaRoche (USA)
Uses
A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity
Uses
An antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine
Uses
antineoplastic, pyrimidine antimetabolite
Uses
5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes.
Definition
ChEBI: A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluoro racil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase.
brand name
Furtulon
Biochem/physiol Actions
Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity.
Doxifluridine Preparation Products And Raw materials
Raw materials
Preparation Products
Doxifluridine Suppliers
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View Lastest Price from Doxifluridine manufacturers
- Product
- 5-Fluoro-5′-deoxyuridine 3094-09-5
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- ≥98.0%
- Supply Ability
- 10kg/month
- Release date
- 2021-09-28
- Product
- Doxifluridine 3094-09-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-05
- Product
- Doxifluridine 3094-09-5
- Price
- US $19.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100tons
- Release date
- 2021-12-06