ChemicalBook > CAS DataBase List > 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine

2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine

Product Name
2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine
CAS No.
161599-46-8
Chemical Name
2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine
Synonyms
DFCR;Capecitabine Impurity D;Capecitabine Impurity M;InterMediate of Capecitabine;uorocytidine;Capecitabine-2;-5'-deoxy-5-fL;2',3'-Di-O-acetyL;Capecitabine Imp.D;Capecitabine USP IMp.D
CBNumber
CB81090886
Molecular Formula
C13H16FN3O6
Formula Weight
329.28
MOL File
161599-46-8.mol
More
Less

2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine Property

Melting point:
196-198C
Boiling point:
427.4±55.0 °C(Predicted)
Density 
1.57±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
soluble in Methanol
form 
powder to crystal
pka
2.49±0.10(Predicted)
color 
White to Almost white
InChI
InChI=1S/C13H16FN3O6/c1-5-9(22-6(2)18)10(23-7(3)19)12(21-5)17-4-8(14)11(15)16-13(17)20/h4-5,9-10,12H,1-3H3,(H2,15,16,20)/t5-,9-,10-,12-/m1/s1
InChIKey
NWJBWNIUGNXJGO-YHHSPFQVSA-N
SMILES
C[C@H]1O[C@@H](N2C=C(F)C(N)=NC2=O)[C@H](OC(=O)C)[C@@H]1OC(=O)C
CAS DataBase Reference
161599-46-8(CAS DataBase Reference)
More
Less

Safety

Safety Statements 
24/25
HS Code 
29389090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
D4969
Product name
2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$56
Updated
2026/03/19
TCI Chemical
Product number
D4969
Product name
2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$168
Updated
2026/03/19
TCI Chemical
Product number
D4969
Product name
2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$447
Updated
2026/03/19
TRC
Product number
D322500
Product name
2’,3’-Di-O-acetyl-5’-deoxy-5-fluorocytidine
Packaging
10g
Price
$770
Updated
2021/12/16
AK Scientific
Product number
B773
Product name
2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine
Packaging
100g
Price
$850
Updated
2021/12/16
More
Less

2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

Capecitabine intermediate

Uses

A metabolite of Capecitabine. Capecitabine Diacetyl Amino Impurity (USP).

Definition

ChEBI: A member of the class of cytidines that is a metabolite of the drug capecitabine.

Synthesis

The synthesis of 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-D-cytidine requires two steps, as follows:
(1) Synthesis of 2',3'-Di-O-acetyl-5-fluorocytidine
Under nitrogen atmosphere, add 38.7 g of 2',3',5'-tri-O-acetyl-5-fluorocytidine to 200 mL of 2-methyl-2-oxobutanone. When the temperature is lowered to -5 to 0°C, add 29.5 g of (t-Bu)₂Sn(OH)Cl. Maintained at this temperature for 2 hours, then the solvent was removed under reduced pressure. The residue was filtered through silica gel (50 g, 300–400 mesh), eluted with chloroform, and the eluate concentrated to dryness under reduced pressure. A white solid (32.2 g) was obtained, yielding 93.3% with a purity of 98.6%.
(2) Synthesis of 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-D-cytidine
Under nitrogen atmosphere, add 32.2 g 2',3'-di-O-acetyl-5-fluorocytidine and 31.7 g trifluoroacetic acid to 200 mL chloroform. Maintain temperature at -10 to -5°C and add 14.1 g triethylsilane dropwise. After completion of addition, react at this temperature for 3 h. Upon completion of the reaction as indicated by TLC, the residue was washed twice with 300 ml purified water and once with 200 ml saturated sodium bicarbonate solution. After drying and evaporating to dryness, 80 g ethanol was added for recrystallisation. The mixture was cooled to 0–5°C, filtered under vacuum, and dried to yield 29.5 g of product. The yield was 96.1% with a purity of 99.7%.

2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine Suppliers

Americas 1 Canada 1 China 387 China Hong Kong 1 Europe 2 Germany 1 India 51 Japan 1 Russia 1 Spain 1 United Kingdom 3 United States 24 Global 474
Shanghai Dongyue Biochem Co.,Ltd.
Tel
13512134376
Email
rlzyb@dybiochem.com
Country
China
ProdList
33
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44802
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
13552068683 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
11780
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9254
Advantage
66
More
Less

View Lastest Price from 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.
Product
2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine 161599-46-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
20tons
Release date
2025-08-26
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine 161599-46-8
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
500kg
Release date
2021-10-29
Hebei Chuanghai Biotechnology Co., Ltd
Product
2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine 161599-46-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2025-03-12

161599-46-8, 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidineRelated Search:

Cytidine Chlorfluazuron Fluazinam Trifloxysulfuron FLONICAMID 5'-deoxy-5-fluore-N-[(pentoyloxy)carbonyl]cytidine 2',3'-diacetate 5'-Deoxy-5-fluorocytidine Capecitabine-2',3'-cyclic Carbonate Diosmin 1,2,3-Triacetyl-5-deoxy-D-ribose Capecitabine Acetyl coenzyme A sodium salt Acetyl chloride 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene 3'-O-(5'-Deoxy-α-D-ribofuranosyl) Capecitabine 2'-O-(5'-Deoxy-β-D-ribofuranosyl) Capecitabine CAPECITABINE related substance USP Doxifluridine

  • Capecitabine Impurity M
  • Capecitabine Impurity C (EP )
  • InterMediate of Capecitabine
  • (2R,3R,4R,5R)-2-(4-aMino-5-fluoro-2-oxopyriMidin-1(2H)-yl)-5-Methyltetrahydrofuran-3,4-diyl diacetate
  • 2',3'-di-O-acetyl-5'-deoxy-5-fulurocytidine
  • 2,3-diACETATE 5,DEOXY 5,FLUORO CYTIDINE
  • Cytidine,5'-deoxy-5-fluoro-, 2',3'-diacetate
  • Capecitabine USP IMp.D
  • Capecitabine Impurity 13(Capecitabine EP Impurity C)
  • Capecitabine EP Impurity C
  • Capecitabine-2
  • Capecitabine impurity 4/Capecitabine EP Impurity C/Capecitabine Diacetyl Amino Impurity (USP)/2’,3’-Di-O-acetyl-5’-deoxy-5-fluorocytidine
  • [(2R,3R,4R,5R)-4-acetoxy-5-(4-amino-5-fluoro-2-oxo-pyrimidin-1-yl)-2-methyl-tetrahydrofuran-3-yl] acetate
  • Capecitabine Diacetyl Amino Imp
  • 2',3'-Di-O-acetyl-5'-deoxy-5-F-Cytidine
  • 3'-di-O-acetyl-5'-deoxy-5-fulurocytidine
  • Capecitabin iMpurity D
  • Capecitabine Impurity M(Capecitabine EP Impurity C)
  • 2',3'-Di-O-carbonyl-5'-deoxy-5-fluorocytidine
  • 2 ', 3'-di-O-acetyl -5' - deoxy -5-- fluoro-D-cell pyridine
  • 5'-deoxy - diacetyl -5-- fluoro cytidine
  • 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-D-cytidine
  • 2,3-DI-O-ACETYL-5-DEOXY-5-FULURO-D-CYTIDINE
  • 2',3'-DI-O-ACETYL-5'-DEOXY-5-FLUOROCYTIDIN
  • Capecitabine Diacetyl Amino Impurity
  • 2',3'-Di-O-acetyl-5'-deoxy-5-fulurocytdine
  • 2',3'-Di-o-acetyl-5-fluoro cytidine
  • (2R,3R,4S,5R)-2-(4-Amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyltetrahydrofuran-3,4-diyl di
  • 5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine
  • (2R,3R,4S,5R)-4-(acetyloxy)-2-(4-aMino-5-fluoro-2-oxo-1,2-dihydropyriMidin-1-yl)-5-Methyloxolan-3-yl acetate
  • 2',3'-Diacetoxyl-5'-deoxy-5-flurocytidine
  • 5'-Deoxy-5-fluoro-cytidine 2',3'-Diacetate
  • Capecitabine Imp.D
  • 2',3'-Di-O-acetyL
  • uorocytidine
  • 2,3-Di-O-acetyl-5-deoxy-5-fluoro-D-cytidine [CAP5]
  • 2',3'-Di-O-acetyl-5'-deoxy-5-flouro-D-cytidine
  • -5'-deoxy-5-fL
  • 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine USP/EP/BP
  • DFCR
  • (2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-2-fluoro-5-methyltetrahydrofuran-3,4-diyl diacetate
  • Cytidine, 5'-deoxy-5-fluoro-, 2',3'-diacetate (9CI, ACI)
  • 5'-deoxy-5-fluoro-Cytidine 2',3'-diacetate (9CI ACI)
  • 2'',3''DiOacetyl5''deoxy5fuluroDcytidine,2'',3'' Di O acetyl 5'' deoxy 5 fuluro D cytidine
  • 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine
  • 5’-Deoxy-5-fluorocytidine 2’,3’-Diacetate
  • 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine
  • 2'',3''-Di-O-acetyl-5''-deoxy-5-fuluro-D-cytidine
  • Cytidine, 5'-deoxy-5-fluoro-, 2',3'-diacetate
  • 1-(2,3-Di-O-acetyl-5-deoxy-beta-D-ribofuranosyl)-4-amino-5-fluoropyrimidin-2(1H)-one
  • 2'''',3''''-Di-O-acetyl-5''''-deoxy-5-fuluro-D-cytidine
  • 2'''',3''''-Di-O-acetyl-5''''-deoxy-5-fuluro-D-cytidine, 10 mM in DMSO
  • 2',3'-DI-O-ACETYL-5'-DEOXY-5-FULUROD-CYTIDI
  • 5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine (Capecitabine Impurity)
  • 2,3-Di-O-acetyl-5-Deoxy-5-fluorocytidine - Capecitabine intermediates
  • Capecitabine Impurity D
  • 161599-46-8
  • 161500-46-8